Effect of Raw Soybean Meal and Amino Acids on Pancreatic Hypertrophy in Rats

Booth, A. N.; Robbins, D. J.; Ribelin, Wm. E.; DeEds, Floyd

doi:10.3181/00379727-104-25950

Cited by 130 publications

(46 citation statements)

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“…The ingestion of significant amount of trypsin inhibitors, disrupt the digestive process and may lead to undesirable physiological reactions [54]. In our result, we found high trypsin inhibitor activity in fruit (4.6 TIU/mg proteins) compared to leaf (3.5 TIU/mg proteins) ( Table 1).…”

Section: Antinutritional Factors (Anfs)supporting

confidence: 65%

Proximate composition, antioxidant activities and phenolic composition of <em>Cucumis sativus</em> forma hardwickii (Royle) W. J. de Wilde & Duyfjes

Attar¹,

Ghane²

2017

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A b s t r a c tIn the present investigation, nutritional, anti sativus of addition, appreciable amount of Vitamin C and E were also observed. Considerable antinutritional factors in leaf a methods. In sequential solvent extraction, methanol found to be the best in extraction of antioxidants which was supported with the highest antioxidant activities. Among all it was noted that leaves extracted with methanol had higher amount of phenols and flavonoids than fruit. In addition, the potent radical scavengers mainly phenolics were detected using RP HPLC where tannic acid, gallic acid and hydroxybenzoic acid were also fruit. Superior antioxidant potential may be due to presence of other bioactive compounds present in fruit. Additional research on bioactive properties of this plant is needed to explore this neglected wild cucumber for nutraceutica Keywords chromatography Introduction Nutrition is the basic need to ensure better health and development. Nutrient deficiency and/or over sufficiency cause various disorders such as diabetes, obesity, cardiovascular diseases, cancer [1]. The various epidemiological studies have been proved that balanced diet along with fruit and vegetables may reduce risk of many chronic diseases [2]. In order to meet optimum nutritional requirement, there is urgent need to explore wild plant species as a novel source of food. Across the world various geo communities uses series of wild plant species to meet their daily requirement of dietary energy. These wild resources are the best source of nutrient and bioactive compounds. In addition, it is also an important source of income to hunters, gatherers and rural people [3]. Exploring these wild plants as a source of functional foods assist us to alleviate malnutrition, hunger and illness within society. Such wild plants with high nutritional and low antinutritional potential are the prerequisite while deciding the functional foods. In the present investigation, nutritional, anti-nutritional and antioxidant potential of sativus forma hardwickii was evaluated for the first time. The results revealed that leaf and fruit of Cucumis sativus f. hardwickii were rich source of ash, carbohydrate, fat, fibre and proteins. In addition, appreciable amount of Vitamin C and E were also observed. Considerable antinutritional factors in leaf and fruit were noted which can be reduced by different processing methods. In sequential solvent extraction, methanol found to be the best in extraction of antioxidants which was supported with the highest antioxidant activities. Among all t was noted that leaves extracted with methanol had higher amount of phenols and flavonoids than fruit. In addition, the potent radical scavengers mainly phenolics were detected using RP HPLC where tannic acid, gallic acid and hydroxybenzoic acid were also fruit. Superior antioxidant potential may be due to presence of other bioactive compounds present in fruit. Additional research on bioactive properties of this plant is needed to explore this neglected wild cucumber for nutraceutical...

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Section: Antinutritional Factors (Anfs)supporting

confidence: 65%

Proximate composition, antioxidant activities and phenolic composition of <em>Cucumis sativus</em> forma hardwickii (Royle) W. J. de Wilde & Duyfjes

Attar¹,

Ghane²

2017

ijpm

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“…Table 1 gives the organ and body weight after the three treatments as compared with controls. Body weight was markedly decreased in the soybean-fed animals due to the deficiency in amino acids in this meal (BOOTH et al, 1960). In other treatments no changes in body weight were noticed as compared with control values.…”

Section: Weight Measurementsmentioning

confidence: 81%

“…Enlargement of the pancreas in rats fed soybeans or trypsin inhibitor or repeatedly injected with CCK-PZ has been widely known and confirmed in the present study, but the cytological basis of this change has been studied only poorly. BOOTH et al (1960) briefly mentioned occasional mitotic figures in the exocrine pancreas of rats fed for 36 days with raw soybeans. ROTHMAN and WELLS (1967), on the other hand, demonstrated the increased weight of the pancreas in rats repeatedly given CCK-PZ and suggested that hypertrophy of individual acinar cells due to increased synthesis of enzymes and other proteins in them might have caused this organ enlargement.…”

Section: Changes In Endocrine Pancreasmentioning

confidence: 99%

Hypertrophy and Hyperplasia in the Endocrine and Exocrine Pancreas of Rats Fed Soybean Trypsin Inhibitor or Repeatedly Injected with Pancreozymin

Yanatori

Fujita

1976

Arch. Histol. Jap., Arch. Histol. Jpn

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Summary.Rats were 1) fed raw soybeans for 30 days, 2) given trypsin inhibitor as drinking water for 7 days, or 3) repeatedly injected with cholecystokinin-pancreozymin (CCK-PZ) for 7 days. After all these treatments the pancreas of the animals was markedly enlarged.Microscopic examination revealed, besides hypertrophy of acinar cells, increased mitotic figures in the acinar, centro-acinar, intercalated portion and excretory duct cells. The islets of Langerhans were found conspicuously enlarged due to mitotic proliferation of B cells. The endogenous CCK-PZ released by the intraluminal trypsin inhibitor and the exogenous CCK-PZ given by injections thus exerts not only secretagogous, but also trophic effects upon the endocrine and exocrine pancreas.The exocrine pancreas likely is affected also by the increased release of insulin from the B cells stimulated by CCK-PZ.

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“…However, Fitzgerald and co-workers have elegantly demonstrated pancreatic regeneration after cessation of ethionine administration or surgical resection of half the gland (7)(8)(9). MIoreover, pancreatic hypertrophy anid hyperplasia have been described in chickens and rats fed raw or uncooked soybeans (10)(11)(12) (19) and used by us previously.…”

Section: Introductionmentioning

confidence: 99%

Hormonal Control of Pancreatic Growth

Mainz¹,

Black²,

Webster³

1973

J. Clin. Invest.

239

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A B S T R A C T Investigations have outlined pancreatic secretory and synthetic responses to gastrointestinal hormones. However, there is little information concerning hormonal influences on pancreatic growth.These studies were designed to examine effects of chronic administration of bethanechol and cholecystokinin-pancreozymin (CCK-PZ) on the pancreas. M\Iale albino rats were given saline, bethanechol, 6 mg/kg, or CCK-PZ, 20 U/kg, intraperitoneally twice daily and killed after 5 days. DNA was determined by the diphenylamine method using calf thymus DNA as a standard (20). RNA was determined by the orcinol method using ribose as a standard (21). Protein was determined by the biuret method using bovine serum albumin as the standard (22). Radioactivity was assayed in a Packard liquid scintillation counter (Packard Instrument Co., Inc., Downers Grove, Ill.) using a phosphor developed by Patterson and Greene (23). Fig. 1 shows rates of incorporation of ["C]thymidine into pancreatic DNA. Under these conditions of in vitro incubation, incorporation was near linear for 30, 60, 90, 120, and 150 min. Other investigators, using different tissues, have shown that thymidine nucleotide pools were small and that there was rapid equilibration between intracellular and extracellular thymidine pools (24). In addition, at concentrations of ["C]thymidine used in these experiments, no labeled ["C]thymidine triphosphate remained unincorporated in the cell (25). These observations were considered sufficient to validate the use of in vitro incubation of pancreas for short-term studies of DNA synthesis. A 90 min period of in vitro incubation was used for other experiments. RESULTS

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Effect of Raw Soybean Meal and Amino Acids on Pancreatic Hypertrophy in Rats

Cited by 130 publications

References 0 publications

Proximate composition, antioxidant activities and phenolic composition of <em>Cucumis sativus</em> forma hardwickii (Royle) W. J. de Wilde & Duyfjes

Proximate composition, antioxidant activities and phenolic composition of <em>Cucumis sativus</em> forma hardwickii (Royle) W. J. de Wilde & Duyfjes

Hypertrophy and Hyperplasia in the Endocrine and Exocrine Pancreas of Rats Fed Soybean Trypsin Inhibitor or Repeatedly Injected with Pancreozymin

Hormonal Control of Pancreatic Growth

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Effect of Raw Soybean Meal and Amino Acids on Pancreatic Hypertrophy in Rats

Cited by 130 publications

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Proximate composition, antioxidant activities and phenolic composition of <em>Cucumis sativus</em> forma hardwickii (Royle) W. J. de Wilde &amp; Duyfjes

Proximate composition, antioxidant activities and phenolic composition of <em>Cucumis sativus</em> forma hardwickii (Royle) W. J. de Wilde &amp; Duyfjes

Hypertrophy and Hyperplasia in the Endocrine and Exocrine Pancreas of Rats Fed Soybean Trypsin Inhibitor or Repeatedly Injected with Pancreozymin

Hormonal Control of Pancreatic Growth

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Product

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Proximate composition, antioxidant activities and phenolic composition of <em>Cucumis sativus</em> forma hardwickii (Royle) W. J. de Wilde & Duyfjes

Proximate composition, antioxidant activities and phenolic composition of <em>Cucumis sativus</em> forma hardwickii (Royle) W. J. de Wilde & Duyfjes