“…Although apical PSM do not reflect higher treatment failure risks, it still is the most frequent site of PSM, as found in the current study as well as others. These findings should discourage urologists to stand reluctant to remove excess tissue in the apical region in order to preserve surrounding tissues including the sphincteric complex [18,19]. …”
Introduction: Additional insight in the occurrence and number of positive surgical margins (PSM) and the potential consequences is needed, since earlier studies show divergent results. This study aims at investigating the effect of the presence and number of PSM on oncological outcomes. Methods: Retrospective population-based cohort study including 648 consecutive prostate cancer patients who underwent RP in the Southern Netherlands in 2006-2008. The effect of PSM on risk of treatment failure, defined by either biochemical recurrence or necessity of any additional therapy (Cox regression), was evaluated. Results: PSM were observed in 39%; 11% had multiple PSM. Treatment failure was observed in 26% of all patients. Multivariably, the presence (hazard ratio 2.5) and number of PSM (hazard ratios: single 2.3; multiple 3.1) were independently associated with higher treatment failure rates, unlike location of PSM. Conclusions: Treatment failure rates are high among patients with PSM, especially in those with multiple PSM. This needs to be taken into account when decisions are made on the applicability of the adjuvant and salvage therapy.
“…Although apical PSM do not reflect higher treatment failure risks, it still is the most frequent site of PSM, as found in the current study as well as others. These findings should discourage urologists to stand reluctant to remove excess tissue in the apical region in order to preserve surrounding tissues including the sphincteric complex [18,19]. …”
Introduction: Additional insight in the occurrence and number of positive surgical margins (PSM) and the potential consequences is needed, since earlier studies show divergent results. This study aims at investigating the effect of the presence and number of PSM on oncological outcomes. Methods: Retrospective population-based cohort study including 648 consecutive prostate cancer patients who underwent RP in the Southern Netherlands in 2006-2008. The effect of PSM on risk of treatment failure, defined by either biochemical recurrence or necessity of any additional therapy (Cox regression), was evaluated. Results: PSM were observed in 39%; 11% had multiple PSM. Treatment failure was observed in 26% of all patients. Multivariably, the presence (hazard ratio 2.5) and number of PSM (hazard ratios: single 2.3; multiple 3.1) were independently associated with higher treatment failure rates, unlike location of PSM. Conclusions: Treatment failure rates are high among patients with PSM, especially in those with multiple PSM. This needs to be taken into account when decisions are made on the applicability of the adjuvant and salvage therapy.
“…The tumor volume was calculated by multiplying the tumor surface area by the thickness of the slice (0.4 cm of whole-mount slice or 0.2 cm of small slice) and then multiplying by a correction factor of 1.12 [ 9 ]. A specimen was defined as surgical margin positive if tumor cell invasion was microscopically observed on the ink-labeled prostate sections [ 10 ]. Fig.…”
BackgroundProstate biopsy is the most common method for the diagnosis of prostate cancer and the basis for further treatment. Confirmation using radical prostatectomy specimens is the most reliable method for verifying the accuracy of template-guided transperineal prostate biopsy. The study aimed to reveal the spatial distribution of prostate cancer in template-guided transperineal saturation biopsy and radical prostatectomy specimens.MethodsBetween December 2012 to December 2016, 171 patients were diagnosed with prostate cancer via template-guided transperineal prostate biopsy and subsequently underwent laparoscopic radical prostatectomy. The spatial distributions of prostate cancer were analyzed and the consistency of the tumor distribution between biopsy and radical prostatectomy specimens were compared.ResultsThe positive rate of biopsy in the apex region was significantly higher than that of the other biopsy regions (43% vs 28%, P < 0.01). In radical prostatectomy specimens, the positive rate was highest at the region 0.9–1.3 cm above the apex, and it had a tendency to decrease towards the base. There was a significant difference in the positive rate between the cephalic and caudal half of the prostate (68% vs 99%, P < 0.01). There were no significant differences between the anterior and posterior zones for either biopsy or radical prostatectomy specimens.ConclusionThe tumor spatial distribution generated by template-guided transperineal prostate biopsy was consistent with that of radical prostatectomy specimens in general. The positive rate was consistent between anterior and posterior zones. The caudal half of the prostate, especially the vicinity of the apex, was the frequently occurred site of the tumor.
“…When views about the illness representations subdimension were analyzed, it was found that personal control subdimension had the highest mean score. When the relevant literature is analyzed, it is also found that although personal control scores are generally low in cancer patients, there are studies where it is high . In Turkish society, both emotional and physical support to the patient increases during illness.…”
Section: Discussionmentioning
confidence: 99%
“…When the relevant literature is analyzed, it is also found that although personal control scores are generally low in cancer patients, 14,[18][19][20][21] there are studies where it is high. 5,22,23 In Turkish society, both emotional and physical support to the patient increases during illness. The traditional family structure still thrives in the area where the survey was conducted.…”
Nurses should evaluate the anxiety levels of the cancer patients in every stage and should educate the patients and their relatives on coping with anxiety. Appropriate treatment and care depending on the illness perception of the cancer patients should be planned by nurses.
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