Effect of the function of polymorphonuclear leukocytes and interleukin-1 beta on wound healing in patients with diabetic foot infections

Human monocyte activation by biologic and biodegradable meshes in vitro

“…Interleukin-1b is a key regulatory cytokine necessary for the integration of implanted biomaterials. It acts as a principal inducer of the acute inflammatory response, with functions including stimulation of the acute phase response and hematopoiesis as well as promotion of wound-healing functions via fibroblast activation and recruitment [23][24][25].…”

Phagocytic activity of neutrophils improves over the course of therapy of diabetic foot infections

“…Öncül et al had reported that the PMNL functions and IL-1beta regulation deteriorated in patients with diabetic foot infection, and that such deteriorations might indicate inefficient therapeutic responses in patients with diabetes mellitus. 7 Os xar et al had reported that impaired neutrophil functions could aggravate various infections in patients with diabetes mellitus and blood glucose regulation was an important target of treatment to improve neutrophil functions. 6 Peck et al had performed a study to evaluate the effect of granulocyte-colony stimulating factor (G-CSF) on neutrophil functions in diabetic patients with active foot infections in vitro.…”

Radiotherapy and wound healing: Principles, management and prospects (Review)

“…Polymorphonuclear leukocytes (PMNs) now become the predominant cells in the wound, with especially high numbers on the second day. their nucleus is so deeply lobated or divided that the cell looks like it has multiple nuclei (30). In addition to the above mentioned growth factors and kinins, cells are also attracted by fibronectin.…”