Effect of subacute dosage of fluoride on male mice

Pillai, Krishna; Mathai, Annie; Deshmukh, P. B.

doi:10.1016/0378-4274(88)90125-7

Cited by 21 publications

(17 citation statements)

References 20 publications

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“…Shanthakumari, Srinivasalu, and Subramanian (2006) showed less WBC levels in F À -exposed subjects than controls. It was also found that in mice treated with sodium fluoride the WBC were increased (Pillai, Mathai, and Deshmukh 1989). From the results of the present study, it may be inferred that WBC counts are significantly altered by F À -induced toxicity.…”

Section: Resultsmentioning

confidence: 44%

“…Michael, Vinod, and Chinoy (1996) reported decreased Hb levels in F À exposed North Gujarat. Pillai, Mathai, and Deshmukh (1989) in rats treated with sodium fluoride also found significant reduction in Hb levels. Chinoy et al (1994) reported Hb levels among controls as 13.01 AE 2.65 and the levels in F À exposed subjects was 11.51 AE 0.13 g %.…”

Section: Resultsmentioning

confidence: 68%

“…RBC count of individuals consuming drinking water with the mean F À levels decreased compared to the control populations (Shanthakumari, Srinivasalu, and Subramanian 2006). In animal studies conducted in rats by Pillai, Mathai, and Deshmukh (1989) and in mice by Chinoy (1992) showed a significant reduction in RBC counts upon sodium fluoride treatment. In fact, this finding was conclusive as withdrawal of sodium fluoride treatment brought about a marked recovery in RBC in mice.…”

Section: Resultsmentioning

confidence: 96%

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Evaluation of hematological changes in population exposed to fluoride

Ravichandran¹,

Chattopadhyay

Gangopadhyay

et al. 2012

Toxicological & Environmental Chemistry

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Absorption of fluorine compounds produces chronic toxicity and the hematological changes appear earlier in blood than other organs. A study was undertaken to determine the status of hematological changes in the individual residing in fluoride-contaminated area. Two hundred and fifty nine and 233 subjects from the contaminated area and an unaffected area, respectively, were selected for hematological investigations. Total erythrocytes (red blood corpuscles (RBC)), total leucocytes (white blood corpuscles (WBC)), and hemoglobin (Hb) concentrations were determined in these populations. Results revealed that Hb values were significantly lower among all age groups in the exposed population compared to control subjects. There was a quantitative rise in WBC counts in study subjects compared to controls. The RBC counts showed reduction among exposed population.

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Section: Resultsmentioning

confidence: 44%

Section: Resultsmentioning

confidence: 68%

Section: Resultsmentioning

confidence: 96%

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Evaluation of hematological changes in population exposed to fluoride

Ravichandran¹,

Chattopadhyay

Gangopadhyay

et al. 2012

Toxicological & Environmental Chemistry

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“…Male Swiss mice administered orally 5.2 mg fluoride/kg body weight/day over 35 days were reported to have reduced erythrocyte and lymphocyte numbers in blood and increases in monocytes, eosinophils and basophils when compared to controls (Pillai et al, 1988).…”

Section: Short-term Studiesmentioning

confidence: 99%

Opinion of the Scientific Panel on Dietetic Products, Nutrition and Allergies (NDA) on a request from the Commission related to the Tolerable Upper Intake Level of Fluoride

Products¹

2005

EFSA Journal

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SUMMARYFluoride is not essential for human growth and development but is beneficial in the prevention of dental caries (tooth decay) when ingested in amounts of about 0.05 mg/kg body weight per day and when applied topically with dental products such as toothpaste. Dental enamel which contains fluoride is less likely to develop caries, because of greater resistance to ingested acids or to acids generated from ingested sugars by the oral bacteria. In addition, fluoride inhibits sugar metabolism by oral bacteria.Fluoride content of the body is not under physiological control. Absorbed fluoride is partly retained in bone and partly excreted, predominantly via the kidney. In infants retention in bone can be as high as 90% of the absorbed amount, whereas in adults retention is 50% or less. Fluoride is also incorporated into dental enamel during tooth formation.Excessive intake of fluoride during enamel maturation before tooth eruption from birth to eight years of age, when enamel formation is complete, can lead to reduced mineral content of enamel and to dental fluorosis of deciduous but predominantly of permanent teeth. The incidence and severity of dental fluorosis is dose-dependent. Mild dental fluorosis is not readily apparent and is associated with increased resistance to caries. The Panel considered moderate dental fluorosis, which is characterised by staining and minute pitting of teeth, to be an adverse effect. On the basis that the prevalence of moderate dental fluorosis of permanent teeth is less than 5% in populations ingesting 0.08-0.12 mg fluoride/kg body weight/day, the Panel considered that the upper level (UL) for fluoride is 0.1 mg fluoride/kg/day in children aged 1-8 years. This is equivalent to 1.5 and 2.5 mg fluoride per day in children aged 1-3 years and 4-8 years, respectively.Fluoride accretion in bone increases bone density but excessive long term intake reduces bone strength and increases risk of fracture and skeletal fluorosis (stiffness of joints, skeletal deformities). Studies with therapeutic oral administration of fluoride in amounts of 0.6 mg/kg body weight/day in postmenopausal women over several years increased the risk for nonvertebral bone fractures significantly. The Panel applied an uncertainty factor of 5 to derive an UL of 0.12 mg/kg body weight/day. This is equivalent to an UL of 5 mg/day in children aged 9-14 years and 7 mg/day for age 15 years and older, including pregnant and lactating women.The UL for fluoride applies to intake from water, beverages, foodstuffs, including fluoridated salt, dental health products and fluoride tablets for caries prevention.Children aged 1-8 years have fluoride intakes from food and water well below the UL provided the fluoride content of their drinking water is not higher than 1.0 mg/L. An increase

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“…1979; Kramer al.. 1978; Li et at.. 1987a Li et at.. , 1987bLi et at.. . 1987cLi et at.. , 1989Dunipace et al, 1989; Albanese, 1987;Pillai et al. 1988;Skare et al.…”

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Inorganic fluoride: Evaluation of risks to health from environmental exposure in Canada

Liteplo

Meek

Gomes

et al. 1994

Journal of Environmental Science and Health, Part C

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Inorganic fluoride is included on the List of Priority Substances to be assessed under the Canadian Environmental Protection Act.Available epidemiological data on the carcinogenicity of fluoride in human populations exposed in drinking water or in the occupational environment or in animal species exposed by ingestion are inconclusive. The estimated average daily intakes of inorganic fluoride for various age groups of the general population of Canada, are at least 20% less than the level ( : 200 μg/kg bw/day fluoride) at which adverse effects upon the skeleton, the end-point considered critical on the basis of available data, are anticipated to occur in humans.

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Effect of subacute dosage of fluoride on male mice

Cited by 21 publications

References 20 publications

Evaluation of hematological changes in population exposed to fluoride

Evaluation of hematological changes in population exposed to fluoride

Opinion of the Scientific Panel on Dietetic Products, Nutrition and Allergies (NDA) on a request from the Commission related to the Tolerable Upper Intake Level of Fluoride

Inorganic fluoride: Evaluation of risks to health from environmental exposure in Canada

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