Effect of the Lipid Peroxidation Product 4-Hydroxynonenal on Neuroinflammation in Microglial Cells: Protective Role of Quercetin and Monochloropivaloylquercetin

Cumaoğlu, Ahmet; Agkaya, Asli Ozge; Ozkul, Zehra

doi:10.4274/tjps.58966

Cited by 7 publications

(3 citation statements)

References 54 publications

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“…The low bioavailability often led to the use of high QUE doses to achieve measurable outcomes. Different QUE formulations were developed to increase bioavailability following PO administration 66,67 . Many different strategies were tested, such as nanoparticle‐based and by immersion in oil 12,37,38 .…”

Section: Discussionmentioning

confidence: 99%

“…Different QUE formulations were developed to increase bioavailability following PO administration. 66,67 Many different strategies were tested, such as nanoparticle-based and by immersion in oil. 12,37,38 In QUE-loaded nanoparticles, QUE molecules are encapsulated into lipidic nanocarriers, increasing permeability across biological barriers, bioavailability and efficacy of QUE nanocrystals exceeded those of free QUE.…”

Section: Strategies To Improve Que Bioavailabilitymentioning

confidence: 99%

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Effects of quercetin in preclinical models of Parkinson's disease: A systematic review

de Oliveira Vian,

Marinho,

da Silva Marques

et al. 2024

Basic Clin Pharma Tox

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Parkinson's disease (PD) is a neurodegenerative disease that affects dopaminergic neurons, thus impairing dopaminergic signalling. Quercetin (QUE) has antioxidant and neuroprotective properties that are promising for the treatment of PD. This systematic review aimed to investigate the therapeutic effects of QUE against PD in preclinical models. The systematic search was performed in PubMed, Scopus and Web of Science. At the final screening stage, 26 articles were selected according to pre‐established criteria. Selected studies used different methods for PD induction, as well as animal models. Most studies used rats (73.08%) and mice (23.08%), with 6‐OHDA as the main strategy for PD induction (38.6%), followed by rotenone (30.8%). QUE was tested immersed in oil, nanosystems or in free formulations, in varied routes of administration and doses, ranging from 10 to 400 mg/kg and from 5 to 200 mg/kg in oral and intraperitoneal administrations, respectively. Overall, evidence from published data suggests a potential use of QUE as a treatment for PD, mainly through the inhibition of oxidative stress, neuroinflammatory response and apoptotic pathways.

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Section: Discussionmentioning

confidence: 99%

Section: Strategies To Improve Que Bioavailabilitymentioning

confidence: 99%

Effects of quercetin in preclinical models of Parkinson's disease: A systematic review

de Oliveira Vian,

Marinho,

da Silva Marques

et al. 2024

Basic Clin Pharma Tox

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“…Deltamethrin exposure significantly increased protein levels of 4-HNE in MMCs, and was correlated with the production of ROS and inflammatory cytokines. Several studies have shown that 4-HNE acts as a critical signaling molecule that triggers inflammatory responses after the induction of oxidative stress in microglia and astrocytes [ 73 , 74 , 75 ]. These results suggest that an imbalance in antioxidant homeostasis and oxidative stress triggers an inflammatory response through ER stress pathways, following exposure to deltamethrin.…”

Section: Discussionmentioning

confidence: 99%

Deltamethrin-Evoked ER Stress Promotes Neuroinflammation in the Adult Mouse Hippocampus

Hossain

Toltin

Gamba

et al. 2022

Cells

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Endoplasmic reticulum (ER) stress and neuroinflammation are involved in the pathogenesis of many neurodegenerative disorders. Previously, we reported that exposure to pyrethroid insecticide deltamethrin causes hippocampal ER stress, apoptosis, a reduction in neurogenesis, and learning deficits in adult male mice. Recently, we found that deltamethrin exposure also increases the markers of neuroinflammation in BV2 cells. Here, we investigated the potential mechanistic link between ER stress and neuroinflammation following exposure to deltamethrin. We found that repeated oral exposure to deltamethrin (3 mg/kg) for 30 days caused microglial activation and increased gene expressions and protein levels of TNF-α, IL-1β, IL-6, gp91phox, 4HNE, and iNOS in the hippocampus. These changes were preceded by the induction of ER stress, as the protein levels of CHOP, ATF-4, and GRP78 were significantly increased in the hippocampus. To determine whether induction of ER stress triggers the inflammatory response, we performed an additional experiment with mouse microglial cell (MMC) line. MMCs were treated with 0–5 µM deltamethrin for 24–48 h in the presence or absence of salubrinal, a pharmacological inhibitor of the ER stress factor eIF2α. We found that salubrinal (50 µM) prevented deltamethrin-induced ER stress, as indicated by decreased levels of CHOP and ATF-4, and attenuated the levels of GSH, 4-HNE, gp91phox, iNOS, ROS, TNF-α, IL-1β, and IL-6 in MMCs. Together, these results demonstrate that exposure to deltamethrin leads to ER stress-mediated neuroinflammation, which may subsequently contribute to neurodegeneration and cognitive impairment in mice.

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Chlorogenic acid, quercetin, coenzyme Q10 and silymarin modulate Keap1-Nrf2/heme oxygenase-1 signaling in thioacetamide-induced acute liver toxicity

et al. 2021

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Effect of the Lipid Peroxidation Product 4-Hydroxynonenal on Neuroinflammation in Microglial Cells: Protective Role of Quercetin and Monochloropivaloylquercetin

Cited by 7 publications

References 54 publications

Effects of quercetin in preclinical models of Parkinson's disease: A systematic review

Effects of quercetin in preclinical models of Parkinson's disease: A systematic review

Deltamethrin-Evoked ER Stress Promotes Neuroinflammation in the Adult Mouse Hippocampus

Chlorogenic acid, quercetin, coenzyme Q10 and silymarin modulate Keap1-Nrf2/heme oxygenase-1 signaling in thioacetamide-induced acute liver toxicity

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