Effect of the native polysaccharide of cashew-nut tree gum exudate on murine peritoneal macrophage modulatory activities

Topical protection of mice laryngeal mucosa using the natural product cashew gum

“…Cashew gum is a nontoxic, stable, easily available, biodegradable, and inexpensive substance . Recent studies have demonstrated that the anti‐inflammatory properties and gastrointestinal protective activity of cashew gum is in part associated with the inhibition of oxidative stress . Such pharmacological features may be useful in LPR therapy, because this condition is associated with inflammatory and oxidative stress .…”

“…Recent studies have demonstrated that the anti‐inflammatory properties and gastrointestinal protective activity of cashew gum is in part associated with the inhibition of oxidative stress . Such pharmacological features may be useful in LPR therapy, because this condition is associated with inflammatory and oxidative stress . Although additional experiments using human larynxes and in vivo models are necessary, and the risk of laryngospasm caused by the application of CG on laryngeal mucosa must be considered, these results may indicate a novel approach to LPR treatment.…”

“…Recently, it has been demonstrated that the esophageal mucosa can be topically protected in vitro from the damage produced by the components of gastroesophageal refluxate . Cashew gum, a natural polymer obtained from the resin of a Brazilian northeastern tree ( Anacardium occidentale L.), is a biomacromolecule with adhesive properties and anti‐inflammatory and gastro‐protective characteristics in animal models . Experiments in our lab showed that precoating human esophageal biopsies with cashew gum solution confers protection against acidic solution containing pepsin and bile acids …”

“…11,12 Cashew gum, a natural polymer obtained from the resin of a Brazilian northeastern tree (Anacardium occidentale L.), is a biomacromolecule with adhesive properties and anti-inflammatory and gastro-protective characteristics in animal models. 13,14 Experiments in our lab showed that precoating human esophageal biopsies with cashew gum solution confers protection against acidic solution containing pepsin and bile acids. 15 To the best of our knowledge, there are no studies regarding the effect of any topical protectant solution against the damage caused by refluxate components to the laryngeal mucosa.…”

Influences of Hyriopsis cumingii polysaccharides on mice immunosignaling molecules and T lymphocyte differentiation

“…IL-10 could suppress the antigen presentation ability of DCs, monocytes and macrophages, all of which are required for optimal pathogen clearance (Mittal & Roche, 2015). During inflammation, IL-10 may act in a negative feedback mechanism to prevent deleterious effects from excessive macrophage activation (Yamassaki et al, 2015). This result, crude HCPS by gastric gavage could improve the production of IL-2 and IFN-γ, and inhibit the production of IL-10 in a dose-dependent manner, implied that: When HCPS executed their immunostimulatory activities, IL-2 and IFN-γ might be induced and act as the immune regulators modulating innate and adaptive immune responses, IL-10 might be suppressed and act in a negative feedback mechanism to protect host from excessive tissue damage.…”