Effect of systemic corticosteroids on serum apoptotic markers and quality of life in patients with asthma

Bhargava, Shashikant; Prakash, Anupam; Rehan, Harmeet Singh; Gupta, Lalit

doi:10.2500/aap.2015.36.3834

Cited by 10 publications

(7 citation statements)

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“…Systemic corticosteroids seem to significantly improve quality of life [ 22 ], however, only seven of our patients received systemic corticosteroids and although on average their QoL was higher, this difference was statistically not significant. Schatz et al [ 7 ] reported asthma-specific QoL during pregnancy is related to asthma exacerbations and to perinatal outcomes.…”

Section: Discussionmentioning

confidence: 88%

Quality of life and asthma control in pregnant women with asthma

et al. 2021

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Background Asthma is the most commonly occurring respiratory illness during pregnancy. Associations with complications of pregnancy and adverse perinatal outcome have been established. However, little is known about quality of life (QoL) in pregnant women with asthma and how it relates to asthma control particularly for Iran. Objective To determine the relationship between asthma related QoL and asthma control and severity. Methods We conducted a prospective study in pregnant women with asthma. We used the Asthma Control Questionnaire and the Asthma Quality of Life Questionnaire (AQLQ) and the guidelines of the Global Initiative for Asthma for assessment of asthma severity. Results Among 1603 pregnant women, 34 were diagnosed with asthma. Of these 13 had intermittent, 10 mild, 8 moderate and 3 severe persistent asthma. There was a significant decrease of QoL with poorer asthma control (p = 0.014). This decline could be due to limitations of activity in those with poorer asthma control, which is underlined by the significant decline of QoL with increasing asthma severity (p = 0.024). Conclusion Although the majority of pregnant women with asthma had a favorable score in AQLQ, reduced QoL was related to increased asthma severity and poor asthma control. This underlines the importance of controlling asthma during pregnancy not only for the prevention of adverse pregnancy outcomes but also for the preservation of QoL.

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Section: Discussionmentioning

confidence: 88%

Quality of life and asthma control in pregnant women with asthma

et al. 2021

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“…These comorbidities are also linked with the use of drugs that were identified in our study as putative risks like amlodipine and methylprednisolone. Researchers had already proved that the use of both, calcium channel blockers and corticosteroids in the treatment of chronic disease, in fact, increased patients' quality of life [35][36][37] . Therefore, it seems that the quality of life in the mechanically ventilated CAP patients is influenced rather by the complex milieu of numerous subtleacting, highly interconnected, intrinsic and acquired factors than by the profound effects of leading causes.…”

Section: Discussionmentioning

confidence: 99%

Quality of life of the mechanically ventilated patients with community-acquired pneumonia

et al. 2018

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Background/Aim. Patients with pneumonia who require mechanical ventilation (MV) are associated with several poor outcomes such as prolonged hospitalization, higher rate of mortality and increased spread of antibioticsresistant pathogens. MV in patients with communityacquired pneumonia (CAP) could cause development of psychological symptoms, often neglected in the Intensive Care Units (ICU) as well as decreased quality of life after the withdrawal of the MV. The aim of the study was to evaluate the quality of life in patients with CAPs treated with MV in ICU. Methods. The study was designed as a cohort study of hospital-treated patients with CAP with prospective data collection. The quality of life was defined as the primary outcome, while the use of MV was assumed as the primary prognostic factor that adversely affected the outcome. The patients were recruited from the population of patients with CAPs who were hospitalized at the ICU, Clinical Center Kragujevac, Serbia, from January 2013 to January 2014. The experimental group consisted of patients who were on MV while the control group included patients who were treated for CPAs in the ICU, but were not subjected to MV. The quality of life was assessed by using patient-rated Euro Quality of Life (EuroQoL) Group-EQ-5D index. The calculation of the total EQ-5D-5L score values was performed by using the predefined, validated mapping key according to response combinations. Statistical analysis was performed by using ?2 test, Student's t-test, univariate and multivariate logistic regression analyses. Results. The patients with MV had worse EQ5D-5L values in comparison to the control group for all 5 domains. Mobility, self-care and usual activities were negatively affected during the whole follow-up period. Pain or discomfort and anxiety or depression differed significantly between the study group and the control group at days 7 and 30. Conclusion. Patients with MV tend to have poorer quality of life, especially in 3 domains. The main reasons are the presence of chronic comorbidities in the population that require MV. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 175007]

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“…Further, Bhargava et al (2015) evaluated the effect of systemic corticosteroids on a new serum apoptotic markers, Survivin and M30 apoptosense in asthmatic patients. The study was conducted in 60 patients with acute exacerbation of bronchial asthma and treated with systemic corticosteroids.…”

Section: Newer Biomarkers In Respiratory Disordersmentioning

confidence: 99%

Status of Research in Respiratory Pharmacology in India during the last Five Years (2012-2017)

Gulati¹,

Rai²,

Ray³

2018

Proceedings of the Indian National Science Academy

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Research in the area of respiratory pharmacology and toxicologyis very exciting and vital for the development of new drugs with more efficacy and safety. Several medicinal plants from the Ayurveda and Unani systems of medicine are being evaluated for their efficacy and safety by using modern medical techniques;with an aim to bring them to the mainstream of the health care system. Effects of yogic intervention on pulmonary functions, cellular and molecular markers and quality of life in patients of bronchial asthma are also being assessed. Further, a lot of work is also going on novel aspects of immunotherapy and nanomedicine in the management of respiratory disorders. This review also highlights the relevance and pharmacoeconomic impact of nutraceuticals in prevention and treatment of respiratory diseases. Many clinical trials are being conducted to compare the efficacy and safety of already marketed individual drugs and combination therapy. Pharmacovigilance studies are being conducted to monitor the ADRs during pharmacotherapy of respiratory diseases, assess the causal relationship and find ways to prevent the ADRs to rationalize the therapy. However, more translational research is needed to bring scientific advances and knowledge into clinical practice; and there is a great need to find effective ways for collaboration between various research disciplines. There should be a focus on earlier and more specific diagnosis of respiratory diseases as well as better targeted and personalized treatments which may save cost, reduce adverse effects and improve disease outcomes and quality of life.

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Effect of systemic corticosteroids on serum apoptotic markers and quality of life in patients with asthma

Cited by 10 publications

References 0 publications

Quality of life and asthma control in pregnant women with asthma

Quality of life and asthma control in pregnant women with asthma

Quality of life of the mechanically ventilated patients with community-acquired pneumonia

Status of Research in Respiratory Pharmacology in India during the last Five Years (2012-2017)

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