Effect of solvent concentration on the extraction kinetics and diffusivity of Cyclosporin A in the fungus <i>Tolypocladium inflatum</i>

Ly, May; Margaritis, Argyrios; Jajuee, Babak

doi:10.1002/bit.21180

Cited by 17 publications

(8 citation statements)

References 17 publications

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“…To evaluate the mass transfer rate of extracted solute from the solid matrix surface to the bulk liquid phase, a kinetic approach based on the Fick's law can be used (Ly et al . 2007):…”

Section: Mathematical Modelsmentioning

confidence: 99%

MODELING SOLID–LIQUID EXTRACTION KINETICS OF TRANS‐RESVERATROL AND TRANS‐ε‐VINIFERIN FROM GRAPE CANE

Karacabey

Bayındırlı

Artık

et al. 2011

J Food Process Engineering

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Solid-liquid extraction of resveratrol and viniferin from grape cane samples was described by using first-order kinetic model, Peleg's model, two-site kinetic model and modified Gompertz equation. Goodness of fits of the models were evaluated by comparing the adjusted determination coefficient and root mean square error and mean percentage error values. Although the two-site kinetic model with four parameters described the data better, Peleg's model, with only two parameters, could explain the data with a slight loss of goodness of fit. The modified Gompertz equation showed the worst performance for describing the solid-liquid extraction of stilbenes. PRACTICAL APPLICATIONSThe present study introduces the comparison of well-known models applied to explain extraction kinetic of stilbene compounds of grape cane and to determine the best model with its justifications. Mathematical models provide information about the system and/or process to which they are applied. In design and/or process application stages, any information about that process and/or system has crucial importance because in the decision stages, this know-how helps the designers and researchers find the best design parameters and the most effective process conditions to optimize purposes. Mathematical models are accepted as the most economical ways for these purposes. bs_bs_banner Journal of Food Process Engineering

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“…To evaluate the mass transfer rate of extracted solute from the solid matrix surface to the bulk liquid phase, a kinetic approach based on the Fick's law can be used (Ly et al . 2007):…”

Section: Mathematical Modelsmentioning

confidence: 99%

MODELING SOLID–LIQUID EXTRACTION KINETICS OF TRANS‐RESVERATROL AND TRANS‐ε‐VINIFERIN FROM GRAPE CANE

Karacabey

Bayındırlı

Artık

et al. 2011

J Food Process Engineering

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“…It was found that the conventional extraction process showed a first-order reaction release pattern while the combined process followed second-order kinetics possibly because of easy disruption of relatively rigid algal cell membranes [14]. It was observed that during the conventional extraction process the external mass transfer resistance was important since generally the dissolution of lipids by the solvent and the external mass transfer occur in the opposite direction in the extraction processes, including the penetration of outer cell walls by the solvent [15]. It was also interesting that two steps were observed in extracting the lipids during the conventional extraction process: the initial slow stage for the first 1 hr and the later faster stage after 2–5 hrs.…”

Section: Resultsmentioning

confidence: 99%

Enhancement of Lipid Extraction from Marine Microalga,ScenedesmusAssociated with High-Pressure Homogenization Process

Cho

Choi

et al. 2012

Journal of Biomedicine and Biotechnology

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Marine microalga, Scenedesmus sp., which is known to be suitable for biodiesel production because of its high lipid content, was subjected to the conventional Folch method of lipid extraction combined with high-pressure homogenization pretreatment process at 1200 psi and 35°C. Algal lipid yield was about 24.9% through this process, whereas only 19.8% lipid can be obtained by following a conventional lipid extraction procedure using the solvent, chloroform : methanol (2 : 1, v/v). Present approach requires 30 min process time and a moderate working temperature of 35°C as compared to the conventional extraction method which usually requires >5 hrs and 65°C temperature. It was found that this combined extraction process followed second-order reaction kinetics, which means most of the cellular lipids were extracted during initial periods of extraction, mostly within 30 min. In contrast, during the conventional extraction process, the cellular lipids were slowly and continuously extracted for >5 hrs by following first-order kinetics. Confocal and scanning electron microscopy revealed altered texture of algal biomass pretreated with high-pressure homogenization. These results clearly demonstrate that the Folch method coupled with high-pressure homogenization pretreatment can easily destruct the rigid cell walls of microalgae and release the intact lipids, with minimized extraction time and temperature, both of which are essential for maintaining good quality of the lipids for biodiesel production.

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“…CyA is an intracellular metabolite located in the fungal vacuole (Ly et al 2007). It is produced in liquid medium, and the filtration step in the extraction process allows determining the amount of mycelium (dry weight) for each sample.…”

Section: Cyclosporine a Analysismentioning

confidence: 99%

Production of fumonisins by endophytic strains of Tolypocladium cylindrosporum and its relation to fungal virus infection

2017

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Fumonisins were first discovered in Fusarium verticillioides, a fungus associated to disease and asymptomatic infections in maize. Afterwards, other fungal taxa have been found to produce fumonisins. The entomopathogenic ascomycete Tolypocladium cylindrosporum has been isolated from soil and also as an endophyte from leaves of grasses. The objectives of this work were to determine the in vitro production of fumonisin B (FB) mycotoxins and the immunosuppressive compound cyclosporine A (CyA) in several strains of T. cylindrosporum, and to examine the effect of fungal virus infection and temperature in FB production. FB was detected in 30% of the strains, ranging from 0.16 to 5.52 μg cm in solid media, and FB was detected in 78% of the strains, ranging from 0.764 to 40.92 μg cm. CyA was not detected in any strain. The mean FB concentration of the endophytic strain Tc37W was three times greater (p < 0.05) than that of any other strain. Up to 34% more of FB was detected in strains infected by the virus TcV3 than in the corresponding virus-free versions. The effect of temperature on FB content was interactively significantly dependent on fungal strain and growth medium; in the YES medium, the FB of virus-infected strains Tc37-1V and Tc37W increased by 67 and 16%, respectively, at 26 °C as compared to 20 °C. The FB concentration in some fungal strains was similar to that in fungi associated to food and feed intoxications.

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Effect of solvent concentration on the extraction kinetics and diffusivity of Cyclosporin A in the fungus Tolypocladium inflatum

Cited by 17 publications

References 17 publications

MODELING SOLID–LIQUID EXTRACTION KINETICS OF TRANS‐RESVERATROL AND TRANS‐ε‐VINIFERIN FROM GRAPE CANE

MODELING SOLID–LIQUID EXTRACTION KINETICS OF TRANS‐RESVERATROL AND TRANS‐ε‐VINIFERIN FROM GRAPE CANE

Enhancement of Lipid Extraction from Marine Microalga,ScenedesmusAssociated with High-Pressure Homogenization Process

Production of fumonisins by endophytic strains of Tolypocladium cylindrosporum and its relation to fungal virus infection

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