Effect of Stent Strut Interval on Neointima Formation After Venous Stenting in an Ovine Model

Evaluation of safety and performance of a new prototype self-expandable nitinol venous stent in an ovine model

“… 22 The inflammation and healing responses result in two major processes including vascular remodeling and neointimal hyperplasia. 23 , 24 , 25 In-stent stenosis is a major drawback owing to excessive intraluminal narrowing caused by neointimal growth or thrombosis. Therefore, efforts are made to optimize the outcome of venous stenting by modifying the structural design of the stent and improving the implantation procedure.…”

“… 26 Another study that investigated the venous response to stent implantation in a sheep model found that a larger stent strut interval led to less neointima formation and better long-term patency of the venous stents. 24 …”

“…A study in an ovine model investigating the neointima formation after venous stenting indicated that the longer bare areas and lower metallic burden of a stent implanted in the venous system facilitates faster and more complete endothelialization. 24 …”