“…This might be overcome by targeted intervention to improve oxygenation [8,33,34] or by use of hypoxic cell sensitizers [25]. In breast cancer, hypoxia-induced pathways have been found to lead to a dedifferentiated, aggressive phenotype [10,11,15,19,28,29] and impaired response to radiotherapy [13,19,27,28], chemo-and hormonal therapy [6,7,11,15,28,29].…”