The presence of hazardous metals, such as nickel and copper, has been identified in the effluents of the textile industries. Due to such hazardous components, this waste water exhibits a significant chemical oxygen demand (COD). Various methods are used to reduce the COD presence in the effluents. This investigation employs hydrodynamic cavitation, to decrease COD levels potentially. This reduction is achieved by implementing different orifice plate designs, including 3-star pattern, 3-circular hole pattern, 5-star pattern, and 5-circular hole pattern, as part of an innovative strategy. According to current investigations, implementing the 5-circular hole layout significantly reduced of COD by 49.14%. In contrast, using the 5-star design yielded a low drop of 34.15% COD. These experimental findings indicated that the most effective orifice plate for removing COD from textile wastewater was a circular design with 5- holes.