Effect of sinapic acid on memory deficits and neuronal degeneration induced by intracerebroventricular administration of streptozotocin in rats

Shahmohamady, Pouneh; Eidi, Akram; Mortazavi, Pejman; Panahi, Negar; Minai-Tehrani, Dariush

doi:10.5114/pjp.2018.79546

Cited by 25 publications

(15 citation statements)

References 65 publications

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“…7 SP is effectively proven to prevent memory loss, counterbalancing oxidative stress and beneficial in the treatment of Alzheimer's disease. 8 So the present study was undertaken to evaluate effect of SY and SP in diabetic neuropathy.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Some Phenolic Acids in Diabetic Neuropathy

Pawar¹,

Upaganlawar²,

Upasani³

2021

IJPER

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Background: Streptozotocin (STZ) induced neuropathy is widely used preclinical model for diabetic neuropathy (DN). DN is majorly resulted due to nitrosative and oxidative stress induced by hyperglycemia. Phenolic acids are polyphenols with free radical scavenging anti-inflammatory and neuroprotectiveaction. Methods: In this study STZ (55mg/kg, i.p) was administered in male Wistar rats and animals with hyperglycemia (fasting blood glucose ≥ 200mg/dl) were used for further study. Behavioural changes cold allodynia, mechanical hyperalgesia, heat hyperalgesia, mechanical allodynia were assessed weekly. Motor Nerve Conduction Velocity (MNCV) was also evaluated. Reduced Glutathione and Malondialdehyde were estimated to indicate oxidative stress. C-Reactive Protein (CRP), Insulin assay, serum electrolytes (Na + , K +), TNF-α, IL-6 and INF-γ were also estimated. Isolated sciatic nerve was histopathologically studied to support the results. Results: Treatment with syringic acid (SY) 12.5, 25, 50 mg/kg and of Sinapic acid (SP) 5, 10, 20 mg/kg orally for 5 weeks has shown to reduce blood glucose level. Behavioural changes were found to be improved weekly by SY and SP in dose dependent manner. 5 weeks treatment with SY and SP was able to increase antioxidant GSH and reduce MDA level in cell. Gabapentin, SY and SP treated animals have shown decrease in TNF-α, IL-6 and INF-γ and CRP. Insulin and serum electrolytes were found to be normalised in treated groups. Histopathological study has revealed protective effect of gabapentin, SY and SP by showing reverted neuronal damage. Conclusion: In conclusion, syringic acid and sinapic acid have antihyperglycemic, antioxidant and neuroprotective effect in diabetic neuropathy.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Some Phenolic Acids in Diabetic Neuropathy

Pawar¹,

Upaganlawar²,

Upasani³

2021

IJPER

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“…Extensively found in spices, citrus, berry fruits, and vegetables ( Chen, 2016 ), SA is also known to exhibit antioxidant, anti-inflammatory, anticancer, and neuroprotective activities ( Chen, 2016 ; Zych et al, 2019 ). Both TSG and SA show protective effects on learning/memory deficits and cognitive impairment in AD animal models ( Lee et al, 2012 ; Sheng et al, 2016 ; Shahmohamady et al, 2018 ). However, to our knowledge, there is no report on the anti-Aβ42 aggregation effects of TSG and SA.…”

Section: Discussionmentioning

confidence: 99%

A Systematic Screening of Traditional Chinese Medicine Identifies Two Novel Inhibitors Against the Cytotoxic Aggregation of Amyloid Beta

Zheng

Chen

et al. 2021

Front. Pharmacol.

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The toxic aggregates of amyloid beta (Aβ) disrupt the cell membrane, induce oxidative stress and mitochondrial dysfunction, and eventually lead to Alzheimer’s disease (AD). Intervening with this cytotoxic aggregation process has been suggested as a potential therapeutic approach for AD and other protein misfolding diseases. Traditional Chinese Medicine (TCM) has been used to treat AD and related cognitive impairment for centuries with obvious efficacy. Extracts or active ingredients of TCMs have been reported to inhibit the aggregation and cytotoxicity of Aβ. However, there is a lack of systematic research on the anti-Aβ aggregation effects of TCM components. In this study, we performed a systematic screening to identify the active ingredients of TCM against the cytotoxic aggregation of Aβ42. Through a literature and database survey, we selected 19 TCM herbals frequently used in the treatment of AD, from which 76 major active chemicals without known anti-amyloid effects were further screened. This took place through two rounds of MTT-based screening detection of the cytotoxicity of these chemicals and their effects on Aβ42-induced cytotoxicity, respectively. Tetrahydroxystilbene-2-O-β-D-glucoside (TSG) and sinapic acid (SA) were found to be less toxic, and they inhibited the cytotoxicity of Aβ42. Further studies demonstrated that TSG and SA concentration-dependently attenuated the amyloidosis and membrane disruption ability of Aβ42. Thus, we identified two novel chemicals (TSG and SA) against the cytotoxic aggregation of Aβ42. Nonetheless, further exploration of their therapeutic potential is warranted.

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“…From the literature survey, minimum therapeutic doses of Syringic acid (SY) were finalized as 12.5, 25, 50 mg/kg/day and of Sinapic acid (SP) as 5, 10, 20 mg/kg/day orally (Li et.al.,2018, Shahmohamady et.al., 2018). Standard drug gabapentin 300 mg/kg/day p.o.…”

Section: Methodsmentioning

confidence: 99%

“…Sinapic acid (SP) is widely used in pharmaceutical and cosmetic industries because of its potent antioxidant, anti-inflammatory, preservative and antimicrobial activity (Raish et.al., 2019). SP is effectively proven to prevent memory loss, counterbalancing oxidative stress and beneficial in the treatment of Alzheimer’s disease (Shahmohamady et.al., 2018). In accordance with this literature survey, the present study was undertaken to evaluate effect of SY and SP on hyperalgesia and allodynia in neuropathy.…”

Section: Introductionmentioning

confidence: 99%

Attenuation of Hyperalgesia and Allodynia by some Phenolic Acids in Paclitaxel Induced Neuropathy

Pawar¹,

Upaganlawar²,

Upasani³

2021

Preprint

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Paclitaxel, an anticancer drug induced neuropathy is widely used animal model to evaluate new drugs in neuropathy. As oxidative stress is key contributor in pathogenesis of neuropathy, many phenolic acids with antioxidant potential are proven as neuroprotective. So,present work undertaken to evaluate effect of syringic acid and sinapic acid in paclitaxel induced neuropathy. We evaluated effect on mechanical and thermal hyperalgesia and allodynia which are vital signs of neuropathy. 4 weeks treatment by different doses of syringic acid and sinapic acid shown significant protective effect on hyperalgesia and allodynia in dose dependant manner assessed by Randello Selitto, hot plate, cold plate and Von Frey filament test. As these phenolic acids attenuates hyperalgesia and allodynia in neuropathy, can be therapeutically used in combination with current treatment of neuropathy.Summary statementHyperlagesia and allodynia are major signs of neuropathy and this article focus on reduction of hyperalgesia and allodynia by syringic and sinapic acid in neuropathy induced by paclitaxel.

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Effect of sinapic acid on memory deficits and neuronal degeneration induced by intracerebroventricular administration of streptozotocin in rats

Cited by 25 publications

References 65 publications

Evaluation of Some Phenolic Acids in Diabetic Neuropathy

Evaluation of Some Phenolic Acids in Diabetic Neuropathy

A Systematic Screening of Traditional Chinese Medicine Identifies Two Novel Inhibitors Against the Cytotoxic Aggregation of Amyloid Beta

Attenuation of Hyperalgesia and Allodynia by some Phenolic Acids in Paclitaxel Induced Neuropathy

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