Effect of the aggregation state of bile salts on their transdermal absorption enhancing properties

Álvarez-Figueroa, María Javiera; Muggli-Galaz, Camila; González, Pablo M.

doi:10.1016/j.jddst.2019.101333

Cited by 6 publications

(1 citation statement)

References 47 publications

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“…The most widespread bile salts considered in recent reports are cholate, deoxycholate and taurodeoxycholate. Sodium cholate is known for its capability to act as a transdermal enhancer [ 84 ] and additive to mono- and dicationic surfactant solutions significantly modifying their morphological behavior [ 85 ] and release profile of cargo encapsulated in self-assembled drug nanovehicles [ 86 ]. Sodium deoxycholate was reported as part of biamphiphiles, ionic compounds with both cationic and anionic amphiphilic nature, which aggregate shape could be accurately controlled [ 87 ]; micellar catalyst for the synthesis of 1,2,3-triazole derivatives; their characteristics is superior in comparison with those of conventional surfactants CTAB and Triton-X-100 [ 88 ].…”

Section: Self-assembly Of Amphiphilic Compoundsmentioning

confidence: 99%

Self-Assembly of Amphiphilic Compounds as a Versatile Tool for Construction of Nanoscale Drug Carriers

Kashapov

Gaynanova

Gabdrakhmanov

et al. 2020

IJMS

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This review focuses on synthetic and natural amphiphilic systems prepared from straight-chain and macrocyclic compounds capable of self-assembly with the formation of nanoscale aggregates of different morphology and their application as drug carriers. Since numerous biological species (lipid membrane, bacterial cell wall, mucous membrane, corneal epithelium, biopolymers, e.g., proteins, nucleic acids) bear negatively charged fragments, much attention is paid to cationic carriers providing high affinity for encapsulated drugs to targeted cells. First part of the review is devoted to self-assembling and functional properties of surfactant systems, with special attention focusing on cationic amphiphiles, including those bearing natural or cleavable fragments. Further, lipid formulations, especially liposomes, are discussed in terms of their fabrication and application for intracellular drug delivery. This section highlights several features of these carriers, including noncovalent modification of lipid formulations by cationic surfactants, pH-responsive properties, endosomal escape, etc. Third part of the review deals with nanocarriers based on macrocyclic compounds, with such important characteristics as mucoadhesive properties emphasized. In this section, different combinations of cyclodextrin platform conjugated with polymers is considered as drug delivery systems with synergetic effect that improves solubility, targeting and biocompatibility of formulations.

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