Recently, positive results have been achieved to reduce the risk of mycotoxicosis in meat poultry by rational use of various feed antioxidants, which inhibit processes of lipid peroxidation in the body and increase its immunity. The research aims to study the effect of different dosages of feed antioxidant Epofen on the basic economic and useful performance and digestive enzyme activity of broiler chickens grown on wheat-sorghumsunflower-based diets with tolerance level of T-2 toxin. To achieve this aim, the experiment using day-old "COBB-500" broiler chickens, which by the analogue scale were divided into 4 groups, was carried out on the poultry farm, agricultural production cooperative "Batraz", RNO-Alania. The resulting digital material was processed biometrically using the information program Excel. The research found that the best dose of feeding Epofen by reducing the risk of T-2 toxicosis in broilers is 200 g/t feed, which improves the basic economic and useful qualities and intensification of feed enzymolysis. At the same time versus counterparts from the control group, broilers in the second experimental group had increase in poultry stock safety by 4.0%, gross and daily average gainby 9.29% (P<0.05). Due to a better level of T-2 toxin detoxification by introducing preparation Epofen in mixed feed at a dose of 200 g/t feed, in the muscular stomach content of meat chickens of the second experimental group was significant (P<0.05) increase in protease activity by 11.61%, cellulaseby 19.93% and amylaseby 14.43%. Also, the broilers of the second experimental group showed a significant (P<0.05) increase in the activity of proteinases in the chyme of the small intestine by 15.50%. cellulaseby 14.19% and amylaseby 15.12%.