Effect of Prophylactic Low Level Laser Therapy on Oral Mucositis: A Systematic Review and Meta-Analysis

Oberoi, Sapna; Zamperlini–Netto, Gabriele; Beyene, Joseph; Treister, Nathaniel S.; Sung, Lillian

doi:10.1371/journal.pone.0107418

Cited by 160 publications

(105 citation statements)

References 48 publications

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“…LLLT in the supportive care of breast cancer patients Different clinical trials investigated the use of LLLT for a variety of side effects related to breast cancer treatment, such as breast cancer-related lymphedema (BCRL), oral mucositis (OM), radiodermatitis (RD), chemotherapy-induced peripheral neuropathy (CIPN), and osteonecrosis of the jaw (ONJ) [24][25][26].…”

Section: Lllt-mechanism Of Action On Cellular and Tissular Levelmentioning

confidence: 99%

The use of low-level light therapy in supportive care for patients with breast cancer: review of the literature

et al. 2016

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Breast cancer is the most common cancer in women worldwide, with an incidence of 1.7 million in 2012. Breast cancer and its treatments can bring along serious side effects such as fatigue, skin toxicity, lymphedema, pain, nausea, etc. These can substantially affect the patients' quality of life. Therefore, supportive care for breast cancer patients is an essential mainstay in the treatment. Low-level light therapy (LLLT) also named photobiomodulation therapy (PBMT) has proven its efficiency in general medicine for already more than 40 years. It is a noninvasive treatment option used to stimulate wound healing and reduce inflammation, edema, and pain. LLLT is used in different medical settings ranging from dermatology, physiotherapy, and neurology to dentistry. Since the last twenty years, LLLT is becoming a new treatment modality in supportive care for breast cancer. For this review, all existing literature concerning the use of LLLT for breast cancer was used to provide evidence in the following domains: oral mucositis (OM), radiodermatitis (RD), lymphedema, chemotherapy-induced peripheral neuropathy (CIPN), and osteonecrosis of the jaw (ONJ). The findings of this review suggest that LLLT is a promising option for the management of breast cancer treatment-related side effects. However, it still remains important to define appropriate treatment and irradiation parameters for each condition in order to ensure the effectiveness of LLLT.

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Section: Lllt-mechanism Of Action On Cellular and Tissular Levelmentioning

confidence: 99%

The use of low-level light therapy in supportive care for patients with breast cancer: review of the literature

et al. 2016

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“…In case of irradiation of tumours of the head and neck this complication is the most intensified in 4-6 weeks after treatment and usually lasts for a few weeks after radiotherapy [24].…”

Section: Streszczeniementioning

confidence: 99%

Procedure in the prevention and nurturing of inflammatory changes of oral mucositis among patients treated for oncological conditions

Kamińska¹,

Juszkiewicz²,

Tymicka³

et al. 2016

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Słowa kluczowe: zapalenie błony śluzowej jamy ustnej, chemioterapia, higiena jamy ustnej. AbstractOral mucositis is a serious complication occurring in the process of chemotherapy and/or radiotherapy. Ailments related to oral mucositis may bring about pain, reduce the amount of food intake, and eventually deteriorate the quality of life. This complication arises after radiotherapy, chemotherapy, transplantation of haematopoietic stem cells, and after molecularly targeted therapy. These symptoms may be the result of delay of treatment or dose reduction of successive cycles of chemotherapy, which, consequently, may have an impact on oncological treatment. StreszczenieZapalenie błon śluzowych jamy ustnej jest poważnym powikłaniem towarzyszącym chemioterapii i/lub radioterapii. Dolegliwości związane z przebiegiem zapalenia błon śluzowych jamy ustnej mogą powodować ból, ograniczać spożywanie pokarmów i ostatecznie pogarszać jakość życia chorych. Powikłanie to występuje po zastosowaniu radioterapii, chemioterapii, przeszczepieniu macierzystych komórek krwiotwórczych oraz leczeniu ukierunkowanym molekularnie. Objawy te mogą być przyczyną opóźnienia leczenia lub redukcji dawek kolejnych cykli chemioterapii, co w konsekwencji może rzutować na wyniki leczenia onkologicznego. Niezwykle istotne jest opracowanie zasad oceny stanu jamy ustnej i postępowania profilaktyczno-leczniczego, w tym instruktażu utrzymania higieny w jamie ustnej. Dokładne monitorowanie przebiegu całego leczenia i ukierunkowana edukacja może znacznie ograniczyć występowanie objawów niepożądanych.

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“…Thus, it was concluded that prophylactic LLLT helped in reducing severe mucositis and pain in patients with cancer and HSCT recipients. [17] It is recommended to have a 780-830 (nm) (infrared) Wavelength for analgesia with output between 10 and 100 (mW) which could be fixed or variable depending on the equipment and dose of 0.08-2 (J). [18] …”

Section: Mucositis Painmentioning

confidence: 99%

Role of low-level laser therapy in treatment of orofacial pain: A systematic review

Motwani¹,

Balpande²,

Pajnigara³

et al. 2016

JCRI

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Lasers have gained an upper hand in almost every field of dentistry. Utilization of lowlevel laser therapy (LLLT) which uses a power of <500 mW have matured over time. Its advantages surpass its pitfalls and hardly have any contraindications. Low lasers interact photo-chemically leading to a change in the biochemical and molecular processes that normally occur in tissues such as healing or repair without the thermal effects, a process called bio-stimulation. It has been implied that low power lasers affects cellular metabolic processes and promotes beneficial biological effects such as analgesic, anti-inflammatory, and healing. Research suggests an analgesic effect, through the central release of serotonin and acetylcholine, and peripheral release of histamine and prostaglandins, with the use of LLLT. LLLT improve endorphin release and thereby impede nociceptive signals and control pain mediators. This article aims to review the interesting clinical applications of LLLT in different orofacial pain conditions in details so that we can help patients to live a pain-free life.

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Effect of Prophylactic Low Level Laser Therapy on Oral Mucositis: A Systematic Review and Meta-Analysis

Cited by 160 publications

References 48 publications

The use of low-level light therapy in supportive care for patients with breast cancer: review of the literature

The use of low-level light therapy in supportive care for patients with breast cancer: review of the literature

Procedure in the prevention and nurturing of inflammatory changes of oral mucositis among patients treated for oncological conditions

Role of low-level laser therapy in treatment of orofacial pain: A systematic review

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