Effect of taxifolin on development of retinopathy in alloxan-induced diabetic rats

Ahiskali, Ibrahim; Pinar, Can Lokman; Kiki, Murat; Mammadov, Renad; Bilgin, Asli Ozbek; Hacımüftüoğlu, Ahmet; Çankaya, Murat; Çimen, Ferda Keskin; Altuner, Durdu

doi:10.1080/15569527.2019.1588289

Cited by 29 publications

(17 citation statements)

References 29 publications

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“…There are no studies in the literature on the effect of taxifolin on LPO in cochlear tissue. However, recent studies have shown that taxifolin inhibits MDA increase in blood serum and heart tissue (20,21). This information obtained from the literature shows that previous studies support the results of our biochemical and histopathological experiments.…”

Section: Histopathological Resultssupporting

confidence: 92%

The Effect of Taxifolin on Cisplatin Induced Oxidative Cochlear Damage in Rats: Biochemical and Histopathological Examination

Erhan¹,

Bayram²,

Çimen³

et al. 2019

Acta Poloniae Pharmaceutica - Drug Research

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Ototoxicity of cisplatin is one of the major dose-limiting side effects. Cisplatin-dependent ototoxicity is known to be associated with reactive oxygen species. Protective effect of taxifolin, being a flavanone found in onions, milk thistle, French maritime, and Douglas fir bark, against cisplatin-associated ototoxicity will be examined in this study. There are no studies in the literature examining the protective effect of taxifolin against cisplatin-induced ototoxicity. 50 mg/kg taxifolin was orally administered to TXC group rats (n-6), and distilled water was orally administered as a solvent to CG (n-6) and HG (n-6) groups. One hour later, 5 mg/kg cisplatin was administered intraperitoneally (i.p) to TXC and CG groups. This procedure was repeated once a day for 7 days. At the end of this period, all animals were sacrificed by high-dose anesthesia (50 mg/kg thiopental sodium) and biochemical and histopathological examinations were performed on the dissected cochlear tissue. Our biochemical test results showed that oxidant parameters were significantly increased whereas antioxidant parameters were significantly decreased in the cisplatin group (CG) compared to taxifolin (TXC) and healthy (HG) groups (p < 0.0001 for both parameters). Histopathological results showed that severe cochlear vestibular membrane degeneration, dilated conjunctival blood vessels, edema and destruction developed in the cisplatin group. However, no pathological findings were found in the taxifolin-treated group except for mild degeneration and edema. This information suggests that taxifolin may be useful in the treatment of cisplatinassociated oxidative cochlear damage.

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Section: Histopathological Resultssupporting

confidence: 92%

The Effect of Taxifolin on Cisplatin Induced Oxidative Cochlear Damage in Rats: Biochemical and Histopathological Examination

Erhan¹,

Bayram²,

Çimen³

et al. 2019

Acta Poloniae Pharmaceutica - Drug Research

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“…Studies have shown that the secretion of inflammation-related cytokines (TNF- α , IL-6, etc.) in human retinal endothelial cells (HRECs) in high glucose environment increases [ 42 ], suggesting that TNF- α may be involved in the inflammatory response of retinal endothelial cells in high glucose environment, thus promoting the related clinical manifestations of DR. Studies have shown that after treatment, the expression level of TNF- α in DR model decreased [ 43 – 45 ]. This further confirms the important role of TNF- α in the pathological changes of DR.…”

Section: Discussionmentioning

confidence: 99%

Exploring the Mechanism of Action Compound‐Xueshuantong Capsule in Diabetic Retinopathy Treatment Based on Network Pharmacology

Zheng

2020

Evidence-Based Complementary and Alternative Medicine

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Aim of the Study. To study the mechanism of Compound-Xueshuantong Capsule in diabetic retinopathy treatment based on network pharmacology. Materials and Methods. The components with oral bioavailability ≥30% and drug similarity ≥0.18 were screened by the Traditional Chinese Medicine System Pharmacology Database and Analysis Platform (TCMSP), and the effective grouping of Compound-Xueshuantong Capsule was obtained. At the same time, the targets of each drug active component in the Compound-Xueshuantong Capsule were obtained by searching the TCMSP. The effective components and targets of the Compound-Xueshuantong Capsule were annotated by the UniProt database, and the disease treatment targets were searched by the GeneCards database. The disease treatment target is intersected with the drug target and the Wayne diagram is drawn by VennDiagram. The active ingredient targets of the intersection and Compound-Xueshuantong Capsule were inputted into Cytoscape 3.7.2 software to construct the active ingredient-target-disease interaction network. The above targets were inputted into the String database for protein-protein interaction network prediction. Finally, by using the DAVID database, GO and KEGG enrichment analysis was carried out to reveal the potential signal pathway of the Compound-Xueshuantong Capsule in diabetic retinopathy treatment. Results. 93 active components of the Compound-Xueshuantong Capsule and 92 targets for treating diabetic retinopathy were screened. The main active components of the Compound-Xueshuantong Capsule in treating diabetic retinopathy were quercetin, luteolin, kaempferol, beta-sitosterol, isorhamnetin, and tanshinone IIa. The effect of the Compound-Xueshuantong Capsule on diabetic retinopathy may be related to IL6, EFGR, CASP3, and VEGFA. In addition, the treatment of diabetic retinopathy mainly involves in the regulation of nuclear receptors and transcription factors in vivo. The target of the Compound-Xueshuantong Capsule in diabetic retinopathy treatment is significantly enriched in the AGE-RAGE signal pathway, TNF signal pathway, HIF-1 signal pathway, and VEGF signal pathway in diabetic complications. Conclusion. Compound-Xueshuantong Capsule can treat diabetic retinopathy through multitarget, multipathway, and multipathway regulation of the biomolecular network. The potential biological mechanism of the Compound-Xueshuantong Capsule in diabetic retinopathy treatment may be related to the AGE-RAGE signal pathway, TNF signal pathway, HIF-1 signal pathway, and VEGF signal pathway in diabetic complications, but these findings still need to be confirmed by further clinical research.

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“…There is an increasing body of evidence about the role of antioxidants in the control of diabetic retinopathy in animal models ( Table 2 ) [ 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , …”

Section: Animal Studiesmentioning

confidence: 99%

“…Taxifolin is useful to prevent diabetic retinal damage. It can normalize the Il-6, TNF, IL1 and tGSH levels in blood serum [ 98 ]. Other flavonoids such as hesperetine [ 75 ] have been studied, obtaining promising results.…”

Section: Animal Studiesmentioning

confidence: 99%

Update on the Effects of Antioxidants on Diabetic Retinopathy: In Vitro Experiments, Animal Studies and Clinical Trials

et al. 2020

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Current therapies for diabetic retinopathy (DR) incorporate blood glucose and blood pressure control, vitrectomy, photocoagulation, and intravitreal injections of anti-vascular endothelial growth factors or corticosteroids. Nonetheless, these techniques have not been demonstrated to completely stop the evolution of this disorder. The pathophysiology of DR is not fully known, but there is more and more evidence indicating that oxidative stress is an important mechanism in the progression of DR. In this sense, antioxidants have been suggested as a possible therapy to reduce the complications of DR. In this review we aim to assemble updated information in relation to in vitro experiments, animal studies and clinical trials dealing with the effect of the antioxidants on DR.

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Effect of taxifolin on development of retinopathy in alloxan-induced diabetic rats

Cited by 29 publications

References 29 publications

The Effect of Taxifolin on Cisplatin Induced Oxidative Cochlear Damage in Rats: Biochemical and Histopathological Examination

The Effect of Taxifolin on Cisplatin Induced Oxidative Cochlear Damage in Rats: Biochemical and Histopathological Examination

Exploring the Mechanism of Action Compound‐Xueshuantong Capsule in Diabetic Retinopathy Treatment Based on Network Pharmacology

Update on the Effects of Antioxidants on Diabetic Retinopathy: In Vitro Experiments, Animal Studies and Clinical Trials

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