Effect of S-Adenosyl-L-Methionine (SAMe) upon depressive symptoms

Agnoli, A.; Andreoli, V. M.; Casacchia, M; Cerbo, R.

doi:10.1016/0022-3956(76)90008-x

Cited by 106 publications

(35 citation statements)

References 3 publications

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“…9 SAM is required for several transmethylation reactions involving polyamines, proteins and phospholipids. [10][11][12][13] SAM also plays a role in cell proliferation and regulation. 14 SAM is used as a prescription drug for arthritis, depression, and liver disease in Europe, and is taken as a nutritional supplement in the USA.…”

mentioning

confidence: 99%

S‐adenosyl L‐methionine inhibits azoxymethane‐induced colonic aberrant crypt foci in F344 rats and suppresses human colon cancer Caco‐2 cell growth in 3D culture

Guruswamy

Swamy

Choi

et al. 2007

Intl Journal of Cancer

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S-Adenosyl L-methionine (SAM) is a universal methyl group donor to various intermediary metabolites, hormones, proteins, neurotransmitters, phospholipids and nucleic acids. Deficiency of folate, which plays a role in the synthesis of SAM leads to increased risk for colon cancer. This study tested the effectiveness of SAM supplementation in protecting against azoxymethane (AOM)-induced colon carcinogenesis in male F344 rats. We also tested the effect of SAM on cyclooxygenase-2 (COX-2) in a macrophage cell line. Further, we developed a 3-D culture model using Caco-2 cells to test the effect of SAM on tumor spheroid size and number. Groups of rats were given the experimental diet containing either 0-, 400-or 800-ppm SAM, 1 week before the first AOM injection and continued until 8 weeks. In the control group, AOM produced a substantial number of aberrant crypt foci (ACF) (96 6 8). Dietary administration of SAM significantly reduced the number of total ACF (400 ppm SAM, 68 6 7.3, p < 0.01 and 800 ppm SAM, 57 6 7.1, p < 0.001). SAM significantly decreased AOM-induced colonic multicrypt foci in a dose-dependent manner. Suppression of Lipopolysaccharide (LPS) induced COX-2 protein expression was observed in a RAW264.7 cell line. We established growth of Caco-2 cells as spheroids, in a 3D matrix of collagen and matrigel. Treatment with SAM decreased both size and number of spheroids in a dose-dependent manner (p < 0.0001). These observations demonstrate for the first time that SAM can reduce the occurrence of ACF in AOM treated male F344 rats and suppress formation of human tumor spheroids and expression of COX-2. ' 2007 Wiley-Liss, Inc.

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mentioning

confidence: 99%

S‐adenosyl L‐methionine inhibits azoxymethane‐induced colonic aberrant crypt foci in F344 rats and suppresses human colon cancer Caco‐2 cell growth in 3D culture

Guruswamy

Swamy

Choi

et al. 2007

Intl Journal of Cancer

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“…Depression has for some time now been known to be associated with deficiencies in neurotransmitters such as serotonin, dopamine, noradrenaline, and GABA [22][23][24][25][26][27]. As reported in several studies, the amino acids tryptophan, tyrosine, phenylalanine, and methionine are often helpful in treating many mood disorders, including depression [28][29][30][31][32][33]. Tryptophan is a precursor to serotonin and is usually converted to serotonin when taken alone on an empty stomach.…”

Section: Major Depressionmentioning

confidence: 99%

Nutritional Therapies for Mental Disorders

Lakhan¹,

Vieira²

2013

Functional Foods

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“…SAM also serves to methylate N-acetyl-serotonin, via indoleamine methyltransferase to form melatonin and in the process may deplete serotonin (5-HT). These are major metabolic processes since DA, NE and 5-HT are important in synaptic transmission and in behavior (Agnoli et al, 1976) and are reported to be depleted in PD. So, SAM is a highly reactive endogenous molecule.…”

Section: S-adenosyl-l-methionine (Sam): a Model Precipitating Factor mentioning

confidence: 99%

Fetal and Environmental Basis for the Cause of Parkinson’s Disease

Charlton¹

2013

Basal Ganglia - An Integrative View

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Effect of S-Adenosyl-L-Methionine (SAMe) upon depressive symptoms

Cited by 106 publications

References 3 publications

S‐adenosyl L‐methionine inhibits azoxymethane‐induced colonic aberrant crypt foci in F344 rats and suppresses human colon cancer Caco‐2 cell growth in 3D culture

S‐adenosyl L‐methionine inhibits azoxymethane‐induced colonic aberrant crypt foci in F344 rats and suppresses human colon cancer Caco‐2 cell growth in 3D culture

Nutritional Therapies for Mental Disorders

Fetal and Environmental Basis for the Cause of Parkinson’s Disease

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