Effect of Synthetic Thioctic or Alpha Lipoic Acid on the Voluntary Alcohol Intake of Rats

Genetic Selection for Voluntary Alcohol Consumption in the Albino Rat

“…The purpose of this slow selection was to secure the maximum possible difference between strains. Inasmuch as previous work (1)(2)(3)(4)(5) warranted the assumption that heritability is rather low, the breeding animals were chosen in the manner proposed by Falconer (7), by selection within the family so that about 25 percent of the animals were used for continued breeding.…”

“…For the most part, they represent single amino acid substitutions which usually have no measurable effect on the physiological property of the hemoglobin molecule as a respiratory pigment. Recently, abnormal hemoglobins with a functional abnormality consisting of increased oxygen affinity have been reported (1,2). In heterozygotes for these abnormal hemoglobins, lower volumes of oxygen per red cell are released to the tissue.…”

Alpha-Lipoic Acid Reduces Ethanol Self-Administration in Rats

“…Moreover, acute administration of ALA enhances glutathione peroxidase activity in different regions of the rat brain and decreases the concentration of ROS, especially H 2 O 2 (Bilska et al., ). Although with different objectives, Mardones in the early 1950s reported that ALA induced a decrease on the voluntary EtOH intake of rats (Mardones et al., ). On the other hand, Ledesma and Aragon () have demonstrated that a decrease in cerebral H 2 O 2 production by ALA administration inhibits EtOH‐stimulated locomotion suggesting that the brain catalase‐H 2 O 2 system, and by implication centrally formed ACD, plays a role in the effects of EtOH.…”