Effect of Recombinant Human Bone Morphogenetic Protein 2 Associated With a Variety of Bone Substitutes on Vertical Guided Bone Regeneration in Rabbit Calvarium

Abstract

The use of rhBMP-2/absorbable collagen sponge (ACS) combined with all of the bone substitute materials tested resulted in a greater amount of bone formation than that produced with the bone substitute materials alone or rhBMP-2/(ACS) and CL using the rabbit calvarium GBR model.

Effects of BMP-2 Delivery in Calcium Phosphate Bone Graft Materials with Different Compositions on Bone Regeneration

“…In the present study, CPP with Ca/P ratio of 1 was compared with BCP with Ca/P ratio of 1.55, the most common graft material in clinical practice. In recent years, numerous studies have incorporated growth factors, such as, rhBMP-2, with various bone graft biomaterials to enhance bone regeneration [24]. The bone regeneration capacity of rhBMP-2 is dependent on carrier type [36,37], and a good carrier should load protein easily, secure a space for regeneration, and exhibit bioabsorbable and bioactive degradation.…”

“…The use of synthetic bone in clinical practice is limited by lack of osteoinductivity [24]. Osteoinductive proteins, such as recombinant human bone morphogenetic protein-2 (rhBMP-2), promote the differentiation of mesenchymal stem cells (MSCs) and pre-osteoblast into osteoblasts and trigger the migration of osteoblasts [25,26].…”

“…Some studies have confirmed rhBMP-2 has a favorable effect on new bone formation when used in conjunction with BCP or HA for the rehabilitation of alveolar defects [24,31]. However, no study has yet investigated the rhBMP-2/CPP combination even though CPP degrades faster than β -TCP or HA and has a porous architecture that could be used to deliver rhBMP-2 [18].…”

In Vitro Evaluation of Demineralized Freeze‐Dried Bone Allograft in Combination With Enamel Matrix Derivative

“…The goal of regenerative periodontal surgery is to predictably restore the tooth's supporting apparatus (i.e., root cementum, periodontal ligament [PDL], and bone), which have been lost following periodontal disease or trauma 1‐3 . Various bone grafts, including autogenous bone, allografts, xenografts, and synthetic alloplasts, have been used with varying degrees of success for the treatment of bone and periodontal defects 4‐12 . One grafting material that has been particularly effective because of its combination of osteoconduction and osteo‐induction is demineralized freeze‐dried bone allograft (DFDBA) 13‐17 .…”

Effects of Recombinant Human Bone Morphogenetic Protein‐2 on Vertical Bone Augmentation in a Canine Model

“…In animal models or clinical trials, BMPs were applied in combination with various carrier systems for the purpose of bone regeneration in the procedures of socket grafting, 16 , 19 sinus grafting, 20 , 21 periodontal repair, 22 localized bone augmentation, 17 , 23 and implant osseointegration 16 , 24 . Previous literature has shown that recombinant human bone morphogenetic protein (rhBMP)‐2 could not only promote osseointegration, but also induce new bone formation in VBA 25 , 26 …”