Effect of standardized root extract of ashwagandha (<i>Withania somnifera</i>) on well‐being and sexual performance in adult males: A randomized controlled trial

Chauhan, Sanjaya; Srivastava, Manoj; Pathak, Anklesh Kumar

doi:10.1002/hsr2.741

Cited by 17 publications

(10 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The oral Administration of ARE has been previously reported to promote an increase in male testosterone among human participants (ref. 35), although the mechanisms still need to be explored, and the results of this study provide additional evidence that ARE may be administered for therapeutic purposes without inducing deleterious effects on the fertility and reproductive health of males. We also observed improvements in serum testosterone (p=0.012), DHT, Prolactin, FSH, and LH levels.…”

Section: )mentioning

confidence: 86%

Role of Eight-Week Therapy with Ashwagandha Root Extract in Improving Sexual Health in Healthy Men: Findings of a Prospective, Randomized, Double-Blind, Placebo-Controlled Study

Mutha,

Beldar,

Mulay

et al. 2023

Preprint

View full text Add to dashboard Cite

Ashwagandha, a traditional Indian Ayurvedic remedy, an adaptogen, can improve sexual dysfunction in men and women. This 8-week prospective, double-blind, randomized, placebo-controlled study evaluated the efficacy and safety of Ashwagandha Root Extract (ARE) on improving sexual health in healthy adult men based on Satisfying Sexual Events (SSEs), Sexual Desire Inventory (SDI-2), International Index of Erectile functon(IIEF) score, semen parameters and the Quality Of Life (QOL) using the SF-12 tool. A total of 100 healthy men aged 30 to 50 years were randomly assigned to receive ARE 300 mg twice daily (n=50), or identical placebo (n=50) in a 1:1 ratio for 8 weeks. Study assessments were done at baseline, week 2, week 4, and week 8. Three participants from ARE and four participants from placebo group were excluded due to follow-up loss. The efficacy analyses were done on Per-Protocol (PP) dataset of 93, whereas safety analyses were done on all 100 participants. Significant improvements were observed with ARE for semen volume (p=0.005), sperm number (p=0.006), sperm concentration (p=0.007), and sperm morphology (p=0.007). The improvement in scores were better with ARE for SDI-2 (p<0.05), orgasm and sexual desire domains of IIEF (p<0.05), and SF-12 (p<0.0001). No patients reported any adverse events.

show abstract

Section: )mentioning

confidence: 86%

Role of Eight-Week Therapy with Ashwagandha Root Extract in Improving Sexual Health in Healthy Men: Findings of a Prospective, Randomized, Double-Blind, Placebo-Controlled Study

Mutha,

Beldar,

Mulay

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…When compared to a placebo, ashwagandha root extract consumption was related to a statistically significant rise in total DISFM scores. It was also linked to a statistically significant increase in serum testosterone levels [106].…”

Section: Treatment Based On Plants and Other Natural Productsmentioning

confidence: 95%

A Review on Risk Factors, Diagnostic Innovations, and Plant Based Therapies for the Management of Erectile Dysfunction

Alrumaihi,

Raut,

Yahia

et al. 2024

Uro

View full text Add to dashboard Cite

Men of all ages frequently experience erectile dysfunction (ED) or impotence, and it is a difficult health issue that adversely affects the quality of life of those who experience it. There are multiple types of treatment strategies for ED available, depending on the origin and severity of ED, as well as any underlying medical issues. However, these therapeutics are known to have a number of negative health effects. In contrast, plant-based treatments are more effective for managing diseases due to their ability to modulate biological processes like inflammation, oxidative stress, and cell signaling molecules. Many medicinal plants have been reported to be quite helpful in the improvement of ED. In this review, ED and its causes, diagnostic methods, treatment strategies, and some of the most potent plant-based interventions against ED are discussed in greater detail, along with a description of their mechanisms of action and a brief discussion of approaches to increase their efficacy, with a focus on the management of ED using herbal interventions as complementary and alternative medicines. While there is hope that medicinal plants could provide lead substances for erectile dysfunction medications, additional investigation is necessary to ascertain the efficacy and security of these prospective treatments.

show abstract

“…Like any botanical drugs and pharmaceutical drugs, there have been some adverse effects reported after w. Somnifera consumption. In a clinical trial, seven adult males reported feeling sleepiness, mild abdominal and joint pain after consuming ashwagandha capsule (Chauhan et al, 2022). Withania somnifera is still not approved by the U.S. Food and Drug Administration (FDA) and has not been used legally to treat diseases on large scale.…”

Section: Role Of W Somnifera In Covid-19 Infectionmentioning

confidence: 99%

The immunomodulatory role of withania somnifera (L.) dunal in inflammatory diseases

Alanazi

Elfaki

2023

Front. Pharmacol.

View full text Add to dashboard Cite

Withania somnifera (L.) Dunal (Solanaceae) (also known as Ashwagandha) is a botanical drug that has been used for centuries to treat many chronic diseases like high blood pressure, arthritis, diabetes, Alzheimer’s disease, and depression. As many botanical drugs, w. Somnifera possesses anti-inflammatory, antioxidant, anticarinogenic, anti-diabetic, and anti-asthmatic properties. W. somnifera is often compared to the ginseng plant due to its ability to reduce stress, improve cognitive functions (e.g., memory), and promote a healthy immune system. It promotes immunomodulatory effects whose function is to balance the humoral and cellular responses of the adaptive immune system. The therapeutic effect of w. Somnifera is attributed to active ingredients like alkaloids, steroidal lactones (such as withanolides, withaferins), and steroidal saponins. Although w. Somnifera is safe and highly recommended for treating various diseases, the current knowledge and understanding of its operational mechanisms are limited. One of the proposed mechanisms states that w. Somnifera promotes cellular-mediated immunity or initiates chemical interactions that contribute to therapeutic effects. Withania somnifera has been shown to play a significant role in immunological diseases by modulating several cytokines, increasing T-cell proliferation and enhancing macrophages functions. In this review, we will discuss the latest therapeutic effects of w. Somnifera on a number of diseases through modulating immunological markers and which specific components of w. Somnifera induce these therapeutic activities. We will also focus on the chemical properties in w. Somnifera components and their immunomodulatory role in type 2 allergic diseases where type 2 inflammation is highly imbalanced.

show abstract

Effect of standardized root extract of ashwagandha (Withania somnifera) on well‐being and sexual performance in adult males: A randomized controlled trial

Cited by 17 publications

References 36 publications

Role of Eight-Week Therapy with Ashwagandha Root Extract in Improving Sexual Health in Healthy Men: Findings of a Prospective, Randomized, Double-Blind, Placebo-Controlled Study

Role of Eight-Week Therapy with Ashwagandha Root Extract in Improving Sexual Health in Healthy Men: Findings of a Prospective, Randomized, Double-Blind, Placebo-Controlled Study

A Review on Risk Factors, Diagnostic Innovations, and Plant Based Therapies for the Management of Erectile Dysfunction

The immunomodulatory role of withania somnifera (L.) dunal in inflammatory diseases

Contact Info

Product

Resources

About