Effect of polypeptide 2B1 on condition of dampness pattern in rats in terms of Traditional Chinese Medicine

Yang, Zhangbin; Xiang, Ting; Zhang, Shijun; Zhan, Hongrui; Chen, Zexiong; Sun, Baoguo; Chen, Xiaoling; Shi, Jingli; Ren, Bin

doi:10.1016/s0254-6272(14)60081-9

Cited by 6 publications

(4 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Firstly, one previously undescribed compound, butyl cinnamoyl(4-hydroxyphenethyl) Carbamate (1), and 21 known (2-22) compounds of Solanum verbascifolium L. were identified as N-benzoyl-L-phenylalanino (2), [10] N-(N-benzoyl-L-phenylalanyl)-L-phenylalanol (3), [11] 3-(4-hydroxyphenyl)-N-[ 2-(4-hydroxyphenyl)-2-meth-oxyethyl]-acrylamide (4), [12] N-p-coumaroyl tyramine (5), [13] N-trans-feruloyltyramine (6), [14] N-trans-pcoumaroyloctopamine (7), [15] N-cis-feruloyltyramine (8), [16] 9), [17] methyl pyroglutamate (10), [18] 4-hydroxycinnamic acid (11), [19] C-Veratroycol (12), [20] threo-7R,8R-7-O-ethylguaiacylglycerol (13), [21] 2-(4-hydroxy-3-methoxyphenyl)-3-(2hydroxy-5-methoxyphenyl)-3-oxo-1-propanol ( 14), [22] thero-2,3bis-(4-hydroxy-3-methoxypheyl)-3-methoxy-propano (15), [23] 3hydroxy-2-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)propan-1-one ( 16), [24] erythro-2,3-bis(4-hydroxy-3-methoxyphenyl)-3-ethoxypropan-l-ol (17), [25] 4-2-[3-(4-hydroxy-3-methoxyphenyl)-3-hydroxy-propan-1-ol]-O-pinoresinol ( 18), [26][27] threo-(7R,8R)-guaiacylglycerol 8-vanillin ether ( 19), [28] erythro-(7S,8R)guaiacylglycerol 8-vanillin ether (20), [28] Samwiphenol (21), [29] Ficusal ( 22), [30] respectively. The isolated structures were obtained through the implementation of diverse chromatographic techniques, including silica gel, ODS, and HPLC, along with an analysis of their physical properties.…”

Section: Resultsmentioning

confidence: 99%

Chemical Constituents from the Heartwood of Solanum Verbascifolium L. And Their Anti‐Inflammatory Activities Combined Network Pharmacology

Zhao,

Yu,

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

Phytochemical studies on 95% ethanol extract of the heartwood of Solanum verbascifolium L. resulted in the isolation of one new amide derivative (1), and 21 known phenylpropanoids compounds. The structures were characterized by spectral analysis and high‐resolution mass spectrometric analysis. The anti‐inflammatory activity of amide compounds 1‐4 and 6‐9 by investigating their impact on the release of nitric oxide (NO) in MH‐S cells. Our findings unveiled significant inhibitory effects on NO secretion. Compound 1 exhibited robust dose‐dependent suppression, with pronounced inhibition observed at both 20 μM (P < 0.01) and 40 μM (P < 0.01). Furthermore, compound 9 demonstrated noteworthy inhibitory effects at 40 μM (P < 0.01). Similarly, compounds 3 and 4 displayed substantial inhibition of NO secretion at the same concentration, although the significance level was slightly lower (P < 0.05). It is expected that there is a substantial association between the anti‐inflammatory activities of amides and their targets, specifically PTGS2, by combining network pharmacology and molecular docking techniques. This discovery emphasizes amides' potential as an interesting subject for additional study in the realm of anti‐inflammatory medications.

show abstract

Section: Resultsmentioning

confidence: 99%

Chemical Constituents from the Heartwood of Solanum Verbascifolium L. And Their Anti‐Inflammatory Activities Combined Network Pharmacology

Zhao,

Yu,

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

“…The word "vertigo" first appeared in the "Three Causes and One Disease Prescription", which said that "the prescription called the head and face wind, namely vertigo is also" [9], it refers to a kind of disease syndrome with dizziness as the main manifestation. Chinese medical scientists in the past dynasties have had quite rich discussions on the etiology and pathogenesis of vertigo, as well as the classification of syndromes, but in summary, there are nothing more than "virtual" and "real" [10].…”

Section: Understanding Of "Vertigo" In Traditional Chinese Medicinementioning

confidence: 99%

Research Progress of Chinese and Western Medicine in the Pathogenesis and Treatment of Vertigo

Liang¹,

Liu²,

Yang³

et al. 2023

HSET

View full text Add to dashboard Cite

In recent years, with the progress of society and the change of lifestyle, the incidence of vertigo is gradually increasing. However, the current understanding of the pathogenesis and treatment of vertigo is limited, which leads to poor clinical diagnosis and treatment effect. The author analyzed the pathogenesis and treatment methods of vertigo from the perspectives of Western medicine and traditional Chinese medicine respectively, and summarized the related factors of vertigo, the research progress of traditional Chinese and western medicine treatment methods of vertigo, and the latest application research status of new ideas and new ideas for vertigo treatment. Based on the incidence types of vertigo, the overall concept and dialectical thinking of traditional Chinese medicine are put forward to guide the clinical treatment. The objective is to explore the advantages and disadvantages of Western medicine and traditional Chinese medicine in the treatment of vertigo, and integrate their advantages and disadvantages, in order to provide the best treatment plan for more vertigo patients, so as to improve the quality of life of patients.

show abstract

“…the pharmacological activities include antidepressant effect, anti-inflammatory effect and hepatoprotective effect, antioxidant effect, etc. In our continuing investigation on chemical consitituents of Gentiana [5,6], six compounds were isolated from the ethanol extract of the whole plant, linoleic acid(1), dibutyl-phthalate(2), p-hydroxy benzaldehyde (3), hydroxyacetophenone (4), isoscoparin (5), 5,7,3',4'-tetrahydroxyflavone-6-β-D-glucopyranoside(6), the cytotoxic activity on the growth of HepG-2 cells of all compounds were investigated in MTT assay.…”

Section: Introductionmentioning

confidence: 96%

Chemical Constituents and Cytotoxic Activity of <i>Gentiana farreri Balf.f.</i>

Yang

Sun

et al. 2013

AMR

View full text Add to dashboard Cite

Six compounds were isolated from Gentiana farrerii, which was used as traditonal herb medicine in the treatment of some diseases. Their structures were identified as: linoleic acid(1), dibutyl-phthalate(2), p-hydroxy benzaldehyde (3), hydroxyacetophenone (4), isoscoparin (5), 5,7,3',4'-tetrahydroxyflavone-6--D-glucopyranoside(6). All compounds were isolated from Gentiana farrerii for the first time. The cytotoxic activity on the growth of HepG-2 cells of all compounds were investigated in MTT assay, the results showed that compound 2, 5, 6 have weak cytotoxic activity, IC50 is 41.26, 96.74, 99.33 (μg/ml), respectively.

show abstract

Effect of polypeptide 2B1 on condition of dampness pattern in rats in terms of Traditional Chinese Medicine

Cited by 6 publications

References 12 publications

Chemical Constituents from the Heartwood of Solanum Verbascifolium L. And Their Anti‐Inflammatory Activities Combined Network Pharmacology

Chemical Constituents from the Heartwood of Solanum Verbascifolium L. And Their Anti‐Inflammatory Activities Combined Network Pharmacology

Research Progress of Chinese and Western Medicine in the Pathogenesis and Treatment of Vertigo

Chemical Constituents and Cytotoxic Activity of <i>Gentiana farreri Balf.f.</i>

Contact Info

Product

Resources

About