Effect of the phenolic compounds apigenin and carnosic acid on oral carcinogenesis in hamster induced by <scp>DMBA</scp>

Gómez-García, FJ; López-Jornet, M.P.; Álvarez-Sánchez, Nuria; Castillo-Sánchez, Julián; Benavente-García, Obdulio; Ortega, Vicente Vicente

doi:10.1111/j.1601-0825.2012.01975.x

Cited by 20 publications

(9 citation statements)

References 61 publications

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“…Inhibition of tumor formation by carnosic acid was associated with restoration of normal levels of detoxification phase I and phase II enzymes. The chemoprotective effect of carnosic acid against oral carcinogenesis was also evident in another study conducted on Syrian hamsters wherein tumor volume of DMBA+carnosic acid treated animals was 1.05mm 3 compared to 137.74mm 3 in DMBA control hamsters [38].…”

Section: In Vivo Studiesmentioning

confidence: 61%

Diterpenes from rosemary (Rosmarinus officinalis): Defining their potential for anti-cancer activity

2015

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Section: In Vivo Studiesmentioning

confidence: 61%

Diterpenes from rosemary (Rosmarinus officinalis): Defining their potential for anti-cancer activity

2015

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“…In addition, a 15-week period of oral administration of apigenin (2.5 mg/kg) in hamsters resulted in reduction of tumor volume and incidence, modulation of cell proliferation, apoptosis, inflammation, and angiogenesis markers, and modulation of phase I and II detoxification cascades in a 7,12-dimethyl benz[ a ]anthracene (DMBA)-induced experimental oral carcinogenesis model 16,17. The chemoprotective effect of apigenin against oral carcinogenesis was further supported by studies reporting that this flavone lowered tumor incidence in DMBA-induced animal model 18,19. Wei et al20 investigated the potential chemopreventive effects of apigenin on murine skin tumorigenesis initiated by DMBA and promoted by 12-O-tetradecanoylphorbol-13-acetate in SENCAR mice.…”

Section: Role Of Apigenin In Cancer Preventionmentioning

confidence: 85%

Role of Apigenin in Cancer Prevention via the Induction of Apoptosis and Autophagy

2016

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Apigenin (4′,5,7-trihydroxyflavone) is a flavonoid commonly found in many fruits and vegetables such as parsley, chamomile, celery, and kumquats. In the last few decades, recognition of apigenin as a cancer chemopreventive agent has increased. Significant progress has been made in studying the chemopreventive aspects of apigenin both in vitro and in vivo. Several studies have demonstrated that the anticarcinogenic properties of apigenin occur through regulation of cellular response to oxidative stress and DNA damage, suppression of inflammation and angiogenesis, retardation of cell proliferation, and induction of autophagy and apoptosis. One of the most well-recognized mechanisms of apigenin is the capability to promote cell cycle arrest and induction of apoptosis through the p53-related pathway. A further role of apigenin in chemoprevention is the induction of autophagy in several human cancer cell lines. In this review, we discuss the details of apigenin, apoptosis, autophagy, and the role of apigenin in cancer chemoprevention via the induction of apoptosis and autophagy.

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“…Furthermore, expression of detoxification enzymes was enhanced [83], markers of apoptosis including p53, Bax, Bcl-2 and caspases were increased [84], and regulators of cell growth including COX-2, c-fos, KF-κB and cyclin D1 were decreased [84]. Using the same hamster model, 750 µg CA dissolved in 0.1mL saline (20 µM) administered daily for 11 weeks significantly slowed the progression of lesions and oral cancer development [85]. In mice xenografted with prostate samples from human biopsies, 100 mg CA dissolved in 100 µL of cottonseed oil administered daily for 25 days decreased tumor growth [86].…”

Section: Anticancer Effects Of Carnosic Acid (Ca): In Vivo Animal mentioning

confidence: 99%

Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols

2016

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Cancer cells display enhanced growth rates and a resistance to apoptosis. The ability of cancer cells to evade homeostasis and proliferate uncontrollably while avoiding programmed cell death/apoptosis is acquired through mutations to key signaling molecules, which regulate pathways involved in cell proliferation and survival. Compounds of plant origin, including food components, have attracted scientific attention for use as agents for cancer prevention and treatment. The exploration into natural products offers great opportunity to evaluate new anticancer agents as well as understand novel and potentially relevant mechanisms of action. Rosemary extract has been reported to have antioxidant, anti-inflammatory, antidiabetic and anticancer properties. Rosemary extract contains many polyphenols with carnosic acid and rosmarinic acid found in highest concentrations. The present review summarizes the existing in vitro and in vivo studies focusing on the anticancer effects of rosemary extract and the rosemary extract polyphenols carnosic acid and rosmarinic acid, and their effects on key signaling molecules.

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Effect of the phenolic compounds apigenin and carnosic acid on oral carcinogenesis in hamster induced by DMBA

Abstract: Our findings indicate that both potassium apigenin and carnosic acid have chemoprotective effects against carcinogenesis induced by DMBA in hamster.

Cited by 20 publications

References 61 publications

Diterpenes from rosemary (Rosmarinus officinalis): Defining their potential for anti-cancer activity

Diterpenes from rosemary (Rosmarinus officinalis): Defining their potential for anti-cancer activity

Role of Apigenin in Cancer Prevention via the Induction of Apoptosis and Autophagy

Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols

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