Effect of symptomatic gastroesophageal reflux disease on quality of life of patients with chronic liver disease

Suzuki, Kazutomo; Suzuki, Kazuyoshi; Koizumi, Kazuhito; Takada, Hiroshi; Nishiki, Ryoichi; Ichimura, Hiroki; Oka, Shigeki; Kuwayama, Hajime

doi:10.1111/j.1872-034x.2007.00275.x

Cited by 12 publications

(14 citation statements)

References 12 publications

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“…Previous studies have reported lower QOL in patients with cirrhosis compared with normal controls and liver disease patients without cirrhosis. However, most of those studies were limited by small sample sizes,19, 24, 25 use of single‐center samples,13, 26–30 disease‐specific measures,31, 32 or the inclusion of univariable analysis only 9, 26–28, 33. Studies that have used surrogate measures of cirrhosis, such as presence of splenomegaly or patient self‐report of cirrhosis, suggested that cirrhosis may be independently associated with lower QOL, in a variety of other liver diseases 34, 35.…”

Section: Discussionmentioning

confidence: 99%

Quality of life in adults with nonalcoholic fatty liver disease

David¹,

Kowdley²,

Ünalp³

et al. 2009

Hepatology

142

165

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Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the UnitedStates. The association between NAFLD and quality of life (QOL) remains unclear. These data are important to estimate the burden of illness in NAFLD. The aim was to report QOL scores of adults with NAFLD and examine the association between NAFLD severity and QOL. QOL data were collected from adults with NAFLD enrolled in the Nonalcoholic Steatohepatitis Clinical Research Network using the Short Form 36 (SF-36) survey, and scores were compared with normative U.S. population scores. Liver biopsy histology was reviewed by a central pathology committee. A total of 713 subjects with NAFLD (male ‫؍‬ 269, female ‫؍‬ 444) were included. Mean age of subjects was 48.3 years; 61% had definite nonalcoholic steatohepatitis (NASH), and 28% had bridging fibrosis or cirrhosis. Diabetes was present in 27% of subjects. Subjects with NAFLD had worse physical (mean, 45.2) and mental health scores (mean, 47.6) compared with the U.S. population with (mean, 50) and without (physical, 55.8; mental, 52.5) chronic illness. Subjects with NASH reported lower physical health compared with subjects with fatty liver disease without NASH (44.5 versus 47.1, P ‫؍‬ 0.02). Subjects with cirrhosis had significantly (P < 0.001) poorer physical health scores (38.4) than subjects with no (47.6), mild (46.2), moderate (44.6), or bridging fibrosis (44.6). Cirrhosis was associated with poorer physical health after adjusting for potential confounders. Mental health scores did not differ between participants with and without NASH or by degree of fibrosis. Conclusion: Adults with NAFLD have a significant decrement in QOL. Treatment of NAFLD should incorporate strategies to improve QOL, especially physical health. (HEPATOLOGY 2009;49:1904-1912

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Section: Discussionmentioning

confidence: 99%

Quality of life in adults with nonalcoholic fatty liver disease

David¹,

Kowdley²,

Ünalp³

et al. 2009

Hepatology

142

165

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“…They are the most abundant of the proteins in blood plasma, accounting for about 60% of the total protein corresponding to a concentration of 42 g L À 1 and provide about 80% of the osmotic pressure of blood [1]. Serum albumins have been used as a model protein for many and diverse biophysical, biochemical, and physicochemical studies [2][3][4]. As a kind of serum albumin, bovine serum albumin (BSA) has the advantages of medical importance, low cost, ready availability, and unusual ligand-binding properties.…”

Section: Introductionmentioning

confidence: 99%

Study on the interaction of La3+ with bovine serum albumin at molecular level

Yuan

Shen

Liu

et al. 2011

Journal of Luminescence

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“…Patients with chronic liver disease patients, especially patients with portal hypertension and liver cirrhosis, have clinical manifestations, such as esophageal varices, ascites, and edema. Some studies have been conducted regarding the role of esophageal varices in the development of esophageal motor disorders and abnormal gastroesophageal reflux in these patients [7,8]. Ascites could be a factor promoting gastroesophageal reflux and it has been questioned whether or not reflux would favor the rupture of varices [9,10].…”

Section: Introductionmentioning

confidence: 99%

High prevalence of reflux esophagitis among upper endoscopies in Chinese patients with chronic liver diseases

Zhang

Wei

et al. 2010

BMC Gastroenterol

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BackgroundReflux esophagitis (RE) is increasing in prevalence in China. There are very few studies on the prevalence and factors related to RE in patients with chronic liver diseases. The aims of this study were to determine the prevalence of RE by endoscopy in patients with chronic liver diseases and the possible related predictors of RE.MethodsA total of 1,280 patients with chronic liver disease and 29 patients with acute hepatitis A or E were prospectively evaluated. There were 879 and 401 patients with liver cirrhosis or chronic hepatitis, respectively. RE was classified by endoscopy according to the Los Angeles classification scheme.ResultsRE was diagnosed in 36.4% (469/1280) of the chronic liver disease patients, which was significantly higher than in the acute hepatitis patients (10.3% [3/29], P < 0.001). RE accounted for 43.0%, 9.7%, and 60.2% of patients with liver cirrhosis, chronic hepatitis(mild and medium), and liver failure, respectively. A high prevalence of RE existed in patients with liver failure and/or Child B and C liver cirrhosis, with typical symptoms of RE in 21.3% of the patients (100/469). There was a significant relationship between gender, age, ascites, and RE.ConclusionsThe high prevalence of RE among upper endoscopies of patients with severe chronic liver disease was demonstrated. Asymptomatic RE was more common in cirrhotic and liver failure patients. The role of RE in variceal bleeding, however, needs to be demonstrated.

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Effect of symptomatic gastroesophageal reflux disease on quality of life of patients with chronic liver disease

Abstract: The QOL of chronic liver disease patients with symptomatic GERD was impaired.

Cited by 12 publications

References 12 publications

Quality of life in adults with nonalcoholic fatty liver disease

Quality of life in adults with nonalcoholic fatty liver disease

Study on the interaction of La3+ with bovine serum albumin at molecular level

High prevalence of reflux esophagitis among upper endoscopies in Chinese patients with chronic liver diseases

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