Effect of Priming Principle on Propofol Dose Required to Induce General Anesthesia

Hamid, Hafiz Muhammad; Masud, Sarmad; Waseem, Aamir; Bashir, Aamir; Samreen, Asma; Ashraf, Saima

doi:10.51985/jbumdc2019107

Cited by 1 publication

(1 citation statement)

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“…21 Hamid and his colleagues tried to use the priming principle to decrease the induction dose of propofol because propofol dose increment is directly related to cardiovascular depression. 22 The incidence of post-induction hypotension was also studied recently in 2022 and it was concluded that induction with propofol & thiopental and orthopedics surgery are the independent risk factors for this hypotension. 23 The most remarkable finding of our study was the higher values of standard deviations in each comparison.…”

Section: Discussionmentioning

confidence: 99%

Effects of body mass index on propofol-induced cardiovascular depression in the Pakistani population

Naeem

Waheed²,

Azeem³

et al. 2023

Pak J Med Sci

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Objective: To determine the relationship between the patient’s Body Mass Index (BMI) and the cardiovascular effects produced by propofol at a dose of 1.5 mg/kg in the Pakistani population. Methods: This descriptive cross-sectional study was conducted in the Holy Family Hospital Rawalpindi from August 2021 to January 2022. According to their BMI, one hundred twenty Pakistani individuals 18 to 60 years of age were equally divided into three groups. Group N (n = 40) with a BMI of 18 to 24.9, group OW (n=40) with a BMI of 25 to 29.5, and group O (n=40) with a BMI of 30 to 34.9 were randomized to receive propofol injections at a 1.5 mg/kg dose for induction of anesthesia. We measured mean blood pressure before the propofol and then at one, three, and ten minutes after the injection. Data were analyzed by using SPSS 22. Results: Mean blood pressure decreases significantly in all groups, as shown by p-values of <0.001 for the first two readings. In group N, blood pressure returned to near normal within ten minutes (p-value 0.061), but in groups, OW and O, mean blood pressure was significantly lower even after ten minutes (p-values 0.005 and 0.001, respectively). Individual variations in propofol response were also observed. Conclusion: In the Pakistani population, propofol at an induction dose of 1.5 mg/kg to patients with different body weights produces cardiovascular effects with marked standard deviations in each group, which indicate different individual responses. Clinical Trial Number: NCT05383534 https://register.clinicaltrials.gov/ doi: https://doi.org/10.12669/pjms.39.2.6787 How to cite this: Naeem U, Waheed A, Azeem Y, Awan MN. Effects of body mass index on propofol-induced cardiovascular depression in the Pakistani population. Pak J Med Sci. 2023;39(2):---------. doi: https://doi.org/10.12669/pjms.39.2.6787 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionmentioning

confidence: 99%