Effect of Processing Conditions and Material Attributes on the Design Space of Lysozyme Pellets Prepared by Extrusion/Spheronization

Effect of Processing Conditions and Material Attributes on the Design Space of Lysozyme Pellets Prepared by Extrusion/Spheronization

“…This study aimed to investigate the impact of the material attributes and processing parameters on the quality of the prepared pellets containing a macromolecular drug. Spraydried and lyophilized lysozymes were used as a model protein, crystalline and spray-dried mannitol were involved as conformation stabilizers [2] and microcrystalline cellulose served as pellet former. The experiments were conducted according to 2 3 full factorial design.…”