Effect of the calpain small subunit 1 gene ( CAPNS1 ) polymorphism on meat quality traits in sheep

Grochowska, Ewa; Borys, B.; Grześkowiak, E.; Mroczkowski, S.

doi:10.1016/j.smallrumres.2017.02.022

Cited by 10 publications

(8 citation statements)

References 37 publications

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“…Our findings could be applied on future selection scheme in Valle del Belice breed oriented towards milk yield and milk composition (protein and fat content) to maintain competitiveness of these products. The CAPNS1 gene (CNVR_17) showed significant effects on natural drip loss, lightness and intramuscular fat content in sheep [54].…”

Section: Resultsmentioning

confidence: 99%

Genome-wide association study between CNVs and milk production traits in Valle del Belice sheep

et al. 2019

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Copy number variation (CNV) is a major source of genomic structural variation. The aim of this study was to detect genomic CNV regions (CNVR) in Valle del Belice dairy sheep population and to identify those affecting milk production traits. The GO analysis identified possible candidate genes and pathways related to the selected traits. We identified CNVs in 416 individuals genotyped using the Illumina OvineSNP50 BeadChip array. The CNV association using a correlation-trend test model was examined with the Golden Helix SVS 8.7.0 tool. Significant CNVs were detected when their adjusted p-value was <0.01 after false discovery rate (FDR) correction. We identified 7,208 CNVs, which gave 365 CNVRs after aggregating overlapping CNVs. Thirty-one CNVRs were significantly associated with one or more traits included in the analysis. All CNVRs, except those on OAR19, overlapped with quantitative trait loci (QTL), even if they were not directly related to the traits of interest. A total of 222 genes were annotated within the significantly associated CNVRs, most of which played important roles in biological processes related to milk production and health-related traits. Identification of the genes in the CNVRs associated with the studied traits will provide the basis for further investigation of their role in the metabolic pathways related to milk production and health traits.

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Section: Resultsmentioning

confidence: 99%

Genome-wide association study between CNVs and milk production traits in Valle del Belice sheep

et al. 2019

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“…Así mismo, se ha reportado que el gen Fabp4 está asociado al parámetro, donde reportan la identificación de los genotipos AA, AG y GG; el genotipo AA presentó un menor porcentaje de pérdida (8.86, 9.48 y 9.39 %, respectivamente), aunque estadísticamente no hubo diferencias significativas (P<0.1) (97) . Así mismo, polimorfismos en el gen Calpaína Subunidad 1 (Capns1) han sido asociados a CRA, identificando cinco genotipos con diferencia en el porcentaje de pérdida de humedad (P<0.01); el genotipo B1B1 presentó 4.11 % mientras que los genotipos A1A1, A1B1, A1C1 y B1C1 estuvieron en un rango de 2.23 a 3.30 % (14) . Además, dos genotipos en el gen de la Insulina como Factor de Crecimiento 1 (Igf-1) con efectos significativos sobre la pérdida por goteo han sido reportados, el genotipo homocigoto AA registró un 2.47 % de pérdida, mientras que el heterocigoto AB un 3.33 % (106) .…”

Section: Capacidad De Retención De Agua (Cra)unclassified

“…El interés de la industria cárnica no solo es en la eficiencia del uso del alimento, sino también en la calidad del producto destinado al mercado. La calidad de la carne se compone de varios rasgos, incluidos los atributos fisicoquímicos (terneza, color, contenido de grasa intramuscular y la capacidad de retención de agua) y los factores que afectan la palatabilidad (sabor, jugosidad y olor), así como las características de inocuidad (13) , los cuales influyen en la toma de decisión del cliente al elegir un tipo de corte, así como también para la industria en el procesamiento de la carne (14) . En este sentido, se han realizado diversos estudios que emplearon la herramienta CAR para determinar el efecto de la eficiencia alimenticia sobre la calidad de la carne, reportando que la selección de bovinos Angus eficientes (bajo CAR) no afecta negativamente la calidad de carne producida (15,16) .…”

Section: Introductionunclassified

Índices de eficiencia alimenticia en ovinos de pelo: calidad de la carne y genes asociados. Revisión

Arce-Recinos

Chay-Canul

Alarcón-Zúñiga

et al. 2021

Rev. Mex. Cienc. Pecu.

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Los ovinos de pelo desempeñan un papel importante en la producción de carne en zonas tropicales, donde los estudios de eficiencia alimenticia han sido poco evaluados. El consumo de alimento representa más del 70 % de los costos; por lo tanto, la selección de animales con alta eficiencia alimenticia puede mejorar la rentabilidad del sistema de producción. Se han desarrollado herramientas que permiten seleccionar individuos con mayor eficiencia alimenticia sin comprometer la calidad del producto. Por lo que esta revisión tiene la finalidad de identificar estas herramientas genético-moleculares y estadísticas, como son, el consumo de alimento residual (CAR) y ganancia e ingesta residual (GIR). En la literatura consultada, se reportan diferencias en el consumo de materia seca (CMS) en un rango del 9 al 30 % entre animales eficientes e ineficientes, manteniendo una ganancia diaria de peso (GDP) similar empleando el índice CAR. Por otro lado, utilizando el índice GIR los CMS son similares, aunque la GDP en animales eficientes es mayor hasta en 50 g día-1, reduciendo la conversión alimenticia en un kilo. Esta diferencia se asume a un conjunto de genes asociados a la eficiencia alimenticia (Adra2a, Gfra1, Gh, Glis1, Il1rapl1, Lep, Lepr, Mc4r, Oxsm, Pde8b, Rarb, Ryr2, Sox5 y Sox6, Trdn), que pudieran ser utilizados para la selección de ovinos de razas de pelo con alta eficiencia alimenticia, teniendo en cuenta los genes relacionados con la calidad de carne (Capns1, Cast, Dgat1, Fabp4, Igf-i, Lep, Mstn y Scd).

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“…Previous studies have shown that the calpain system is closely related to meat quality traits in pigs (Gandolfi et al, 2011), sheep (Grochowska et al, 2017), and chickens (Zhang et al, 2009). Calpains are Ca 2+ -dependent intracellular cysteine proteases that are involved in cell motility (Glading et al, 2002), and apoptosis regulation (Liu et al, 2004), muscle atrophy (Richard et al, 1995), myoblast fusion (Honda et al, 2008), and muscle growth and develop-ment (Sultan et al, 2000;Zhang et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Characterization of the Goose <i>CAPN3</i> Gene and its Expression Pattern in Muscle Tissues of Sichuan White Geese at Different Growth Stages

Zhang

Zou

et al. 2018

J. Poult. Sci.

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Calpain 3 (CAPN3), also known as p94, is associated with multiple production traits in domestic animals. However, the molecular characteristics of the CAPN3 gene and its expression profile in goose tissues have not been reported. In this study, CAPN3 cDNA of the Sichuan white goose was cloned, sequenced, and characterized. The CAPN3 full-length cDNA sequence consists of a 2,316-bp coding sequence (CDS) that encodes 771 amino acids with a molecular mass of 89,019 kDa. The protein was predicted to have no signal peptide, but several N-glycosylation, Oglycosylation, and phosphorylation sites. The secondary structure of CAPN3 was predicted to be 38.65% α-helical. Sequence alignment showed that CAPN3 of Sichuan white goose shared more than 90% amino acid sequence similarity with those of Japanese quail, turkey, helmeted guineafowl, duck, pigeon, and chicken. Phylogenetic tree analysis showed that goose CAPN3 has a close genetic relationship and small evolutionary distance with those of the birds. qRT-PCR analysis showed that in 15-day-old animals, the expression level of CAPN3 was significantly higher in breast muscle than in thigh tissues. These results serve as a foundation for further investigations of the function of the goose CAPN3 gene.

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Effect of the calpain small subunit 1 gene ( CAPNS1 ) polymorphism on meat quality traits in sheep

Cited by 10 publications

References 37 publications

Genome-wide association study between CNVs and milk production traits in Valle del Belice sheep

Genome-wide association study between CNVs and milk production traits in Valle del Belice sheep

Índices de eficiencia alimenticia en ovinos de pelo: calidad de la carne y genes asociados. Revisión

Characterization of the Goose <i>CAPN3</i> Gene and its Expression Pattern in Muscle Tissues of Sichuan White Geese at Different Growth Stages

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