Effect of recombinant Lactococcus lactis producing myelin peptides on neuroimmunological changes in rats with experimental allergic encephalomyelitis

Abstract

A b s t r a c t

Contribution of plasmid-encoded peptidase S8 (PrtP) to adhesion and transit in the gut of Lactococcus lactis IBB477 strain

“…It serves as a starter culture for the production of a variety of cheeses, as well as other dairy products such as sour cream and buttermilk. Owing to the long history of safe consumption and the availability of molecular tools, lactococci have a great potential as mucosal delivery vehicles for therapeutic and prophylactic molecules (Bermudez-Humaran et al 2011 ; Hugentobler et al 2012 ; del Carmen et al 2013 ; Szatraj et al 2014 ; Kasarełło et al 2016 ). The ability of L. lactis to adhere to the intestinal mucosa can potentially prolong the contact with the host, and therefore favour its persistence in the gut.…”

The engineered probiotics for the treatment of chronic diseases: A systematic review

“…But, there are some advantages in applying EPs compared to pure therapeutic proteins. Regarding inevitable hydrolysis of therapeutic proteins after oral administration, the reported results have been dose-dependent (Kasarełło et al, 2015(Kasarełło et al, , 2016. On the other hand, the purification of proteins is the most expensive step in the production of recombinant proteins.…”

“…These findings indicated that OT induction is not related to the host viability. Kasarełło et al (2015, 2016) manipulated LL to express secretory forms of MOG35‐55, MBP85‐97, and PLP139‐151. The authors revealed that oral gavage of the EP lysate improves clinical signs of EAE only in high dose; while, treatment with low dosages had no significant effects on EAE features.…”

“…These findings indicated that OT induction is not related to the host viability. Kasarełło et al (2015Kasarełło et al ( , 2016 et al, 2015). After release from EPs, there is a low probability of GLP-1 absorption.…”

Bioactive peptides produced by engineered probiotics and other food-grade bacteria: A review

“…jensenii 1153–1666 Reduction in transmission of a chimeric simian/HIV 3 after repeated vaginal tests in macaques Lagenaur et al, 2011 Dendritic cell-targeting peptide fused with PEDV 4 core neutralizing epitope antigen Lb. casei ATCC 393 Antiviral probiotic vaccine against PEDV 4 in pigs Wang et al, 2017 Anti-inflammatory Pentadecapeptide BPC-157 L. lactis NZ9000 Decrease ROS 5 concentration in fibroblast cells as possible treatment against IBD 6 and GIT 7 inflammations Škrlec et al, 2018 EDG 8 , TFF 9 L. lactis PSM565 Repair of mucosal epithelial barriers, accelerate cells migration Huynh & Li, 2015 Cathelicidin L. lactis NZ3900 Reduction of inflammation in mice with colitis Zhang et al, 2016b , Wong et al, 2017 α-melanocyte-stimulating hormone B. longum HB15 Anti-inflammatory effect during ulcerative colitis induction in rats Wei et al, 2016 Anticancer Kisspeptin L. lactis NZ9000 Inhibition of HT-29 proliferation and migration, mediating apoptosis, down-regulation MMP-9 10 expression Zhang et al, 2016a TFF 11 L. lactis (sAGX0085) Reduction of days with ulcerative oral mucositis in locally advanced head and neck cancer patients Limaye et al, 2013 Immune stimulation Myelin peptide fragments L. lactis IBB360 Decrease of histopathological changes, reduction of serum IL-1b, IL-10 and TNF-α Kasarello et al, 2016 Gliadin L. lactis MG1363 Suppression of local and systemic gluten-sensitive disorders in non-obese diabetic mice Huibregtse et al, 2009 1 ...…”