Effect of Sleep Deprivation on Response to Immunizaton

Jagger, Janine; Puro, Vincenzo; Carli, Gabriella De

doi:10.1001/jama.288.12.1469

Cited by 429 publications

(170 citation statements)

References 8 publications

Supporting

Mentioning

159

Contrasting

Unclassified

Order By: Relevance

“…Cytokines synthesized by the immune system may play a role in normal sleep regulation, by increasing NREM sleep and decreasing REM sleep, and during inflammatory events, an increase in cytokine levels may intensify their effects on sleep regulation [91]. Current evidence suggests that acute and chronic sleep deprivation is associated with decreased proportions of natural killer cells [92], lower antibody titers following influenza virus immunization [93], reduced lymphokine-activated killer activity [94], and reduced interleukin-2 production [94]. Moreover, sleep deprivation may alter endocrine and metabolic functions, altering the normal pattern of cortisol release and contributing to alterations of "glucocorticoid feedback regulation" [95], glucose tolerance, and insulin resistance [96].…”

Section: Potential Implications Of Sleep Deprivation and Disruptionmentioning

confidence: 99%

Sleep in acute care units

BaHammam

2006

Sleep Breath

View full text Add to dashboard Cite

Patients in the acute care units (ACU) are usually critically ill, making them more susceptible to the unfavorable atmosphere in the hospital. One of these unfavorable factors is sleep disruption and deprivation. Many factors may affect sleep in the ACU, including therapeutic interventions, diagnostic procedures, medications, the underlying disease process, and noise generated in the ACU environment. Many detrimental physiological effects can occur secondary to noise and sleep deprivation, including cardiovascular stimulation, increased gastric secretion, pituitary and adrenal stimulation, suppression of the immune system and wound healing, and possible contribution to delirium. Over the past few years, many studies have endeavored to objectively assess sleep in the ACUs, as well as the effect of mechanical ventilation and circadian rhythm changes critically ill patients. At this time, therefore, it is important to review published data regarding sleep in ACUs, in order to improve the knowledge and recognition of this problem by health care professionals. We have therefore reviewed the methods used to assess sleep in ACUs, factors that may affect sleep in the ACU environment, and the clinical implications of sleep disruption in the ACU.

show abstract

Section: Potential Implications Of Sleep Deprivation and Disruptionmentioning

confidence: 99%

Sleep in acute care units

BaHammam

2006

Sleep Breath

View full text Add to dashboard Cite

show abstract

“…Laboratory and clinical studies have demonstrated that disruption of circadian rhythm results in immune system impairment [6,7], increased incidence and severity of infection [8], and worse outcomes in critically ill patients [9,10].…”

Section: Introductionmentioning

confidence: 99%

Circadian rhythm disruption in severe sepsis: the effect of ambient light on urinary 6-sulfatoxymelatonin secretion

et al. 2012

View full text Add to dashboard Cite

show abstract

“…En los humanos está demostrado que una noche de privación de sueño después de recibir una vacuna de hepatitis A disminuye la producción de anticuerpos, mientras que la respuesta inmune adaptativa es mejor si el individuo duerme después de la vacunación, ya que el medio proinfl amatorio durante el sueño funciona como adyuvante. 19 La activación inmune, la síntesis de proteínas y la proliferación celular, así como el aporte de energía y los cambios endocrinos que ocurren durante el sueño ayudan a mantener en buen estado al sistema inmune. 20 En animales infectados experimentalmente se demostró que la mortalidad disminuye si tienen un sueño completo después del desafío infeccioso, mientras que su privación los conduce a septicemia o, incluso, la muerte.…”

Section: Sueño Y Sistema Inmuneunclassified

Sueño y sistema inmune

Rico-Rosillo

Vega-Robledo

2018

RAM

View full text Add to dashboard Cite

Este artículo debe citarse como: Rico-Rosillo MG, Vega-Robledo GB. Sueño y sistema inmune. Rev Alerg Mex. 2018;65(2):160-170 ORCID María Guadalupe Rico-Rosillo, ORCID: 0000-0002-3117-1617; Gloria Bertha Vega-Robledo, ORCID: 0000-0002-5816-1910 AbstractSleep is a process that occupies one third part of the life of the human being, and it is essential in order for the individual to be able to maintain body homeostasis. It emerges as an important regulator of the immune system since, during sleep, the necessary functions to maintain its balance are carried out. On the other hand, decreased sleep has deleterious eff ects that alter the metabolism and produce an increase in the secretion of C-reactive protein, interleukin (IL)-6 and tumor necrosis factor (TNF). These cytokines activate NF-κB; therefore, sleep disturbance can be a risk factor for the development of chronic infl ammatory and metabolic diseases. Pro-infl ammatory cytokines IL-1, IL-6 and TNF increase non-rapid eye movement sleep, whereas anti-infl ammatory cytokines such as IL-4 and IL-10 decrease it. Sleep can modify the immune system function by inducing changes in the hypothalamus-pituitary-adrenal axis and the sympathetic nervous system. In turn, the circadian rhythm of hormones such as cortisol and adrenaline, which have a nocturnal decrease, favors diff erent activities of the immune system. The purpose of the present review is to address diff erent aspects of sleep and their relationship with the immune system.

show abstract

Effect of Sleep Deprivation on Response to Immunizaton

Cited by 429 publications

References 8 publications

Sleep in acute care units

Sleep in acute care units

Circadian rhythm disruption in severe sepsis: the effect of ambient light on urinary 6-sulfatoxymelatonin secretion

Sueño y sistema inmune

Contact Info

Product

Resources

About