Effect of tea catechins on erythrocyte Ca<sup>++</sup>-pump in type 2 diabetes mellitus

Rizvi, Syed Ibrahim; Zaid, Mohd Abu

doi:10.1080/13880200902822588

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…It is known that the intracellular calcium concentration is increased in most tissues in subjects with diabetes and that altered intracellular calcium metabolism seems to result from a common, underlying abnormality linking metabolic, cardiovascular, ocular and neural manifestations in the diabetic disease process (26).…”

Section: Discussionmentioning

confidence: 99%

Effect of levosimendan on erythrocyte deformability during myocardial ischaemia-reperfusion injury

Arslan¹,

Fm²,

Alkan³

et al. 2015

BLL

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Diabetes mellitus (DM) is a chronic metabolic disorder accompanied by an increase in oxidative stress. Ischaemia-reperfusion (IR) injury is a cascade of events initiated by tissue ischaemia. The cellular damage produced by reperfusion leads to an active inflammatory response. Erythrocyte deformability and plasma viscosity are of crucial importance for the perfusion of tissues and organs. The aim of this study was to evaluate the effect of levosimendan on erythrocyte deformability during IR myocardial injury in diabetic rats. Methods: Twenty-four Wistar albino rats were included in the study after streptozocin (55 mg/kg) treatment for 4 weeks to observe the existence of diabetes. The animals were randomly assigned to one of four experimental groups. In Group C and DC (sham-control group), the coronary artery was not occluded or reperfused in the control rats. Myocardial IR was induced by ligation of the left anterior descending coronary artery for 30 min, followed by 2 h of reperfusion in the diabetes-IR (DIR) and diabetes-IR-levosimendan (DIRL) group. Deformability measurements were performed in erythrocyte suspensions containing Htc 5 % in a phosphate-buffered saline (PBS) buffer. Results: The deformability index was signifi cantly increased in the diabetic rats. It was similar in Group DC and DIRL It was signifi cantly increased in the DIR group compared to Group C, DIRL and DC. The relative resistance was increased in the IR models. Conclusion: Erythrocyte deformability was decreased in rats with diabetes and IR injury. This injury might lead to further problems in microcirculation. Levosimendan may be useful in enhancing the adverse effects of this type of injury (Fig. 2, Ref. 41). Text in PDF www.elis.sk.

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Section: Discussionmentioning

confidence: 99%

Effect of levosimendan on erythrocyte deformability during myocardial ischaemia-reperfusion injury

Arslan¹,

Fm²,

Alkan³

et al. 2015

BLL

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The Protective Role of Nutraceuticals and Functional Food in Hyperlipidemia

Kumar

Rizvi

2019

Nutraceutical and Functional Foods in Disease Prevention

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Diets rich in fats and cholesterol are mainly responsible for the production of free radicals which contribute to the incidence of hyperlipidemia and hypercholesterolemia. Both of these are the major factors responsible for CVDs. Hyperlipidemia is characterized by elevated level of total cholesterol (TC), low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL), and reduced level of high-density lipoprotein (HDL) in serum. The main role of diet is to provide ample amount of nutrients to meet the nutritional requirements of an individual. However, there are increasing scientific approaches helping the hypothesis that some food ingredients have beneficial effects over and above the provision of the basic nutrients. So in this chapter, the main focus is food categorized under nutraceutical and functional food and their various protective roles in the case of hyperlipidemia.

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Effect of tea catechins on erythrocyte Ca⁺⁺-pump in type 2 diabetes mellitus

Cited by 2 publications

References 23 publications

Effect of levosimendan on erythrocyte deformability during myocardial ischaemia-reperfusion injury

Effect of levosimendan on erythrocyte deformability during myocardial ischaemia-reperfusion injury

The Protective Role of Nutraceuticals and Functional Food in Hyperlipidemia

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Effect of tea catechins on erythrocyte Ca++-pump in type 2 diabetes mellitus

Cited by 2 publications

References 23 publications

Effect of levosimendan on erythrocyte deformability during myocardial ischaemia-reperfusion injury

Effect of levosimendan on erythrocyte deformability during myocardial ischaemia-reperfusion injury

The Protective Role of Nutraceuticals and Functional Food in Hyperlipidemia

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Product

Resources

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Effect of tea catechins on erythrocyte Ca⁺⁺-pump in type 2 diabetes mellitus