Effect of Running Training on DMH-Induced Aberrant Crypt Foci in Rat Colon

Fuku, Noriyuki; Ochiai, Masako; Terada, Shin; Fujimoto, Eri; Nakagama, Hitoshi; Tabata, Izumi

doi:10.1249/01.mss.0000239398.78331.96

Cited by 24 publications

(15 citation statements)

References 31 publications

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“…The mostly used carcinogen for inducing colon cancer in the animal model is azoxymethane (AOM), the metabolite of dimethylhydrazine (DMH) but more toxic than DMH. It was found that the injection of 20 mg/kg wt of DMH for 5 weeks resulted in 28–30 ACFs [18, 19]. The injection of AOM in similar dosages produced much more severe symptoms, in which more than 200 ACFs were induced [20, 21].…”

Section: Discussionmentioning

confidence: 99%

Soy Saponins Meditate the Progression of Colon Cancer in Rats by Inhibiting the Activity ofβ-Glucuronidase and the Number of Aberrant Crypt Foci but Not Cyclooxygenase-2 Activity

et al. 2013

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Objective. The effect of extracted crude soybean saponins on preneoplastic lesions, aberrant crypt foci (ACF), and the related mechanism were investigated. Research Methods and Procedures. Rats were assigned into five groups according to different doses of extracted crude soybean saponins and received 1,2-dimethylhydrazine (DMH) injection in week 5. In week 15, all rats were sacrificed. The number of ACFs, the cyclooxygenase-2 (COX-2) protein expression, the level of prostaglandins E2 (PGE2), and the activity of β-glucuronidase were examined. Results. Results revealed that the consumption of extracted crude soybean saponins decreased the number of ACFs and the activity of β-glucuronidase in rats, while the expression of COX-2 protein and PGE2 level were not affected. Conclusions. Soybean saponins were effective in inhibiting colon cancer by downregulating the activity of β-glucuronidase in colonic mucosa but not the COX-2 protein expression and PGE2 level.

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Section: Discussionmentioning

confidence: 99%

Soy Saponins Meditate the Progression of Colon Cancer in Rats by Inhibiting the Activity ofβ-Glucuronidase and the Number of Aberrant Crypt Foci but Not Cyclooxygenase-2 Activity

et al. 2013

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“…Additionally, epidemiologic evidence indicates a negative correlation between exercise amount and subsequent risk of developing colorectal cancer (5,24,34,42). In experimental studies, a treadmill running exercise reduced the number of 1,2-dimethylhydrazine-induced aberrant crypt foci, a biomarker for colorectal carcinogenesis, in rats (14). In Apc min mice, voluntary (20) and treadmill (4) running exercise inhibited intestinal tumorigenesis.…”

Section: Discussionmentioning

confidence: 99%

Voluntary wheel running exercise and dietary lactose concomitantly reduce proportion of secondary bile acids in rat feces

Hagio

Matsumoto

Yajima

et al. 2010

Journal of Applied Physiology

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According to epidemiologic studies, a negative correlation exists between exercise amount and subsequent cancer development risk in the large intestine. The proportion of secondary bile acids (SBA) in the large intestine is related to subsequent risk for colorectal carcinogenesis. The aim of this study was to investigate the effects of voluntary wheel running exercise and dietary intervention on bile acid (BA) metabolism in the large intestine. Wistar/ST rats (6 wk old) were divided into two groups, exercise and sedentary, after acclimation. Four days after the animals were assigned to a group, rats in each group were fed diets supplemented with different carbohydrate sources including dextrin, sucrose, and lactose. The wheel running period was 4 wk in the exercise group, whereas rats in the sedentary group remained in individual cages during this period. BA composition in collected feces was analyzed with ultraperformance liquid chromatography-electrospray ionization mass spectrometry. We found that wheel running exercise decreased plasma concentrations of cholesterol, triglyceride, and free fatty acids. These decreases were accompanied by a reduction in the proportion of SBA to primary BA (PBA) in feces; however, daily excretion of BA was comparable regardless of wheel running exercise. In addition, ingestion of lactose decreased the SBA-to-PBA ratio and suppressed production of hyodeoxycholic acid in feces. In conclusion, voluntary wheel running exercise, in combination with dietary intervention, could independently reduce the SBA-to-PBA ratio within the large intestine without changing BA excretion. These changes may contribute to the prevention of colorectal carcinogenesis.

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“…However, a mild aerobic training counteracted the effects of carcinogen exposure, reducing proliferation and inflammation in the colon (3). Aerobic training has also been shown to reduce not only preneoplastic lesion, but also tumor formation in the colon (4,5). Our results, together with those of previous studies (3-5, 17, 32), highlight that physical exercise has different effects depending on its modality and the tissue analyzed, as well as on carcinogen exposure.…”

Section: Discussionsupporting

confidence: 79%

Efeitos do exercício físico associado à luz contínua na carcinogênese colônica em ratos

Frajacomo¹

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Effect of Running Training on DMH-Induced Aberrant Crypt Foci in Rat Colon

Abstract: The results of the present investigation suggest that low-intensity running training inhibits the DMH-induced initiation of colon ACF development.

Cited by 24 publications

References 31 publications

Soy Saponins Meditate the Progression of Colon Cancer in Rats by Inhibiting the Activity ofβ-Glucuronidase and the Number of Aberrant Crypt Foci but Not Cyclooxygenase-2 Activity

Soy Saponins Meditate the Progression of Colon Cancer in Rats by Inhibiting the Activity ofβ-Glucuronidase and the Number of Aberrant Crypt Foci but Not Cyclooxygenase-2 Activity

Voluntary wheel running exercise and dietary lactose concomitantly reduce proportion of secondary bile acids in rat feces

Efeitos do exercício físico associado à luz contínua na carcinogênese colônica em ratos

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