Effect of red ginger extract (Zingiber officinale var. Rubrum) of SGOT and SGPT levels in white rats (Rattus norvegicus) induced by Gentamicine

Abstract

Introduction: The aim of the research was to prove that red ginger extract (Zingiber officinale var. Rubrum) could inhibit the increase in SGOT and SGPT levels in Gentamicin-induced rats. Objective: Twenty-five male rats aged 8-12 weeks with 150-200 gram BW divided into five groups research with C- was given CMC-Na 1% and aqua pro-injection, C+ was given 1% CMC-Na and induction of Gentamicin 80 mg/kg BW, and groups T1, T2, and T3 given induction of Gentamicin 80 mg/kg BW and red ginger extract at individual doses each of 100, 200, and 400 mg/kg BW. All treatments were carried out for 15 days. On the 16th day, all rats were euthanized and their blood was drawn intracardiacly, then SGOT and SGPT levels were examined. The results of the research used the Analysis of Variance (ANOVA) and Games-Howell statistical analysis. Results: The results showed that the C+ group experienced the highest increase (p<0.05) while the C-group experienced the lowest increase (p<0.05) compared to the other treatment groups. The T1, T2, T3 groups were able to inhibit the increase in SGOT and SGPT levels. Conclusion: The effective dose to inhibit the increase in SGOT levels is 400 mg/kg BW and the effective dose to inhibit the increase in SGPT levels is 200 mg/kg BW.