Effect of Static Magnetic Fields on the Osseointegration of Immediately Placed Implants

Siadat, Hakimeh; Bassir, Seyed Hossein; Alikhasi, Marzieh; Shayesteh, Y. Soleymani; Khojasteh, Arash; Monzavi, Abbas

doi:10.1097/id.0b013e31826dcc2f

Cited by 16 publications

(11 citation statements)

References 31 publications

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“…In animal models, moderate SMFs have been found to prevent and treat osteoporosis [Zhang et al, 2018a], promote fracture healing, repair bone defects [Aydin and Bezer, 2011; He et al, 2019], and mitigate osteoarthritis [Rogachefsky et al, 2004]. A clinical trial showed that moderate SMFs accelerated osseointegration of implants [Siadat et al, 2012]. However, few studies have paid attention to the effects of high SMF on the skeletal system.…”

Section: Introductionmentioning

confidence: 99%

Static Magnetic Field (2–4 T) Improves Bone Microstructure and Mechanical Properties by Coordinating Osteoblast/Osteoclast Differentiation in Mice

Yang

Wang

Zhang

et al. 2021

Bioelectromagnetics

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Static magnetic field (SMF), with constant magnetic field strength and direction, has a long history of basic and clinical research in bone biology. Numerous studies demonstrate that exposure to moderate SMF (1 mT-1 T) can increase bone mass and bone density. However, few studies pay attention to the effects of high SMF (>1 T) on the skeletal system. To investigate the physiological effects of high SMF on bone, mice were exposed to 2-4 T SMF for 28 days. Bone microstructure and mechanical properties were examined. The activity of osteoblasts and osteoclasts involved in bone remodeling was evaluated in vivo and in vitro. Compared with the unexposed group, 2-4 T significantly improved the femoral microstructure and tibial mechanical properties. For bone remodeling in vivo, the number of osteoblasts and bone formation was increased, and the osteoclastic number was decreased by 2-4 T. Moreover, the expression of marker proteins in the femur and concentrations of biochemical indicators in serum involved in bone formation were elevated and bone resorption was reduced under 2-4 T SMF. In vitro, osteoblast differentiation was promoted, and the osteoclastic formation and bone resorption ability were inhibited by 2 T SMF. Overall, these results demonstrate that 2-4 T SMF improved bone microarchitecture and strength by stimulating bone formation and restraining bone resorption, and imply that high SMF might become a potential biophysical treatment modality for bone diseases with abnormal bone remodeling.

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Section: Introductionmentioning

confidence: 99%

Static Magnetic Field (2–4 T) Improves Bone Microstructure and Mechanical Properties by Coordinating Osteoblast/Osteoclast Differentiation in Mice

Yang

Wang

Zhang

et al. 2021

Bioelectromagnetics

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“…Rare-earth magnets, which generate SMFs, have been used in magnetic retention appliances in implant- or tooth-retained overdentures [ 8 ], maxillofacial prostheses after trauma and cancer surgery [ 9 ], as well as in orthodontic treatments such as space closure, molar distalization, intrusion, the traction of impacted teeth, and palatal expansion [ 5 ]. SMFs increased implant stability and reduced bone loss during the initial weeks of healing [ 10 ]. Recently, we demonstrated that exposing sandblasted, large-grit, acid-etched-treated titanium implants to 15-mT SMFs triggered faster early peri-implant bone formation in rabbits [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Static magnetic fields promote osteoblastic/cementoblastic differentiation in osteoblasts, cementoblasts, and periodontal ligament cells

Kim

Park

Kwon

et al. 2017

J Periodontal Implant Sci

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PurposeAlthough static magnetic fields (SMFs) have been used in dental prostheses and osseointegrated implants, their biological effects on osteoblastic and cementoblastic differentiation in cells involved in periodontal regeneration remain unknown. This study was undertaken to investigate the effects of SMFs (15 mT) on the osteoblastic and cementoblastic differentiation of human osteoblasts, periodontal ligament cells (PDLCs), and cementoblasts, and to explore the possible mechanisms underlying these effects.MethodsDifferentiation was evaluated by measuring alkaline phosphatase (ALP) activity, mineralized nodule formation based on Alizarin red staining, calcium content, and the expression of marker mRNAs assessed by reverse transcription polymerase chain reaction (RT-PCR). Signaling pathways were analyzed by western blotting and immunocytochemistry.ResultsThe activities of the early marker ALP and the late markers matrix mineralization and calcium content, as well as osteoblast- and cementoblast-specific gene expression in osteoblasts, PDLCs, and cementoblasts were enhanced. SMFs upregulated the expression of Wnt proteins, and increased the phosphorylation of glycogen synthase kinase-3β (GSK-3β) and total β-catenin protein expression. Furthermore, p38 and c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase (MAPK), and nuclear factor-κB (NF-κB) pathways were activated.ConclusionsSMF treatment enhanced osteoblastic and/or cementoblastic differentiation in osteoblasts, cementoblasts, and PDLCs. These findings provide a molecular basis for the beneficial osteogenic and/or cementogenic effect of SMFs, which could have potential in stimulating bone or cementum formation during bone regeneration and in patients with periodontal disease.

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“…In regard to the classic treatment protocol proposed by Branemark, three months of tissue healing after tooth removal, following three to six months of load-free interval after implant installationt are necessary for bone integration. Due to the great success rate of dental implants, this consuming period may lead to one year of reduced life quality, which can influence the judgment for dental implant rehabilitation (2) . Some researchers have attempted to shorten osteogeneration period by employing growth factors.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Platelet-Rich Plasma on Osseointegration Period of Dental Implants

Al-Gailani¹,

Abdul-Lateef²

2015

JBCD

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Background:The preparation of Platelet-rich plasma (PRP) is minimally invasive way, simple, low cost to obtain natural autologous growth factors and is now being widely used in different fields of medicine for its ability to increase the regeneration potential of tissue. The aim of this study was to investigate the effect of local application of autologous PRP gel on acceleration rate of osseointegration period by clinical assessment accomplished by determining the changes in implant stability during 3 months healing period using resonance frequency analysis (RFA). Materials and methods: A total of 28 dental implants were inserted in edentulous maxillae or mandibles of 13 patients using a split mouth design, i.e. each patient was received at least two dental implants at the same session, one implant was implanted in association with PRP which was placed locally in one site, to serve as PRP group, and the other implant was placed without PRP, to serve as a control group. Both groups were followed with repeated implant stability measurement by means of resonance frequency analysis at different time intervals (at the time of implant placement, 8 th week, and 12 th week postoperatively). Results: There was no obvious statistically significant difference in mean ISQ between PRP and control groups (P > 0.05) at baseline, 8 weeks, and 12 weeks postoperatively. Conclusions: Within the limitations of the present study, no appreciable clinical effect was observed to accelerate the rate of osseointegration of sandblasted acid-etched endosseous dental implants when using topical application of autologous PRP gel into the prepared drill holes.

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Effect of Static Magnetic Fields on the Osseointegration of Immediately Placed Implants

Abstract: SMFs caused more noticeable increase in implant stability and less bone loss during the initial weeks of healing.

Cited by 16 publications

References 31 publications

Static Magnetic Field (2–4 T) Improves Bone Microstructure and Mechanical Properties by Coordinating Osteoblast/Osteoclast Differentiation in Mice

Static Magnetic Field (2–4 T) Improves Bone Microstructure and Mechanical Properties by Coordinating Osteoblast/Osteoclast Differentiation in Mice

Static magnetic fields promote osteoblastic/cementoblastic differentiation in osteoblasts, cementoblasts, and periodontal ligament cells

The Effect of Platelet-Rich Plasma on Osseointegration Period of Dental Implants

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