Effect of probiotic administration on the immune response: a systematic review of experimental models in rats

Abstract

The probiotic influence on the immune system, especially under pathogenic challenge conditions, still remains controversial. To address this, a systematic review of current studies concerning the efficacy of probiotics on the immune response of rats subjected to experimental challenges was conducted. The survey was conducted using PubMed, ISI Web of Science and Scielo databases. Only studies which tested probiotics in vivo in rats were included. The experimental design, methodological quality, and results of the articles were analyzed. In total 21 articles were selected for this study. The most commonly used microorganisms in the experiments were those of the genus Lactobacillus, which was reported in 12 articles. The second most often used genus was Bifidobacterium (B. animalis and B.longum). In general, the probiotics use against experimental pathogenic challenges was successful: 86% of the selected articles reported a beneficial effect on the immune response associated with the use of probiotics

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Use of probiotics in poultry to control Salmonella spp.: Review

“…As formas patogênicas de salmonelas não compõem esta microbiota que mantém o estado de higidez das aves domésticas (Salanitro et al, 1974). Com base nas características microbiológicas do lúmen intestinal, as culturas de probióticos são elaboradas com bactérias não patogênicas normalmente derivadas da microbiota normal que contribuem para exclusão de bactérias patogênicas no epitélio intestinal e para melhora significativa da resposta imune dos animais (Silva et al, 2012). O repovoamento do trato gastrintestinal com bactérias benéficas após eventos agressores da microbiota como enterites de origem bacteriana ou viral pode ser evitado pela inoculação contínua de cultivos probióticos que têm a capacidade de reduzir a ação bacteriana indesejável.…”