Effect of selective and non-selective β-blockers on body weight, insulin resistance and leptin concentration in chronic heart failure

Abstract

This study found different metabolic effects of carvedilol and bisoprolol in non-cachectic patients with CHF. With unchanged fasting plasma glucose concentration after 6 months of treatment, carvedilol significantly decreased plasma insulin concentration and insulin resistance compared to bisoprolol.

The burden of chronic obstructive pulmonary disease in patients hospitalized with heart failure

“…Apart from well established mechanisms such as reduction of sympathetic drive and prevention of arrhythmia [17], other mechanisms should be mentioned [18]. Among other beneficial properties, beta-blockers improve the metabolic profile in terms of insulin sensitivity [19] and substrate utilization [20]. A considerable proportion of patients could have developed cachexia, an irreversible condition with grim outcome [9].…”

Insulin resistance and heart failure

“…The majority of β-blockers increase insulin resistance, although carvedilol, a combined α-and β-blocker, favorably infl uences myocardial metabolism by reducing FFA uptake [38]. A recent study reported that these benefi cial effects of carvedilol were not seen with bisoprolol, but the study investigated a relatively small number of patients, and further studies are required [39].…”

Combination antihypertensive therapy in patients with arterial hypertension and coronary heart disease

“…Высокая клиническая эффективность небиво-лола при различных сердечно-сосудистых заболе-ваниях -АГ, ИБС, в том числе у больных с СД на сегодняшний день имеет большую доказатель-ную базу -более 70 исследований [30][31][32][33][34][35].…”