Effect of Preoperative Rectal Indomethacin on Postoperative Pain Reduction After Open Cholecystectomy

Bahar, Mostafa Mehrabi; Jangjoo, Ali; Soltani, Ehsan; Armand, M; Mozaffari, Samira

doi:10.1016/j.jopan.2009.11.002

Cited by 3 publications

(3 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of the included trials, 89 did not mention SAEs, 28–116 and two trials mentioned potential SAEs without specifying in which intervention group these events occurred 117,118 . Lack of response to email inquiries meant these studies could not provide relevant or quantifiable data for any of our outcomes.…”

Section: Resultsmentioning

confidence: 99%

Risks of serious adverse events with non‐steroidal anti‐inflammatory drugs in gastrointestinal surgery: A systematic review with meta‐analysis and trial sequential analysis

Bukhari,

Leth,

Laursen

et al. 2024

Acta Anaesthesiol Scand

View full text Add to dashboard Cite

BackgroundNon‐steroidal anti‐inflammatory drugs (NSAIDs) are commonly recommended for perioperative opioid‐sparing multimodal analgesic treatments. Concerns regarding the potential for serious adverse events (SAEs) associated with perioperative NSAID treatment are especially relevant following gastrointestinal surgery. We assessed the risks of SAEs with perioperative NSAID treatment in patients undergoing gastrointestinal surgery.MethodsWe conducted a systematic review of randomised clinical trials assessing the harmful effects of NSAIDs versus placebo, usual care or no intervention in patients undergoing gastrointestinal surgery. The primary outcome was an incidence of SAEs. We systematically searched for eligible trials in five major databases up to January 2024. We performed risk of bias assessments to account for systematic errors, trial sequential analysis (TSA) to account for the risks of random errors, performed meta‐analyses using R and used the Grading of Recommendations Assessment, Development and Evaluation framework to describe the certainty of evidence.ResultsWe included 22 trials enrolling 1622 patients for our primary analyses. Most trials were at high risk of bias. Meta‐analyses (risk ratio 0.78; 95% confidence interval [CI] 0.51–1.19; I2 = 4%; p = .24; very low certainty of evidence) and TSA indicated a lack of information on the effects of NSAIDs compared to placebo on the risks of SAEs. Post‐hoc beta‐binomial regression sensitivity analyses including trials with zero events showed a reduction in SAEs with NSAIDs versus placebo (odds ratio 0.73; CI 0.54–0.99; p = .042).ConclusionIn adult patients undergoing gastrointestinal surgery, there was insufficient information to draw firm conclusions on the effects of NSAIDs on SAEs. The certainty of the evidence was very low.

show abstract

Section: Resultsmentioning

confidence: 99%

Risks of serious adverse events with non‐steroidal anti‐inflammatory drugs in gastrointestinal surgery: A systematic review with meta‐analysis and trial sequential analysis

Bukhari,

Leth,

Laursen

et al. 2024

Acta Anaesthesiol Scand

View full text Add to dashboard Cite

show abstract

“…To date, laparoscopy cholecystectomy (LC) is the approach of choice for acute cholecystitis and has replaced open cholecystectomy (OC) [10], because LC reduces postoperative morbidity and hospital stay. However, OC is the current treatment of care for others [11]- [16] and OC has been associated with severe postoperative pain [17] [18]. However, the intensity of pain due to cholecystectomy in diabetic patients to date remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Diabetic Patients Develop Greater Intensity of Postoperative Pain than Non-Diabetics after Open Cholecystectomy: A Pilot Study

Martínez-Alpuche¹,

Brindis-Fuentes²,

Guzmán-Priego³

et al. 2021

JBM

View full text Add to dashboard Cite

Background: Pre-clinical and clinical studies have shown that inflammatory pain intensity is increased under diabetes condition. Open cholecystectomy (OC) is a surgical procedure with predictable postoperative pain. However, the comparison of postoperative pain due to open cholecystectomy in diabetic and non-diabetic patients remains unknown. The research question to answer was whether diabetic patients undergoing OC development greater intensity of postoperative pain than non-diabetic patients. Methods: The study was conducted between June 2016 and February 2018 at the Regional Hospital of High Specialty "Dr. Juan Graham Casasús" of Villahermosa, Tabasco, Mexico. Seventy patients in two groups of 35 patients each scheduled for OC under general anesthesia were studied. Pain was assessed using the 11-point numerical rating scale (NRS). The primary endpoint was to know NRS pain scores after awaking of general anesthesia. Secondary outcomes included the time of onset of pain and comparing NRS scores between diabetic and non-diabetic patients undergoing OC. Results: Diabetic patients reported significantly greater intensity pain than non-diabetic patients. The mean overall pain score in the diabetic and non-diabetic patients was 7.2 ± 0.3 and 5.3 ± 0.3 (P = 0.0002), respectively. Furthermore, 60% of diabetic patients had severe pain (NRS ≥ 8) compared to 20% of non-diabetics (P = 0.006). The time to onset postoperative pain was about 35 minutes in both groups (P = 0.876). Conclusions: Diabetic patients undergoing OC have greater intensity postoperative pain and also more frequency of patients with severe pain

show abstract

“…[17][18][19][20] In this issue of the Journal of PeriAnesthesia Nursing, researchers from Iran present the findings of their excellent study on the use of preoperative rectal indomethacin in adults undergoing open cholecystectomy. 21 The researchers selected indomethacin primarily because it is widely available and inexpensive when compared with other nonopioid analgesics. They appropriately point out that indomethacin is associated with a higher risk of GI toxicity than some of the other nonopioids, and emphasize the need for appropriate patient selection criteria to prevent complications.…”

mentioning

confidence: 99%

Perioperative Rectal Administration of Nonopioid Analgesics

Pasero¹

2010

Journal of PeriAnesthesia Nursing

View full text Add to dashboard Cite

Effect of Preoperative Rectal Indomethacin on Postoperative Pain Reduction After Open Cholecystectomy

Cited by 3 publications

References 21 publications

Risks of serious adverse events with non‐steroidal anti‐inflammatory drugs in gastrointestinal surgery: A systematic review with meta‐analysis and trial sequential analysis

Risks of serious adverse events with non‐steroidal anti‐inflammatory drugs in gastrointestinal surgery: A systematic review with meta‐analysis and trial sequential analysis

Diabetic Patients Develop Greater Intensity of Postoperative Pain than Non-Diabetics after Open Cholecystectomy: A Pilot Study

Perioperative Rectal Administration of Nonopioid Analgesics

Contact Info

Product

Resources

About