Effect of Subthalamic Nucleus Deep Brain Stimulation on the Autonomic Nervous System in Parkinson’s Disease Patients Assessed by Spectral Analyses of R-R Interval Variability and Blood Pressure Variability

Sumi, Koichiro; Katayama, Yoichi; Otaka, Toshiharu; Obuchi, Toshiki; Kano, Toshikazu; Kobayashi, Kazuhiko; Oshima, Hideki; Fukaya, Chikashi; Yamamoto, Takamitsu; Ogawa, Yutaka; Iwasaki, Katsurô

doi:10.1159/000338090

Cited by 15 publications

(10 citation statements)

References 74 publications

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“…Deep brain stimulation employs chronically implanted electrodes in the brain to electrically stimulate neuronal networks (Albert et al., 2009), and has also been shown to increase CVC (Sumi et al., 2012).…”

Section: Main Textmentioning

confidence: 99%

A unifying conceptual framework of factors associated to cardiac vagal control

Laborde

Mosley

Mertgen

2018

Heliyon

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Cardiac vagal control (CVC) reflects the activity of the vagus nerve regulating cardiac functioning. CVC can be inferred via heart rate variability measurement, and it has been positively associated to a broad range of cognitive, emotional, social, and health outcomes. It could then be considered as an indicator for effective self-regulation, and given this role, one should understand the factors increasing and decreasing CVC. The aim of this paper is to review the broad range of factors influencing CVC, and to provide a unifying conceptual framework to integrate comprehensively those factors. The structure of the unifying conceptual framework is based on the theory of ecological rationality, while its functional aspects are based on the neurovisceral integration model. The structure of this framework distinguishes two broad areas of associations: person and environment, as this reflects adequately the role played by CVC regarding adaptation. The added value of this framework lies at different levels: theoretically, it allows integrating findings from a variety of scientific disciplines and refining the predictions of the neurovisceral integration model; methodologically, it helps identifying factors that increase and decrease CVC; and lastly at the applied level, it can play an important role for society regarding health policies and for the individual to empower one's flourishing.

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Section: Main Textmentioning

confidence: 99%

A unifying conceptual framework of factors associated to cardiac vagal control

Laborde

Mosley

Mertgen

2018

Heliyon

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“…76 Another controlled study including 28 PD patients proposed that the vagal component of the arterial-cardiac baroreflex improved postoperatively. 77 Dafsari et al . 23 suggested that STN DBS may have a long-term effect on cardiovascular symptoms, and opine that further studies are needed.…”

Section: Dbs Effect On the Autonomic Domainmentioning

confidence: 99%

The effect of deep brain stimulation on the non-motor symptoms of Parkinson’s disease: a critical review of the current evidence

Kurtis

Rajah

Delgado

et al. 2017

npj Parkinson's Disease

120

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The benefit of deep brain stimulation (DBS) in controlling the motor symptoms of Parkinson’s disease is well established, however, the impact on the non-motor symptoms (NMS) remains to be elucidated, although the growing investigative efforts are promising. This article reviews the reported data and considers the level of evidence available with regard to the effect of DBS on NMS total burden and on the cognitive, neuropsychiatric, sleep, pain, dysautonomic, and weight domains. Multiple case series suggest that DBS improves the burden of NMS by reducing prevalence, intensity, and non-motor fluctuations. There is level I evidence on the effect of DBS on cognition and mood. Slight cognitive decline has been reported in most class I studies, although the functional effect is probably minimal. Two randomized prospective studies reported no change in depression while improvement of anxiety has been reported by a class I trial. Prospective cohort studies point to improvement of hyperdopaminergic behaviors, such as impulse control disorders, while others report that hypodopaminergic states, like apathy, can appear after DBS. There is only class III evidence supporting the benefit of DBS on other NMS such as nocturnal sleep, pain, dysautonomia (urinary, gastrointestinal, cardiovascular, and sweating), and weight loss. Although preliminary results are promising, randomized prospectively controlled trials with NMS as primary end points are necessary to further explore the effect of DBS on these often invalidating symptoms and offer conclusions about efficacy.

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“…Several other publications also offer conflicting opinions on the cardiovascular effects of STN DBS [ 38 , 39 , 40 ]. Sumi et al [ 41 ] imply that the cardiovascular improvements seen with STN DBS are due not to the stimulation itself, but rather to an increased ability to exercise, thus improving overall cardiovascular health and lower extremity muscle strength. One explanation for the conflicting reports may be that the autonomic effects are not a direct result of the stimulation at all, but are rather the result of reduced need for pharmacotherapy to combat motor symptoms of PD [ 42 ].…”

Section: Sympathetic Autonomic Modulationmentioning

confidence: 99%

Effects of Deep Brain Stimulation on Autonomic Function

Basiago

Binder

2016

Brain Sciences

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Over the course of the development of deep brain stimulation (DBS) into a well-established therapy for Parkinson’s disease, essential tremor, and dystonia, its utility as a potential treatment for autonomic dysfunction has emerged. Dysfunction of autonomic processes is common in neurological diseases. Depending on the specific target in the brain, DBS has been shown to raise or lower blood pressure, normalize the baroreflex, to alter the caliber of bronchioles, and eliminate hyperhidrosis, all through modulation of the sympathetic nervous system. It has also been shown to improve cortical control of the bladder, directly induce or inhibit the micturition reflex, and to improve deglutition and gastric emptying. In this review, we will attempt to summarize the relevant available studies describing these effects of DBS on autonomic function, which vary greatly in character and magnitude with respect to stimulation target.

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Effect of Subthalamic Nucleus Deep Brain Stimulation on the Autonomic Nervous System in Parkinson’s Disease Patients Assessed by Spectral Analyses of R-R Interval Variability and Blood Pressure Variability

Cited by 15 publications

References 74 publications

A unifying conceptual framework of factors associated to cardiac vagal control

A unifying conceptual framework of factors associated to cardiac vagal control

The effect of deep brain stimulation on the non-motor symptoms of Parkinson’s disease: a critical review of the current evidence

Effects of Deep Brain Stimulation on Autonomic Function

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