Effect of Sesame Oil on Serum and Liver Lipid Profile in Hyperlipidemic Rats.

Abstract

This study was conducted to investigate the effect of sesame oil on serum and hepatic lipid profile in induced hyperlipidemic rat .Eight forty rats were randomly divided into equal six groups of eight animals each for 30 days as follows : The first group(control) was kept on basal diet and water, the second group was kept on basal diet added to it sesame oil (SSO)5%, the third group was given a basal diet supplemented by SSO10%,the fourth group (hyperlipidemic) ,hyperlipidemia was induced at last two weeks by intra peritoneal injection of Triton WR1339(200mg/Kg, /three times /week) ,fifth group was fed basal diet +i.p of Triton 200mg/Kg +SSO5%,the six group was kept on basal diet +i.p injection of same dose of Triton +SSO10%. Blood samples were collected and serum was separated for determination of the followings triglycerides, cholesterol, HDL(high density lipioprotin), LDL(low density lipoprotein),VLDL (very low density lipoprotein), ALT(Alanin aminotrancferase),AST(Aspartate aminotransferase),GGT (gamma glutamyl tranferase), ALP (Alkaline phosphatase) ,hepatic lipid profile , thyroid hormones and adiponectin hormone. Induction of hyperlipidema resulted in a significant elevation of all parameters except HDL, adiponectin and thyroid hormones not significant decrease compared to control group .supplementation with sesame oil 5% and SSO 10 % signaficantly decrease in all serum and hepatic lipid profile and liver enzymes while HDL ,adiponectin ,thyroid hormones are elevated. Conclusion: SSO 5% was possess a better improving potential for hyperlipidemia, serum glucose, adiponectin , thyroid hormones, hepatic lipid profile than SSO10% .

Potential Effects of Sage powder, Sesame and Olive Oils on Lipid Profile and Liver Functions of Non-Alcoholic Fatty Liver Rats.

“…Concerning the effects of (SO) on TL, TC and TG, our results are at the same line with (Taha et al, 2014) who reported that, treatment of hyperlipidimic rats with (SO) 5&10% showed hypolipidimic activity as they decreased hepatic level of TG & TC. Concerning sage effects on plasma lipids (Eidi and Eidi., 2009) reported that, sage ethanolic extract significantly decreased serum glucose, triglycerides and total cholesterol.…”

Effect of Sage, Sesame and Olive Oils Alone and in Combination with Sage on Weight Reduction and Fasting Blood Sugar in Obese Non-Alcoholic Fatty Liver Albino Rats.

“…Our results are at a harmony with (Taha et al, 2014)who reported that supplementation with (SO) possess a better improving potential for hyperlipidemia, serum glucose, adiponectin, thyroid hormones, hepatic lipid profile. Concerning sage effect on blood glucose level (Eidi et al, 2005)suggested that aqueous extract of sage has been found to exhibit insulinlike activities.…”

Effect of Halawa Tahinia Alone or with Ginger and Cinnamon on Sex Hormones in Adult Male Rats

“…Moreover, there were no significant changes were observed among the treated groups. So that ginger or cinnamon with Halawa tahinia have no side effects on liver functions Sesame oil at 5% was possess a better improving potential for hyperlipidemia, serum glucose, thyroid hormones and hepatic lipid profile than sesame oil at 10% [85].…”