Effect of Roxithromycin on the Activity of Enzyme ERND in the Kidney of Mollusk (<i>Cipangopaludina</i><i> chinensis</i>)

Abstract

Cipangopaludina chinensis which is a species of benthic macroinvertebrates was exposed to roxithromycin, and tested the erythromycin N-demethylase (ERND) of kidney, then explored the effect of roxithromycin on the biochemical indicator of C.chinensis. The results showed that roxithromycin had effect on the activity of ERND in the kidney of C.chinensis and the overall trend was promoting at the beginning then suppressing at the end, but the differences of the influence caused by different concentrations of roxithromycin was not obvious. In addition, it appeared from the survival condition of control group and experimental group, roxithromycin which is a kind of antibiotic, had no lethal effect on C.chinensis. But the concentration of roxithromycin which is more than 250 times, 500 times and 750 times of the environment used in this experiment had significant influence on the enzyme activity of the ERND in the kidney of C.chinensis.