Effect of Testosterone Replacement on Trabecular Architecture in Hypogonadal Men

Benito, María; Vasilic, Branimir; Wehrli, Félix W.; Bunker, Benjamin; Wald, Michael J.; Gomberg, Bryon R.; Wright, Alexander C.; Zemel, Babette S.; Cucchiara, Andrew J.; Snyder, Peter J.

doi:10.1359/jbmr.050606

Cited by 180 publications

(145 citation statements)

References 27 publications

Supporting

Mentioning

135

Contrasting

Unclassified

Order By: Relevance

“…A further potential motivation is the study of the structural manifestations of metabolic bone disease such as renal osteodystropy (166). Evidence for these developments is the rapid growth of the clinical literature (8,83,84,127,145,165,(167)(168)(169)(170)(171)(172) and also, to a lesser extent, the increased use of CT to characterize TB (14)(15)(16)(173)(174)(175)(176)(177).…”

Section: Clinical Applications Of Trabecular Bone Microstructural Anamentioning

confidence: 99%

“…Several studies reported during the past 3 years examine the structural implications of antiresorptive treatment (84,145,164,172). Benito et al(172) studied the effect of testosterone treatment on architecture in the distal tibial metaphysis of 10 severely testosterone-deficient hypogonadal men and their age-matched controls by means of the MRI-based virtual bone biopsy (19).…”

Section: Clinical Applications Of Trabecular Bone Microstructural Anamentioning

confidence: 99%

See 1 more Smart Citation

Quantitative MRI for the assessment of bone structure and function

et al. 2006

View full text Add to dashboard Cite

Osteoporosis is the most common degenerative disease in the elderly. It is characterized by low bone mass and structural deterioration of bone tissue, leading to morbidity and increased fracture risk in the hip, spine and wrist-all sites of predominantly trabecular bone. Bone densitometry, currently the standard methodology for diagnosis and treatment monitoring, has significant limitations in that it cannot provide information on the structural manifestations of the disease. Recent advances in imaging, in particular MRI, can now provide detailed insight into the architectural consequences of disease progression and regression in response to treatment. The focus of this review is on the emerging methodology of quantitative MRI for the assessment of structure and function of trabecular bone. During the past 10 years, various approaches have been explored for obtaining image-based quantitative information on trabecular architecture. Indirect methods that do not require resolution on the scale of individual trabeculae and therefore can be practiced at any skeletal location, make use of the induced magnetic fields in the intertrabecular space. These fields, which have their origin in the greater diamagnetism of bone relative to surrounding marrow, can be measured in various ways, most typically in the form of R 0 2 , the recoverable component of the total transverse relaxation rate. Alternatively, the trabecular network can be quantified by high-resolution MRI (m-MRI), which requires resolution adequate to at least partially resolve individual trabeculae. Micro-MRI-based structure analysis is therefore technically demanding in terms of image acquisition and algorithms needed to extract the structural information under conditions of limited signal-to-noise ratio and resolution. Other requirements that must be met include motion correction and image registration, both critical for achieving the reproducibility needed in repeat studies. Key clinical applications targeted involve fracture risk prediction and evaluation of the effect of therapeutic intervention.

show abstract

Section: Clinical Applications Of Trabecular Bone Microstructural Anamentioning

confidence: 99%

Section: Clinical Applications Of Trabecular Bone Microstructural Anamentioning

confidence: 99%

Quantitative MRI for the assessment of bone structure and function

et al. 2006

View full text Add to dashboard Cite

show abstract

“…BV/TV, trabecular separation (Tb.Sp), trabecular thickness (Tb.Th) and trabecular number (Tb.N)], digital topologic analysis of μMRIs generates estimates of trabecular connectivity and the conversion of plates to rods [62]. Recent studies demonstrate that these measures improve fracture prediction and are sensitive to structure changes induced by testosterone replacement in hypogonadal men [63] and hormone replacement therapy in women [64].…”

Section: Research Applications: Micro-ct and Micro-mrimentioning

confidence: 99%

A structural approach to the assessment of fracture risk in children and adolescents with chronic kidney disease

Leonard

2007

Pediatr Nephrol

View full text Add to dashboard Cite

Children with chronic kidney disease (CKD) have multiple risk factors for impaired accretion of trabecular and cortical bone. CKD during childhood poses an immediate fracture risk and compromises adult bone mass, resulting in significantly greater skeletal fragility throughout life. Highturnover disease initially results in thickened trabeculae, with greater bone volume. As disease progresses, resorption cavities dissect trabeculae, connectivity degrades, and bone volume decreases. Increased bone turnover also results in increased cortical porosity and decreased cortical thickness. Dual-energy X-ray absorptiometry (DXA)-based measures of bone mineral density (BMD) are derived from the total bone mass within the projected bone area (g/cm 2 ), concealing distinct disease effects in trabecular and cortical bone. In contrast, peripheral quantitative computed tomography (pQCT) estimates volumetric BMD (vBMD, g/cm 3 ), distinguishes between cortical and trabecular bone, and provides accurate estimates of cortical dimensions. Recent data have confirmed that pQCT measures of cortical vBMD and thickness provide substantially greater fracture discrimination in adult dialysis patients compared with hip or spine DXA. The following review considers the structural effects of renal osteodystrophy as it relates to fracture risk and the potential advantages and disadvantages of DXA and alternative measures of bone density, geometry, and microarchitecture, such as pQCT, micro-CT (μCT), and micro magnetic resonance imaging (μMRI) for fracture risk assessment.

show abstract

“…Quantitative musculoskeletal imaging has been employed at standard field strengths to assist in the clinical diagnosis of diseases such as osteoarthritis (OA) and osteoporosis (OP), to monitor the progression of diseases and to evaluate response to treatment with structure/disease-modifying drugs [4][5][6][7]. The measurement of cartilage morphology may provide a biomarker for evaluating the long-term progression of OA.…”

Section: Introductionmentioning

confidence: 99%

Reproducibility of the quantitative assessment of cartilage morphology and trabecular bone structure with magnetic resonance imaging at 7 T

Zuo¹,

Bolbos²,

Hammond³

et al. 2008

Magnetic Resonance Imaging

View full text Add to dashboard Cite

To assess the reproducibility of quantitative measurements of cartilage morphology and trabecular bone structure of the knee at 7 T, high-resolution sagittal spoiled gradient-echo images and highresolution axial fully refocused steady-state free-precession (SSFP) images from six healthy volunteers were acquired with a 7-T scanner. The subjects were repositioned between repeated scans to test the reproducibility of the measurements. The reproducibility of each measurement was evaluated using the coefficient(s) of variation (CV). The computed CV were 1.13% and 1.55% for cartilage thickness and cartilage volume, respectively, and were 2.86%, 1.07%, 2.27% and 3.30% for apparent bone volume over total volume fraction (app.BV/TV), apparent trabecular number (app.Tb.N), apparent trabecular separation (app.Tb.Sp) and apparent trabecular thickness (app.Tb.Th), respectively. The results demonstrate that quantitative assessment of cartilage morphology and trabecular bone structure is reproducible at 7 T and motivates future musculoskeletal applications seeking the high-field strength's superior signal-to-noise ratio.

show abstract

Effect of Testosterone Replacement on Trabecular Architecture in Hypogonadal Men

Cited by 180 publications

References 27 publications

Quantitative MRI for the assessment of bone structure and function

Quantitative MRI for the assessment of bone structure and function

A structural approach to the assessment of fracture risk in children and adolescents with chronic kidney disease

Reproducibility of the quantitative assessment of cartilage morphology and trabecular bone structure with magnetic resonance imaging at 7 T

Contact Info

Product

Resources

About