The objective of this paper is to perform the design practice for the structures of stilt building construction, based on the seismic design methodology. Firstly, the design requirements and design constraints are determined according to the site of the building within the Banjarmasin city of the wetlands area and compared with the other zones. Based on the latest Indonesia earthquake design code, the city of Banjarmasin is in the lightest earthquake hazard area so it is considered to neglect the seismic load in earthquake resistance. Actually, South Kalimantan region, mostly as wetland area, has experienced earthquakes several times. On the entire area, the land has a soft soil condition which has the potential to damage buildings in the event of an earthquake due to the amplification of earthquake vibrations. Then, a practical design chart of the basic earthquake load response spectrum has been analyzed. Apart from that, a design practice of varying soil strata is generally considered by the latest code for earthquake engineering design SNI-1726SNI- -2019 The results indicate that the earthquake response spectrum design charts for all areas in the low risk zone, as the soft soil ground strata, affected into the seismic load design of earthquake force should be taking into account for design practice. The base shear for the stilt structure of multy story building should be designed as approximately one thirteith of total weight of the building structure.