Effect of process variables on in vitro characteristics of clindamycin phosphate loaded PLGA nanoparticles in dental bone regeneration and 3D characterization studies using nano-CT

İlhan, Miray; Kiliçarslan, Müge; Orhan, Kaan

doi:10.1016/j.jddst.2022.103710

Cited by 5 publications

(11 citation statements)

References 39 publications

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“…Polymers can be fabricated in many different formulations, alone [ 120 , 121 , 122 ] or in conjunction with other polymers [ 119 , 123 , 124 ] or nanosystems [ 125 , 126 , 127 ] for their use as drug delivery systems in nanomedicine. The biocompatibility, lipophilicity, and gradual degradation properties of PLGA make it a suitable drug delivery system for sustained release purposes [ 113 , 128 , 129 ] and localized therapy [ 102 , 116 , 130 ]. PLGA can be formulated using different techniques to produce NPs [ 101 ], nanospheres [ 131 ], nanofibers [ 132 ], microspheres [ 133 ], and scaffolds [ 123 ].…”

Section: Techniques For Plga-based Nanostructure Preparationmentioning

confidence: 99%

“…PLGA can load/encapsulate both hydrophilic and lipophilic drugs using single [ 56 , 108 ] or double [ 116 , 131 ] emulsion methods. In single emulsions, the lipophilic active agent is mixed with PLGA in an organic phase, which is then added gradually to an aqueous phase while magnetic stirring to form an oil-in-water (O/W) emulsion.…”

Section: Techniques For Plga-based Nanostructure Preparationmentioning

confidence: 99%

“…The emulsion–solvent evaporation method may result in different particle types, such as NPs [ 110 , 111 ], microparticles [ 146 ], microspheres [ 120 , 133 ], and nanospheres [ 131 ]. PLGA molecular weight as well as its concentration, aqueous phase pH, stabilizer type and its concentration, homogenizer type, and speed are all important parameters in optimizing particle size, polydispersity index (PDI), particle surface charge (zeta potential), and encapsulation efficiency [ 116 , 145 , 147 , 148 ].…”

Section: Techniques For Plga-based Nanostructure Preparationmentioning

confidence: 99%

“…The preparation of PLGA polymers as nano-/microparticles makes them suitable for intravascular and intramuscular injections [ 121 , 130 ]. Due to their hydrophobicity, PLGA particles are used as drug delivery systems to prolong the half-lives of the loaded drugs and control their release [ 116 , 138 ]. As with other nanosystems, PLGA NPs’ surfaces may be functionalized with bone tissue-targeting molecules such as poly-aspartic acid sequences [ 166 ], zoledronate [ 139 ], tetracycline [ 167 ], or alendronate [ 168 ].…”

Section: Fabrication Forms Of Plga Particlesmentioning

confidence: 99%

“…Since bone scaffolds are implanted into the bone-defected area, bacterial inflammation signs may appear. Ilhan et al have prepared PLGA NPs for local delivery of clindamycin for alveolar bone regeneration, which have sustained release for up to 3 months upon a single injection [ 116 ].…”

Section: Plga-loaded Bioactive Molecules For Bone Regenerationmentioning

confidence: 99%

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Harnessing the Potential of PLGA Nanoparticles for Enhanced Bone Regeneration

Hassan,

Abdelnabi,

Mohsin

2024

Pharmaceutics

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Recently, nanotechnologies have become increasingly prominent in the field of bone tissue engineering (BTE), offering substantial potential to advance the field forward. These advancements manifest in two primary ways: the localized application of nanoengineered materials to enhance bone regeneration and their use as nanovehicles for delivering bioactive compounds. Despite significant progress in the development of bone substitutes over the past few decades, it is worth noting that the quest to identify the optimal biomaterial for bone regeneration remains a subject of intense debate. Ever since its initial discovery, poly(lactic-co-glycolic acid) (PLGA) has found widespread use in BTE due to its favorable biocompatibility and customizable biodegradability. This review provides an overview of contemporary advancements in the development of bone regeneration materials using PLGA polymers. The review covers some of the properties of PLGA, with a special focus on modifications of these properties towards bone regeneration. Furthermore, we delve into the techniques for synthesizing PLGA nanoparticles (NPs), the diverse forms in which these NPs can be fabricated, and the bioactive molecules that exhibit therapeutic potential for promoting bone regeneration. Additionally, we addressed some of the current concerns regarding the safety of PLGA NPs and PLGA-based products available on the market. Finally, we briefly discussed some of the current challenges and proposed some strategies to functionally enhance the fabrication of PLGA NPs towards BTE. We envisage that the utilization of PLGA NP holds significant potential as a potent tool in advancing therapies for intractable bone diseases.

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Section: Techniques For Plga-based Nanostructure Preparationmentioning

confidence: 99%

Section: Techniques For Plga-based Nanostructure Preparationmentioning

confidence: 99%

Section: Techniques For Plga-based Nanostructure Preparationmentioning

confidence: 99%

Section: Fabrication Forms Of Plga Particlesmentioning

confidence: 99%

Section: Plga-loaded Bioactive Molecules For Bone Regenerationmentioning

confidence: 99%

See 3 more Smart Citations

Harnessing the Potential of PLGA Nanoparticles for Enhanced Bone Regeneration

Hassan,

Abdelnabi,

Mohsin

2024

Pharmaceutics

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Clindamycin phosphate and bone morphogenetic protein-7 loaded combined nanoparticle-graft and nanoparticle-film formulations for alveolar bone regeneration – An in vitro and in vivo evaluation

İlhan

Kiliçarslan

Alçığır

et al. 2023

International Journal of Pharmaceutics

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Harnessing the Potential of PLGA Nanoparticles for Enhanced Bone Regeneration

Hassan,

Abdelnabi,

Mohsin

2023

Preprint

View full text Add to dashboard Cite

Recently, nanotechnologies have become increasingly prominent in the field of bone tissue engineering (BTE), offering substantial potential to advance the field forward. These advancements manifest in two primary ways: the localized application of nanoengineered materials to enhance bone regeneration and their use as nano-vehicles for delivering bioactive compounds. Despite significant progress in the development of bone substitutes over the past few decades, it is worth noting that the quest to identify the optimal biomaterial for bone regeneration remains a subject of intense debate. Ever since its initial discovery, poly(lactic-co-glycolic acid) (PLGA) has found widespread use in BTE due to its favorable biocompatibility and customizable biodegradability. This review provides an overview of contemporary advancements in the development of bone regeneration materials using PLGA polymer. The review covers some of PLGA properties with a special focus on modifications of these properties towards bone regeneration. Furthermore, we delve into the techniques for synthesizing PLGA nanoparticles (NPs), the diverse forms in which these NPs can be fabricated, and the bioactive molecules that exhibit therapeutic potential for promoting bone regeneration. Additionally, we addressed some of the current concerns regarding the safety of PLGA NPs, and PLGA-based products available in the market. Finally, we briefly discussed some of the current challenges and proposed some strategies to functionally enhance the fabrication of PLGA NPs towards BTE. We envisage that the utilization of PLGA NP holds significant potential as a potent tool in advancing therapies for intractable bone diseases.

show abstract

Effect of process variables on in vitro characteristics of clindamycin phosphate loaded PLGA nanoparticles in dental bone regeneration and 3D characterization studies using nano-CT

Cited by 5 publications

References 39 publications

Harnessing the Potential of PLGA Nanoparticles for Enhanced Bone Regeneration

Harnessing the Potential of PLGA Nanoparticles for Enhanced Bone Regeneration

Clindamycin phosphate and bone morphogenetic protein-7 loaded combined nanoparticle-graft and nanoparticle-film formulations for alveolar bone regeneration – An in vitro and in vivo evaluation

Harnessing the Potential of PLGA Nanoparticles for Enhanced Bone Regeneration

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