Effect of Powdered Fermented Milk withLactobacillus helveticuson Subjects with High-Normal Blood Pressure or Mild Hypertension

Abstract

Daily ingestion of the tablets containing powdered fermented milk with L. helveticus CM4 in subjects with high-normal blood pressure or mild hypertension reduces elevated blood pressure without any adverse effects.

Fermented lactotripeptides-containing milk lowers daytime blood pressure in high normal-to-mild hypertensive subjects

“…It has been proposed that a reduction in blood pressure is larger with higher starting blood pressure levels. 1,7 This is supported by our observation that the reduction in SBP was larger in the subgroup of subjects with higher blood pressure at the start of the intervention.…”

“…Aihara et al 1 did not find an acute effect of LTP, but in that study blood pressure was measured only once at 2-3 h after intake. This might have been insufficient to detect an effect, because blood pressure is highly variable.…”

“…Several placebo-controlled studies show that ingestion of LTP-containing fermented products for several weeks can reduce systolic and diastolic blood pressure (SBP/DBP) in high normal-to-mild hypertensive subjects. [1][2][3][4][5][6][7][8][9] However, limited information about the acute effects of LTPs during the first hours after ingestion is available. Thus, it remains unknown whether intake at frequencies less than daily over weeks would have similar blood pressure-lowering effects.…”

“…[1][2][3] Other studies suggest that 2-4 weeks is not long enough and that at least 6-12 weeks of intervention are needed to elicit a longerterm LTP-induced effect. [4][5][6][7][8] The latter studies are more in line with our observation, as we did not observe a significant additional 4-week effect.…”

The antihypertensive effect of fermented milk in individuals with prehypertension or borderline hypertension

“…Reduced BP were observed in the intervention groups in most studies, with SBP reduction ranging from 12 mm Hg to none. [14][15][16][17][18][19][20] Methods and results are inconsistent and there is great heterogeneity between human studies, where the BP at inclusion varies from grade II hypertension to prehypertension. Prehypertensives are particularly relevant when studying the effect of lifestyle interventions, although it might be difficult to show significant BP reductions in this group.…”