Effect of preparation method on the properties of potato starch acetates with an equal degree of substitution

Zięba, Tomasz; Kapelko, M.; Szumny, Antoni

doi:10.1016/j.carbpol.2013.01.002

Cited by 44 publications

(25 citation statements)

References 21 publications

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“…NMR spectroscopy represents a simple and relatively low-cost analytical technique for obtaining unambiguous structural information, making it a basic tool in polymer analysis. We previously used NMR to successfully confirm the esterification of a series of natural polymers [30][31][32], as well as the structure of poly-NIPA microspheres [33].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, evaluation and release studies of NIPA nanopolymers presumed for temperature-controlled drug delivery

Gasztych

Valh

Kokol

et al. 2016

J Sol-Gel Sci Technol

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The copolymers of N-isopropyl acrylamide (NIPA) have been studied extensively as drug carriers for antibacterial, cardiovascular, cytostatic, local anesthetic, and nonsteroidal anti-inflammatory agents, to deliver the required therapeutic effect. The aim of this work was to evaluate the effect of a series of newly synthesized thermosensitive polymeric NIPA derivatives on the release rate of naproxen sodium (NS) from hydrogels composed of hydroxypropyl methylcellulose (HPMC). NIPA derivatives P1-P4 were synthesized by precipitation polymerization without an emulsifier, and their structures were evaluated by NMR spectroscopy. Four formulations were prepared with NS (FP1-FP4), and rate of NS release from these systems was evaluated using a modified pharmacopeial method at 22 and 42°C. The release rate of NS followed a similar trend in all four of the formulations assessed at 22°C, which was the same as the reference formulation. However, the release rate of NS at 42°C was clearly faster in the samples containing the thermosensitive polymers P1-P4 compared with the reference formulation. These results clearly demonstrate that the use of thermosensitive polymeric derivatives of NIPA can increase the release rate of NS from hydrophilic gels based on HPMC.Graphical Abstract Diversity of release courses of naproxen sodium evaluated in formulation containing poly(ethylene glycol) dimethacrylate (PDA, left), and comparison of half-release times (T HR , right) of naproxen sodium formulations containing various thermosensitive polymers P1-P4.

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Section: Introductionmentioning

confidence: 99%

Synthesis, evaluation and release studies of NIPA nanopolymers presumed for temperature-controlled drug delivery

Gasztych

Valh

Kokol

et al. 2016

J Sol-Gel Sci Technol

View full text Add to dashboard Cite

show abstract

“…The high amylolytic resistance of retrograded starch acetates has already been reported in our previous works (Kapelko et al, 2012a;Kapelko et al, 2012b;Zięba et al, 2011;Zięba et al, 2011a). The high resistance of such preparations to amylolysis results from high substitution of acetyl residues at the 2nd and 3rd carbon atom that are neighboring the hydrolyzed ␣-1,4 glycosidic bond (Zięba et al, 2013). A double chemical modification may contribute to the increasing resistance of the resultant preparations (Leszczyński, 2004).…”

Section: Type Of Preparationmentioning

confidence: 87%

“…Acetylated starch (E1420) and acetylated distarch adipate (E1422) produced under industrial conditions are characterized by increased viscosity of the formed pastes and hence are applied as thickening agents. Acetylated retrograded starch is also capable of forming viscous pastes (Kapelko et al, 2012b;Zięba et al, 2011;Zięba et al, 2013). The pasting characteristics resulting from its cross-linking caused that the R-ADA preparation was forming pastes with similar viscosity as that of native starch acetate (NS-A).…”

Section: Type Of Preparationmentioning

confidence: 98%

“…Determination of pasting characteristics with a Brabender viscograph (Zięba et al, 2013) Pasting characteristics was determined with a Brabender viscograph (Germany), using a measuring vessel (700 cmg type). Briefly, 450 mL of a suspension containing 6 g of starch per 100 g of solution were was prepared in the viscograph vessel.…”

Section: Determination Of the Content Of Adipate Groupsmentioning

confidence: 99%

“…potato); RS3 -retrograded starch (Englyst, Kingman, & Cummings, 1992), RS4 -chemically-or physically-modified starch (Haralampu, 2000); and RS3/RS4 -retrograded chemically-modified starch (Zięba, Szumny, & Kapelko, 2011a). The name of the last type of starch was proposed after investigations of acetylated starch produced from retrograded potato starch (Kapelko, Zięba, Golachowski, & Gryszkin, 2012a;Kapelko, Zięba, & Michalski, 2012b;Zięba, Kapelko, & Gryszkin, 2007;Zięba, Juszczak & Gryszkin, 2011;Zięba et al, 2011a;Zięba, Szumny, & Kapelko, 2011b;Zięba, Kapelko, & Szumny, 2013). This type of starch is characterized by significant resistance to the action of amylases (ca.…”

Section: Introductionmentioning

confidence: 96%

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