Effect of Statins on Total Cholesterol Concentrations, Cardiovascular Morbidity, and All-Cause Mortality in Chronic Obstructive Pulmonary Disease: A Population-Based Cohort Study

The Role of Atorvastatin in the Treatment of Chronic Obstructive Pulmonary Disease With Elevated High Sensitive C-Reactive Protein

“…The effect on all-cause mortality is a gray area because it is possible that there are potential beneficial effects of statins on cardiovascular comorbidities as it is known that smoking is a causative factor in the majority of patients with COPD and in the (20) . The finding from the current study that statins not reduced mortality in patients with COPD were inconsistent with most of the included studies (21,22) . However, a large multi-centre randomized clinical trial showed that statins had no effect on COPD exacerbations, which was consistent with this finding (23) .…”

Statins reduce all-cause mortality in chronic obstructive pulmonary disease: a systematic review and meta-analysis of observational studies

“…Gestel reported two studies using the same cohort, one for all-cause mortality [11] and the other for cancer-related mortality [12]. Sheng reported two independent cohorts in an article, in which statins were prescribed for primary or secondary prevention [18]. Both all-cause and cardiovascular-related mortality were evaluated in each of the two cohorts [18].…”

“…Sheng reported two independent cohorts in an article, in which statins were prescribed for primary or secondary prevention [18]. Both all-cause and cardiovascular-related mortality were evaluated in each of the two cohorts [18]. All articles were full length except for Young’s report, which was published in the form of an abstract that evaluated the impact of statins for cause-specific mortality using data from the previously published study by Lawes [16,17].…”

Treatment of comorbid chronic obstructive pulmonary disease and cardiovascular disease

“…Обзоры В последние годы получена информация о проти вовоспалительном потенциале статинов при ХОБЛ. Их эффективность изучена в крупных международ ных исследованиях [32,33], по результатам которых установлено, что на фоне применении статинов те чение ХОБЛ становится более благоприятным -снижаются темп прогрессирования патологического процесса, количество госпитализаций, уровень сер дечно сосудистой и респираторной смертности та ких пациентов. Кроме этого, терапия статинами ассоциируется и со снижением легочного артериаль ного давления у пациентов с ХОБЛ, вероятно, через усиление локального синтеза оксида азота.…”