Effect of the kaurenoic acid on genotoxicity and cell cycle progression in cervical cancer cells lines

Rocha, Silvia; Cardoso, Plínio Cerqueira dos Santos; Bahia, Marcelo de Oliveira; Pessoa, Cláudia; Soares, Paulo Cardoso; Rocha, Simone Machado da; Burbano, Rommel Rodrı́guez; Rocha, Carla

doi:10.1016/j.tiv.2019.02.022

Cited by 16 publications

(7 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Treatment with KA increased the expression of TP53 in gastric cancer cell lines. KA was also genotoxic to the cervical cancer cells HeLa, CaSki, and C33 A; it modulated the expression of DNA damage response pathway genes and inhibited the expression of the HPV E6 and E7 oncogenes . In the present study, the biological effects of KA were observed at 50 and 100 μM.…”

Section: Analysis Of Cell Cycle and Cell Deathsupporting

confidence: 49%

“…KA was also genotoxic to the cervical cancer cells HeLa, CaSki, and C33 A; it modulated the expression of DNA damage response pathway genes and inhibited the expression of the HPV E6 and E7 oncogenes. [12] In the present study, the biological effects of KA were observed at 50 and 100 μM. This is a question to be solved when we consider the importance of exploring the antiproliferative effects of KA in vivo under physiological conditions.…”

Section: Analysis Of Cell Cycle and Cell Deathmentioning

confidence: 79%

See 1 more Smart Citation

Kaurenoic Acid Induces Cell Cycle Arrest and Apoptosis in the MCF‐7 Breast Cancer Cell Line

et al. 2020

View full text Add to dashboard Cite

Breast cancer continues to be the major cause of cancer death among women. The high genetic heterogeneity and chemoresistant phenotypes of breast tumors require the search for new compounds to expand the options for the treatment of this disease. Kaurenoic acid (KA) is an ent-kaurane typediterpene with cytotoxic and genotoxic effects against gastric and cervical cancer cells. In the present study, we report the antiproliferative effects of KA in the breast tumoral cell line MCF-7 and the normal breast counterpart MCF-10 A. The longterm cytotoxic effects of KA were observed by the reduction of survival fraction at 50 and 100 μM. At these concentrations, the treatment with KA increased the extension of DNA damage followed by G1 cell cycle phase accumulation and induction of apoptosis in both cell lines. Taken together, the results contained herein support the promising antiproliferative effects of KA.

show abstract

Section: Analysis Of Cell Cycle and Cell Deathsupporting

confidence: 49%

Section: Analysis Of Cell Cycle and Cell Deathmentioning

confidence: 79%

Kaurenoic Acid Induces Cell Cycle Arrest and Apoptosis in the MCF‐7 Breast Cancer Cell Line

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Kaur-16-en-18-oic acid is a kaurane-type diterpenoid which has anticancer potential [42]. It has been reported that kaur-16-en-18-oic acid induces apoptosis cell death in HL-60 [43], HeLa and CaSki cervical cancer cell lines [44], including a significant anti-cancer effect against an A549 cell line [45].…”

Section: Discussionmentioning

confidence: 99%

Potential of Thai Herbal Extracts on Lung Cancer Treatment by Inducing Apoptosis and Synergizing Chemotherapy

et al. 2020

View full text Add to dashboard Cite

The incidence of lung cancer has increased while the mortality rate has continued to remain high. Effective treatment of this disease is the key to survival. Therefore, this study is a necessity in continuing research into new effective treatments. In this study we determined the effects of three different Thai herbs on lung cancer. Bridelia ovata, Croton oblongifolius, and Erythrophleum succirubrum were extracted by ethyl acetate and 50% ethanol. The cytotoxicity was tested with A549 lung cancer cell line. We found four effective extracts that exhibited toxic effects on A549 cells. These extracts included ethyl acetate extracts of B. ovata (BEA), C. oblongifolius (CEA), and E. succirubrum (EEA), and an ethanolic extract of E. succirubrum (EE). Moreover, these effective extracts were tested in combination with chemotherapeutic drugs. An effective synergism of these treatments was found specifically through a combination of BEA with methotrexate, EE with methotrexate, and EE with etoposide. Apoptotic cell death was induced in A549 cells by these effective extracts via the mitochondria-mediated pathway. Additionally, we established primary lung cancer and normal epithelial cells from lung tissue of lung cancer patients. The cytotoxicity results showed that EE had significant potential to be used for lung cancer treatment. In conclusion, the four effective extracts possessed anticancer effects on lung cancer. The most effective extract was found to be E. succirubrum (EE).

show abstract

“…Brazilian research is also represented in this scientific production. For example, in vitro tests of substances against cancer cells, such as kaurenoic acid, tested against gastric cancer strains (Cardoso et al, 2017) and cervical cancer (Rocha et al, 2019) have been published. In both cases, the treatment significantly reduced the transcription of the BCL2 and MYC oncogenes, in addition to increasing the transcription of the ATM, CHK and TP53 genes.…”

Section: Resultsmentioning

confidence: 99%

Mapping Scientific and Technological Production Related to the MYC Gene

Silva¹

2021

revistageintec

View full text Add to dashboard Cite

In appropriate activation of c-MYC proto-oncogene contributes to the development of human cancers. Searches for therapies that target genes and proteins related to neoplastic phenotypes have become frequent. Therefore, inhibiting c-MYC expression has been the target for developing and testing multiple drugs and strategies for the treatment of various human cancers. This study aimed to map scientific and technological productions on the MYC gene at the Scielo, PubMed and Orbit Intelligence platforms between 2000 and 2019. The scientific prospecting revealed 1,259 articles. The most detected categories were: molecular biology, MYC mutations and those addressing the MYC as a drug target or therapeutic strategies. A progressive increase in the number of articles in this last category was found. Technological mapping detected 10,059 patent documents, with 20.2% granted. China and the USA were the largest filers, accounting for more than 40%. Biotechnology was the field with the highest number of patents. Biotechnology and the pharmaceutical sector predominated in the second half of the period investigated, both in scientific and technological prospecting. Our study points to a scientific and technological effort in the development of therapeutic strategies against cancer, in which MYC is among the main targets.

show abstract

Effect of the kaurenoic acid on genotoxicity and cell cycle progression in cervical cancer cells lines

Cited by 16 publications

References 33 publications

Kaurenoic Acid Induces Cell Cycle Arrest and Apoptosis in the MCF‐7 Breast Cancer Cell Line

Kaurenoic Acid Induces Cell Cycle Arrest and Apoptosis in the MCF‐7 Breast Cancer Cell Line

Potential of Thai Herbal Extracts on Lung Cancer Treatment by Inducing Apoptosis and Synergizing Chemotherapy

Mapping Scientific and Technological Production Related to the MYC Gene

Contact Info

Product

Resources

About