Effect of socket grafting with deproteinized bone mineral: An <scp>RCT</scp> on dimensional alterations after 6 months

Tomasi, Cristiano; Donati, Mauro; Cecchinato, Denis; Szathvary, Isacco; Corrà, Enrico; Lindhe, Jan

doi:10.1111/clr.13141

Cited by 27 publications

(37 citation statements)

References 24 publications

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“…The buccal and lingual/palatal volume changes measured in this study are not consistent with those reported by Tomasi et al (), in which buccal and palatal relative volume reduction was 11.0% and 9.0%, respectively. In the present study, buccal relative volume increased by 8.66% and 2.42% and lingual/palatal decreased by 2.98% and 0.76% in the maxilla and mandible, respectively.…”

Section: Discussioncontrasting

confidence: 99%

“…Though the width and height of buccal bone decreased, middle ridge height in socket increased, and for this reason, the buccal relative volume increased. Furthermore, Tomasi et al () reported that the thickness of buccal bone influenced the degree of volume reduction; the diminution of buccal volume at sites with thin (≤1 mm) bone plate was three times greater than at sites with a thicker (>1 mm) bone; in the present study, the buccal bone plate thickness was 1.85 ± 1.15 mm.…”

Section: Discussionsupporting

confidence: 52%

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Changes in alveolar process dimensions following extraction of molars with advanced periodontal disease: A clinical pilot study

Zhao

Wei

et al. 2019

Clinical Oral Implants Res

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Objective: To use cone beam computed tomography (CBCT) to assess the alterations of socket dimensions after a 6-month healing period following molar extraction.Materials and methods: Seventeen molars were extracted due to advanced periodontitis. CBCT scans were taken immediately after extraction and once more 6 months later. Superimposition of CBCT images was used to measure the following:horizontal changes at extraction sites at three corono-apical levels (−1, −3, and −5 mm) below the bone crest, three mesio-distal levels (mesial, central, and distal), vertical changes at nine regions of the alveolar crest, and alveolar bone volume. Results: The width of the central crests at −1 mm decreased by 0.59 and 0.72 mm in the buccal and 0.27 and 0.02 mm in the lingual, in the maxilla and mandible, respectively. No statistically significant decreases in the ridge height were observed except in the disto-palatal region with a 1.11 mm decrease in the maxilla (p < 0.05). Heights of the buccal and lingual bone plates decreased significantly and ranged from 0.56 to 1.38 mm in the mandible after 6 months of healing (p < 0.05). Overall, ridge height changes were not significantly different between the maxilla and mandible (p > 0.05) and no significant volumetric bone loss occurred in either maxillary or mandibular sockets after 6 months of healing.Conclusions: Socket dimensions of molars with advanced periodontal disease showed a significant increase at the middle-central portion, although there were no significant changes of horizontal width 6 months following the procedures. K E Y W O R D Sbone, cone beam computed tomography, flapless, resorption, socket healing | 325 ZHAO et Al. al., 2003;Sanz et al., 2010; Tomasi et al., 2010). Schropp, Wenzel, Kostopoulos, andKarring (2003) investigated contour changes of the alveolar processes of posterior extraction sites by measuring stone casts and discovered a reduction in width of the residual alveolar ridge of up to 50% (5.0-7.0 mm) during a 12-month healing period, of which two-thirds of the reduction occurred within the first 3 months of healing. Systematic reviews of mixed anterior and posterior extraction socket changes indicated an approximate 3.8 mm horizontal

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 52%

Changes in alveolar process dimensions following extraction of molars with advanced periodontal disease: A clinical pilot study

Zhao

Wei

et al. 2019

Clinical Oral Implants Res

View full text Add to dashboard Cite

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“…Another RCT with a negative control group and a DBBM test group (Sbordone et al, ) presented similar findings when compared to a previous study (Barone et al, ), always demonstrating an overall reduction from the original volume (expressed in mm 3 ), with a reduction of 400 mm 3 at control group and 210 mm 3 at DBBM group after 5 months. A recent RCT evaluating soft tissue changes in posterior sites after 6 months (Tomasi et al, ) found interesting results, where the DBBM‐C showed a soft tissue remodeling of 21.3%, a similar amount in the negative control group (20%). In the aforementioned studies, the sites presented thick buccal bone wall, commonly observed in posterior regions, what does not favor the identification of differences between treatments.…”

Section: Discussionmentioning

confidence: 99%

“…CBCT analysis from the patients of the present study (Llanos et al, 2019) also demonstrated a small horizontal bone loss at 1mm (−1.60 ± 0.82 for DBBM-C and − 1.37 ± 0.84 for DBBM There are few clinical studies in the literature investigating soft tissue contour changes after tooth extraction. The existing studies also included premolars and mandibular teeth (Barone et al, 2016;Sbordone et al, 2017;Schneider et al, 2014;Thalmair et al, 2013;Tomasi et al, 2018), whereas the present study evaluated exclusively anterior maxillary teeth (canines and incisors), focusing in the esthetic outcomes. The previous studies in dental literature have also a limited sample size, not reaching more than 14 patients per group (Barone et al, 2016) and 40 patients per study (Schneider et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Despite the large number of studies investigating the impact of alveolar ridge preservation techniques (ARP) on radiographic parameters, few studies investigated its consequences on changes of the soft tissue contour (Barone et al, 2016;Clozza, Biasotto, Cavalli, Moimas, & Lenarda, 2012;Fickl et al, 2009;Sbordone et al, 2017;Schneider et al, 2014;Tomasi et al, 2018). Recent studies combined data from maxillary and mandibular sites and also included premolars.…”

Section: Introductionmentioning

confidence: 99%

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Deproteinized bovine bone mineral is non‐inferior to deproteinized bovine bone mineral with 10% collagen in maintaining the soft tissue contour post‐extraction: A randomized trial

Sapata

Llanos

Neto

et al. 2020

Clinical Oral Implants Res

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Objectives To test the non‐inferiority of demineralized bovine bone mineral (DBBM) compared to demineralized bovine bone mineral with 10% collagen (DBBM‐C) for the maintenance of the soft tissue contour after tooth extraction in the esthetic zone. Material and Methods Sixty‐five patients randomly received ridge preservation at a single site in the anterior maxilla with DBBM or DBBM‐C. Both, DBBM and DBBM‐C, were covered with a collagen matrix. Profilometric analyses were performed at baseline (BL), immediately after treatment (PO), and at 4 months (FU; day of implant placement). The main outcome was the horizontal mean change (HC) at the buccal aspect. The measurements also included changes of the estimated soft tissue thickness (eTT) at 1, 3, and 5 mm below the buccal gingival margin. Descriptive analysis was performed, and differences between groups were analyzed using independent samples t test. The non‐inferiority test was performed for HC. Results At 4 months, the horizontal mean change (HC) was −1.43 mm (±0.53 mm) (DBBM‐C) and −1.32 mm (±0.53 mm) (DBBM). Change of the estimated soft tissue thickness (eTT) between baseline (BL) and four months of follow‐up (FU) at 1, 3, and 5 mm amounted to −4.58 mm (±2.02 mm), −2.40 mm (±0.97 mm), and −1.37 mm (±0.78 mm) for DBBM‐C and to −4.12 mm (±1.80 mm), −2.09 mm (±0.91 mm), and −1.23 mm (±0.72 mm) for DBBM. The differences between the groups were not statistically significantly for any of the outcome measures (p > .05). Conclusions DBBM is non‐inferior to DBBM‐C for the maintenance of the soft tissue contour 4 months after tooth extraction.

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Efficacy of biologics for alveolar ridge preservation/reconstruction and implant site development: An American Academy of Periodontology best evidence systematic review

Amo¹,

Monje

2022

Journal of Periodontology

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Background: The use of biologics may be indicated for alveolar ridge preservation (ARP) and reconstruction (ARR), and implant site development (ISD). The present systematic review aimed to analyze the effect of autologous bloodderived products (ABPs), enamel matrix derivative (EMD), recombinant human platelet-derived growth factor-BB (rhPDGF-BB), and recombinant human bone morphogenetic protein-2 (rhBMP-2), on the outcomes of ARP/ARR and ISD therapy (i.e., alveolar ridge augmentation [ARA] and maxillary sinus floor augmentation [MSFA]). Methods: An electronic search for eligible articles published from January 2000 to October 2021 was conducted. Randomized clinical trials evaluating the efficacy of ABPs, EMD, rhBMP-2, and rhPDGF-BB for ARP/ARR and ISD were included according to pre-established eligibility criteria. Data on linear and volumetric dimensional changes, histomorphometric findings, and a variety of secondary outcomes (i.e., clinical, implant-related, digital imaging, safety, and patientreported outcome measures [PROMs]) were extracted and critically analyzed. Risk of bias assessment of the selected investigations was also conducted. Results: A total of 39 articles were included and analyzed qualitatively. Due to the high level of heterogeneity across studies, quantitative analyses were not feasible. Most studies in the topic of ARP/ARR revealed that the use of biologics rendered similar results compared with conventional protocols. However, when juxtaposed to unassisted healing or socket filling using collagen sponges, the application of biologics did contribute to attenuate post-extraction alveolar ridge atrophy in most investigations. Additionally, histomorphometric outcomes were positively influenced by the application of biologics. The use of biologics in ARA Both authors contributed equally to this study.

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Effect of socket grafting with deproteinized bone mineral: An RCT on dimensional alterations after 6 months

Cited by 27 publications

References 24 publications

Changes in alveolar process dimensions following extraction of molars with advanced periodontal disease: A clinical pilot study

Changes in alveolar process dimensions following extraction of molars with advanced periodontal disease: A clinical pilot study

Deproteinized bovine bone mineral is non‐inferior to deproteinized bovine bone mineral with 10% collagen in maintaining the soft tissue contour post‐extraction: A randomized trial

Efficacy of biologics for alveolar ridge preservation/reconstruction and implant site development: An American Academy of Periodontology best evidence systematic review

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