Effect of soya beans and soya beans fermented with<i>Schizophyllum commune</i>Fr. On ethanol-induced gastric ulcer in Sprague-Dawley rats

Abdullah, Noorlidah; Gopal, D. M. Venu; Abdulla, Mahmood Ameen

doi:10.1556/aalim.41.2012.3.5

Cited by 6 publications

(4 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, its stimulating effect on mucus secretion has remained controversy [66]. In addition to the effectiveness of omeprazole on acid-dependent gastric lesion, it is also effective on acid-independent gastric model [67]–[70]. Ethanol, as it was shown in this study, causes severe macroscopic lesion with histological changes such as extensive edema, leukocyte infiltration of the submucosal layer and loss of integrity of gastroepithelium along with the impairment of gastric mucosa [30], [42].…”

Section: Discussionmentioning

confidence: 97%

Gastroprotection Studies of Schiff Base Zinc (II) Derivative Complex against Acute Superficial Hemorrhagic Mucosal Lesions in Rats

et al. 2013

View full text Add to dashboard Cite

BackgroundThe study was carried out to assess the gastroprotective effect of the zinc (II) complex against ethanol-induced acute hemorrhagic lesions in rats.Methodology/Principal FindingThe animals received their respective pre-treatments dissolved in tween 20 (5% v/v), orally. Ethanol (95% v/v) was orally administrated to induce superficial hemorrhagic mucosal lesions. Omeprazole (5.790×10−5 M/kg) was used as a reference medicine. The pre-treatment with the zinc (II) complex (2.181×10−5 and 4.362×10−5 M/kg) protected the gastric mucosa similar to the reference control. They significantly increased the activity levels of nitric oxide, catalase, superoxide dismutase, glutathione and prostaglandin E2, and decreased the level of malondialdehyde. The histology assessments confirmed the protection through remarkable reduction of mucosal lesions and increased the production of gastric mucosa. Immunohistochemistry and western blot analysis indicated that the complex might induced Hsp70 up-regulation and Bax down-regulation. The complex moderately increased the gastroprotectiveness in fine fettle. The acute toxicity approved the non-toxic characteristic of the complex (<87.241×10−5 M/kg).Conclusion/SignificanceThe gastroprotective effect of the zinc (II) complex was mainly through its antioxidant activity, enzymatic stimulation of prostaglandins E2, and up-regulation of Hsp70. The gastric wall mucus was also a remarkable protective mechanism.

show abstract

Section: Discussionmentioning

confidence: 97%

Gastroprotection Studies of Schiff Base Zinc (II) Derivative Complex against Acute Superficial Hemorrhagic Mucosal Lesions in Rats

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Results of this investigation confirmed verbal gavage RM defends gastric epithelial via discharging extra mucous against extensive damage via ethanol. In specific, RM has revealed substantial antioxidant activity formerly ( Abdullah et al, 2012 , Aboul Naser et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

“…Subsequently rats sacrifice, blood withdrew from intracardial perforation. Sera separated biochemical experiments ( Abdullah et al, 2012 , Mughrabi et al, 2011 ).…”

Section: Materials and Methodologymentioning

confidence: 99%

Anti-ulcer effect of Ranunculus millefoliatus on absolute alcohol-induced stomach ulceration

Abdoulrahman

2023

Saudi Journal of Biological Sciences

View full text Add to dashboard Cite

“…Omeprazole was purchased from a dispensary dissolved in 10% Tween 20 forced feeding by mouth to rats at a dosage of 20 mg/kg (5 mL/kg), as recommended by several investigators'. [10][11][12] Omeprazole was purchased from the pharmacy, ketamine, and xylazine and was purchased from a veterinary clinic.…”

Section: Chemicals and Reagentsmentioning

confidence: 99%

Green Synthesis of Gold Nanoparticles Using Zingiber Officinale Rhizomes Aqueous Extract and its Gastroprotective Activity Against Ethanol-Produced Stomach Ulcer in Rodents

Shareef

Hadi

‎

et al. 2022

Cihan U Erbil SCI J

View full text Add to dashboard Cite

Synthesis of gold nanoparticles exhibition wide range of bioactivities and was conventionally used for the remedy of numerous disorders. Our study aims to measure the gastroprotective effect of synthesized gold nanoparticles on absolute ethanol-induced stomach ulceration in rats. The rats were noticeably administered with two doses of gold nanoparticles (175 ppm and 350 ppm) with absolute alcohol and showed a significant improvement in the adverse effect of ethanol-produced stomach damage as confirmed by decreasing ulcer index and raising % of ulcer prevention. Increased mucus pH of stomach content reduced ulcerated portion, condensed or nonappearance of edema, and white blood cells permeation subcutaneous layer. In gastric tissue homogenate, synthesized gold nanoparticles presented a substantial increase in superoxide dismutase (SOD), catalase (CAT) actions, and a substantial lessening of malondialdehyde (MDA) amount. Besides, gold nanoparticle increases the intensity of periodic acid Schiff stained (PAS) of the gastric epithelium of the stomach. Gold nanoparticles confirmed gastro-protective effects which might be qualified to its antioxidant, increase mucus secretion, increase endogenous enzymes (SOD and CAT), and reduce MDA quantity.

show abstract

Effect of soya beans and soya beans fermented withSchizophyllum communeFr. On ethanol-induced gastric ulcer in Sprague-Dawley rats

Cited by 6 publications

References 21 publications

Gastroprotection Studies of Schiff Base Zinc (II) Derivative Complex against Acute Superficial Hemorrhagic Mucosal Lesions in Rats

Gastroprotection Studies of Schiff Base Zinc (II) Derivative Complex against Acute Superficial Hemorrhagic Mucosal Lesions in Rats

Anti-ulcer effect of Ranunculus millefoliatus on absolute alcohol-induced stomach ulceration

Green Synthesis of Gold Nanoparticles Using Zingiber Officinale Rhizomes Aqueous Extract and its Gastroprotective Activity Against Ethanol-Produced Stomach Ulcer in Rodents

Contact Info

Product

Resources

About