Effect of surface-modified superparamagnetic iron oxide nanoparticles (SPIONS) on mast cell infiltration: An acute in vivo study

Sabareeswaran, A; Ansar, Ereath Beeran; Varma, Parimanathu Rama Varma Harikrishna; Mohanan, P.V.; Kumary, T. V.

doi:10.1016/j.nano.2016.02.018

Cited by 33 publications

(8 citation statements)

References 58 publications

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“…Studying adverse immune responses following ENM exposure has become increasingly important with emergence of nanomedicines, considering drug allergies are a limiting factor for patient compliance and could often lead to drug removal from the market 16 . Mast cells, involved in the innate and adaptive immune responses functioning in host defense, have been implicated as an early effector cell in response to ENM exposures 17 18 19 20 21 22 23 24 25 26 27 . They play a predominant role in the development of allergic inflammation, resulting in diseases such as allergies, asthma, and anaphylaxis.…”

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confidence: 99%

Contribution of engineered nanomaterials physicochemical properties to mast cell degranulation

Johnson

Mendoza

Raghavendra

et al. 2017

Sci Rep

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The rapid development of engineered nanomaterials (ENMs) has grown dramatically in the last decade, with increased use in consumer products, industrial materials, and nanomedicines. However, due to increased manufacturing, there is concern that human and environmental exposures may lead to adverse immune outcomes. Mast cells, central to the innate immune response, are one of the earliest sensors of environmental insult and have been shown to play a role in ENM-mediated immune responses. Our laboratory previously determined that mast cells are activated via a non-FcεRI mediated response following silver nanoparticle (Ag NP) exposure, which was dependent upon key physicochemical properties. Using bone marrow-derived mast cells (BMMCs), we tested the hypothesis that ENM physicochemical properties influence mast cell degranulation. Exposure to 13 physicochemically distinct ENMs caused a range of mast degranulation responses, with smaller sized Ag NPs (5 nm and 20 nm) causing the most dramatic response. Mast cell responses were dependent on ENMs physicochemical properties such as size, apparent surface area, and zeta potential. Surprisingly, minimal ENM cellular association by mast cells was not correlated with mast cell degranulation. This study suggests that a subset of ENMs may elicit an allergic response and contribute to the exacerbation of allergic diseases.

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confidence: 99%

Contribution of engineered nanomaterials physicochemical properties to mast cell degranulation

Johnson

Mendoza

Raghavendra

et al. 2017

Sci Rep

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“…The potential toxicity of SPIONs is highly dependent on the size of the NPs, exposure time, type of coating, and type of tissue 27. The present study does not provide data on the toxicity of quercetin-loaded SPIONs, but previous reports have shown that quercetin–Fe 3 O 4 NPs have no remarkable toxic effects on liver, kidney, or heart samples of animals 28,39,40. Additionally, no cell toxicity was found in brain tissue of rats treated with Qur-SPIONs 27…”

Section: Discussionmentioning

confidence: 69%

Fabrication and evaluation of novel quercetin-conjugated Fe3O4–β-cyclodextrin nanoparticles for potential use in epilepsy disorder

Hashemian¹,

Ghasemi-Kasman²,

Ghasemi³

et al. 2019

IJN

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Background Despite the numerous pharmacological activities of quercetin, its biomedical application has been hampered, because of poor water solubility and low oral bioavailability. In the present study, we fabricated a novel form of quercetin-conjugated Fe 3 O 4 –β-cyclodextrin (βCD) nanoparticles (NPs), and the effect of these prepared NPs was evaluated in a chronic model of epilepsy. Methods Quercetin-loaded NPs were prepared using an iron oxide core coated with βCD and pluronic F68 polymer. The chronic model of epilepsy was developed by intraperitoneal injection of pentylenetetrazole (PTZ) at dose of 36.5 mg/kg every second day. Quercetin or its nanoformulation at doses of 25 or 50 mg/kg were administered intraperitoneally 10 days before PTZ injections and their applications continued 1 hour before each PTZ injection. Immunostaining was performed to evaluate the neuronal density and astrocyte activation of hippocampi. Results Our data showed successful fabrication of quercetin onto Fe 3 O 4 –βCD NPs. In comparison to free quercetin, quercetin NPs markedly reduced seizure behavior, neuronal loss, and astrocyte activation in a PTZ-induced kindling model. Conclusion Overall, quercetin–Fe 3 O 4 –βCD NPs might be regarded as an ideal therapeutic approach in epilepsy disorder.

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“…Enhanced production of proinflammatory cytokines by mast cells occurs in mice treated with cerium oxide NPs (57). Particular types of modified superparamagnetic iron oxide or silica NPs also stimulate mast cell infiltration into tissues, such as the lungs, heart, and liver, through NP-induced tissue damage (58,59). In this case, the observed effects were not a direct effect on mast cells but an inflammatory response to tissue damage caused by the NPs.…”

Section: The Impact Of Inorganic Nps On Mast Cell Functionmentioning

confidence: 99%

The Possible Uses and Challenges of Nanomaterials in Mast Cell Research

Duguay

Lü

Arizmendi

et al. 2020

The Journal of Immunology

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Mast cells are tissue-resident immune cells that are involved in inflammation and fibrosis but also serve beneficial roles, including tissue maintenance, angiogenesis, pathogen clearance, and immunoregulation. Their multifaceted response and the ability of their mediators to target multiple organs and tissues means that mast cells play important roles in numerous conditions, including asthma, atopic dermatitis, drug sensitivities, ischemic heart disease, Alzheimer disease, arthritis, irritable bowel syndrome, infections (parasites, bacteria and viruses), and cancer. As a result, mast cells have become an important target for drug discovery and diagnostic research. Recent work has focused on applying novel nanotechnologies to explore cell biology. In this brief review, we will highlight the use of nanomaterials to modify mast cell functions and will discuss the potential of these technologies as research tools for understanding mast cell biology.

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Effect of surface-modified superparamagnetic iron oxide nanoparticles (SPIONS) on mast cell infiltration: An acute in vivo study

Cited by 33 publications

References 58 publications

Contribution of engineered nanomaterials physicochemical properties to mast cell degranulation

Contribution of engineered nanomaterials physicochemical properties to mast cell degranulation

<p>Fabrication and evaluation of novel quercetin-conjugated Fe<sub>3</sub>O<sub>4</sub>–β-cyclodextrin nanoparticles for potential use in epilepsy disorder</p>

The Possible Uses and Challenges of Nanomaterials in Mast Cell Research

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