Effect of Selenium on the Levels of Cytokines and Trace Elements in Toxin-Mediated Oxidative Stress in Male Rats

Ansar, Sabah

doi:10.1007/s12011-015-0403-7

Cited by 28 publications

(10 citation statements)

References 50 publications

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“…It has been shown that selenium plays an important role in the continuation of the physiological functions of the nervous system (such as signal transduction and development) (10). Previous studies have shown that selenium has a neuroprotective role in various experimental pathologies, such as spinal cord injury, cerebral ischemia and neurotoxicity models (11)(12)(13)(14)(15). Similarly, in our previous study, selenium prevented neurotoxicity that was induced by cisplatin in a partial level (16).…”

Section: Introductionsupporting

confidence: 72%

Effects of Selenium on Axon and Myelin Healing in an Experimental Sciatic Nerve Injury Model

Kızılay¹,

Erken²,

Aktaş³

et al. 2017

İstanbul Tıp Fakültesi Dergisi

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Objective: Although, the neuroprotective effects of selenium are known, its effect on peripheral nerve injury is not clear. The study was aimed to investigate whether selenium prevents axonal and myelin damage in experimental sciatic nerve injury. Materials and Methods: Twenty-eight male Wistar albino rats were divided into four groups (n=7 in each): control (C), selenium (S), injury (I), and selenium-treated injury (SI). Injury was generated by 30 second of compression via Yasargil aneurysm clip on the sciatic nerve of rats in the I and SI groups. Then, selenium was given to the S and SI groups as 1.5 mg/ kg by oral gavage at 1 st , 24 th , 48 th and 72 nd hour after surgery. According to the experimental protocol, electrophysiological, histological, and biochemical tests were performed end of the day 4. Results: Whereas the amplitude of compound action potential, nerve conduction velocity, average axon diameter, myelin thickness, myelinated/unmyelinated axons and SOD activity in red blood cells of the I group were significantly lower than those of the C, S and SI groups, the serum MDA levels of the I group were significantly higher than those of the C, S and SI groups. Conclusion:The findings of this study show that selenium decreases axonal and myelin damage after sciatic nerve injury and that this neuroprotective effect of selenium is at least partially mediated by oxidant/antioxidant mechanisms.

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Section: Introductionsupporting

confidence: 72%

Effects of Selenium on Axon and Myelin Healing in an Experimental Sciatic Nerve Injury Model

Kızılay¹,

Erken²,

Aktaş³

et al. 2017

İstanbul Tıp Fakültesi Dergisi

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“…Pb can also decrease the level of GSH by inhibiting the activities of GSH metabolizing enzymes, such as GR, GST, and glucose-6-phosphate dehydrogenase, by blocking their SH groups [19]. Our earlier studies have shown protective effect of natural polyphenols and antioxidants on toxin mediated toxicity in vivo [20][21][22]. Extensive research is now focusing on herbal products as alternative medicines and a number of studies showed the beneficial effects of curcumin [23] which undergoes metabolism upon oral administration in animals and almost each and every metabolite produced has some beneficial effect apart from their antioxidant property.…”

Section: Discussionmentioning

confidence: 99%

Effect of curcumin and curcumin nanoparticles against lead induced nephrotoxicity.

Ansar¹,

Farhat²,

Albati³

et al. 2019

biomedicalresearch

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The aim of the present study was to examine the protective effect of curcumin (CUR) and curcumin nanoparticles (CURNPs) as antioxidants on the nephrotoxicity induced by lead (Pb). CUR (60 mg/kg b.w) and CURNPs (30 mg/kg b.w) were evaluated using Pb (30 mg/kg b.w.) induced oxidative renal damage in rats. Administration of Pb significantly (p<0.001) increased the levels of renal function test such as creatinine (CRN) and blood urea nitrogen (BUN) and uric acid (UA). Furthermore, Pb significantly decreased glutathione (GSH) levels, superoxide dismutase (SOD), glutathione reductase (GR), catalase (CAT) and glutathione peroxidase (GPx) activities (p<0.001). CUR and CURNPs displayed a renal protective effect as evident by significant decrease in CRN, BUN, UA levels and elevated the antioxidant status of renal tissues. The administration of Pb also induced histopathological changes in renal tissue; however, in groups treated by CUR and CURNPs, there was amelioration in pathological changes in renal tissue. These findings suggest that Nano CUR could be a potential compound in combating the oxidative damage of renal tissue as it increases curcumin bioavailability.

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“…MDA levels are a marker of cellular lipid peroxidation, which indirectly reflects the degree of cell damage [32]. In addition, Ansar et al [33] showed that Se has a protective effect against oxidase activity. In accordance with Toxins 2020, 12, 143 9 of 14 this, we observed that the activity of GSH-Px, T-SOD and T-AOC in the liver of chickens exposed OTA were lower than those in the control group, while MDA levels were higher.…”

Section: Discussionmentioning

confidence: 99%

Selenium Yeast Alleviates Ochratoxin A-Induced Hepatotoxicity via Modulation of the PI3K/AKT and Nrf2/Keap1 Signaling Pathways in Chickens

Kang

Chao

Cui

et al. 2020

Toxins

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The aim of this study was to investigate the protective effects of selenium yeast (Se-Y) against hepatotoxicity induced by ochratoxin A (OTA). The OTA-induced liver injury model was established in chickens by daily oral gavage of 50 µg/kg OTA for 21 days. Serum biochemistry analysis, antioxidant analysis, as well as the qRT-PCR and Western blot (WB) analyses were then used to evaluate oxidative damage and apoptosis in chicken liver tissue. The results showed that Se-Y significantly increased liver coefficient induced by OTA (P < 0.05). OTA + Se-Y treated group revealed that Se-Y reduced the OTA-induced increase in glutamic pyruvic transaminase (ALT), glutamic oxaloacetic transaminase (AST) and malonaldehyde (MDA) content, and reversed the decrease in antioxidant capacity (T-AOC), glutathione peroxidase (GSH-Px) and total superoxide dismutase (T-SOD) (P < 0.05). In this study, we found that OTA is involved in the mRNA expression levels about Nrf2/Keap1 and PI3K/AKT signaling pathways, such as oxidative stress-related genes (Nrf2, GSH-Px, GLRX2 and Keap1) and apoptosis-related genes (Bax, Caspase3, P53, AKT, PI3K and Bcl-2). Besides, significant downregulations of protein expression of HO-1, MnSOD, Nrf2 and Bcl-2, as well as a significant upregulation of Caspase3 and Bax levels were observed after contaminated with OTA (P < 0.05). Notably, OTA-induced apoptosis and oxidative damage in the liver of chickens were reverted back to normal level in the OTA + Se-Y group. Our findings indicate that pretreatment with Se-Y effectively ameliorates OTA-induced hepatotoxicity.

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Effect of Selenium on the Levels of Cytokines and Trace Elements in Toxin-Mediated Oxidative Stress in Male Rats

Cited by 28 publications

References 50 publications

Effects of Selenium on Axon and Myelin Healing in an Experimental Sciatic Nerve Injury Model

Effects of Selenium on Axon and Myelin Healing in an Experimental Sciatic Nerve Injury Model

Effect of curcumin and curcumin nanoparticles against lead induced nephrotoxicity.

Selenium Yeast Alleviates Ochratoxin A-Induced Hepatotoxicity via Modulation of the PI3K/AKT and Nrf2/Keap1 Signaling Pathways in Chickens

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