Effect of the physicochemical properties of initially injected liposomes on the clearance of subsequently injected PEGylated liposomes in mice

Ishida, Tatsuhiro; Ichikawa, Takako; Ichihara, Masako; Sadzuka, Yasuyuki; Kojima, Hiroshi

doi:10.1016/j.jconrel.2003.12.011

Cited by 109 publications

(62 citation statements)

References 36 publications

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“…The same animal models may also have various results when the parameters such as interval time of injection, PL dose, PEG-DSPE concentration and model drug differ. For example, Dams et al (2000) reported that the ABC phenomenon is not observed in mice, but Ishida et al (2004) found a significant ABC phenomenon using the same animal model. Therefore, we evaluated whether different animal models had different responses to the repeated injections of PEGylated liposomes.…”

Section: Effect Of Different Animal Models On Abc Phenomenonmentioning

confidence: 97%

“…Rats and mice were also included in the investigation. It is possible that different animals have different kinetics of triggering the ABC effect, for example the peak effect of rats is 5 to 7 days after initial sensitization, but the peak effect of mice is 10 days (Ishida et al, 2004). The injection interval was determined 6 days and the aim is to fix all variables and only compare ABC phenomenon of different animals.…”

Section: Effect Of Different Animal Models On Abc Phenomenonmentioning

confidence: 99%

“…Dams et al (2000) found that rhesus monkeys and rats, but not mice, can produce the ABC phenomenon by repeated injections of PEGylated liposomes. Ishida et al (2004) showed that an intense ABC phenomenon can be induced in mice. Tagami et al (2009) used mice as an animal model to investigate the ABC phenomenon and proved that repeated injections of liposome-encapsulated siRNA in mice can induce an intense ABC phenomenon.…”

Section: Introductionmentioning

confidence: 99%

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Influence of phospholipid types and animal models on the accelerated blood clearance phenomenon of PEGylated liposomes upon repeated injection

et al. 2014

Drug Delivery

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(2015) Influence of phospholipid types and animal models on the accelerated blood clearance phenomenon of PEGylated liposomes upon repeated injection, Drug Delivery, 22:5, 598-607, DOI: 10.3109/10717544.2014 AbstractWhen polyethylene glycol (PEG)ylated liposomes were repeatedly injected into the same animal, the second dose of liposomes would rapidly clear from the bloodstream and enhance accumulation in the liver and spleen, and this phenomenon is called ''accelerated blood clearance (ABC)''. There are many factors known to influence ABC phenomenon, in this study, we mainly focused on the effects of different phospholipids (PL) types and animal models. The effects of PL types on ABC phenomenon were examined by repeating injection of PEGylated liposomes prepared by five different types of PL (hydrogenated soy phosphatidylcholine, egg sphingomyelin, soybean phosphatidycholin, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine and egg phosphatidycholin) in rats. Dramatically, repeated injection of different types of PL could induce ABC phenomenon altogether. Both t 1/2 and AUC of experimental group (EG) were lower significantly than those of control group (CG). Our results also showed that the liver accumulation of second dose increased significantly (p50.01) in all EG as compared that of CG. Interestingly, ABC phenomenon of liposomes prepared by unsaturated PL was more obvious than that of saturated PL. All the first dose could induce the antibody (anti-PEG IgM) level increasing significantly (p50.01). For different animal models, we found that after repeated injection of PEGylated liposomes, rats, mice, rabbits and guinea pigs could produce ABC phenomenon. Various PL types and animal models could all produce the ABC phenomenon. However, their extent of accelerated clearance differed. ABC phenomenon is possibly a ubiquitous immune phenomenon in life.

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Section: Effect Of Different Animal Models On Abc Phenomenonmentioning

confidence: 97%

Section: Effect Of Different Animal Models On Abc Phenomenonmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Influence of phospholipid types and animal models on the accelerated blood clearance phenomenon of PEGylated liposomes upon repeated injection

et al. 2014

Drug Delivery

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“…The ABC phenomenon has already been widely reported in mice, 27 rats, 28,29 rabbits, 30 and rhesus monkeys. 7 Instead of these animals, the beagle was selected as the primary experimental subject in the present study.…”

Section: Introductionmentioning

confidence: 79%

Repeated injection of PEGylated solid lipid nanoparticles induces accelerated blood clearance in mice and beagles

Zhao¹,

Wang²,

Yan³

et al. 2012

IJN

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Surface modification of nanocarriers with amphiphilic polymer polyethylene glycol (PEG), known as PEGylation, is regarded as a major breakthrough in the application of nanocarriers. However, PEGylated nanocarriers (including liposomes and polymeric nanoparticles) induce what is referred to as the "accelerated blood clearance (ABC) phenomenon" upon repeated injection and consequently they lose their sustained circulation characteristics. Despite this, the present authors are not aware of any reports of accelerated clearance due to repeated injection for PEGylated solid lipid nanoparticles (SLNs), another promising nanocarrier. This study investigated the pharmacokinetics of PEGylated SLNs upon repeated administration in mice; moreover, the impact of circulation time on the induction of the ABC phenomenon was studied in beagles for the first time. The ABC index, selected as the ratio of the area under the concentration-time curve from time 0 to the last measured concentration of a second injection to that of the first injection, was used to evaluate the extent of this phenomenon. Results showed that the PEGylated SLNs exhibited accelerated clearance from systemic circulation upon repeated injection, both in mice and in beagles, and the ratio for the different time intervals, which showed that the ABC index exhibited significant difference within 30 minutes following the second injection, was good enough to evaluate the magnitude of ABC. This ABC index indicated that the 10 mol% PEG SLNs with a suitable prolonged circulation time induced the most marked ABC phenomenon in this research. This study demonstrated that, like PEGylated nanocarriers such as liposomes and polymeric nanoparticles, PEGylated SLNs induced the ABC phenomenon upon repeated injection -the beagle was a valuable experimental animal for this research. Furthermore, the authors considered that a relatively extended circulation time of the initial dose may be the underlying major factor determining the induction of the ABC phenomenon.

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“…In addition, they found that DOX-encapsulated PEGylated liposomes did not induce the enhanced clearance of a second injected "empty" PEGylated liposome. Ishida et al also systemically investigated the accelerated clearance of subsequent PEGylated liposome administration [121][122][123] and demonstrated that PEGylated liposomes induced PEG-specific IgM that were responsible for the rapid elimination of second injected PEGylated liposomes [124,125]. Furthermore, the induction of anti-PEG-specific IgM that recognized DOX-encapsulated PEGylated liposomes was significantly lower than that for "empty"…”

Section: Dams Et Al Reported That Repeated Injections Of Pegylated Lmentioning

confidence: 99%

Glycosylation-mediated targeting of carriers

Kawakami

Hashida

2014

Journal of Controlled Release

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For safe and effective therapy, drugs should be delivered selectively to their target tissues or cells at an optimal rate. Drug delivery system technology maximizes the therapeutic efficacy and minimizes unfavorable drug actions by controlling their distribution profiles. Ligand-receptor binding is a typical example of specific recognition mechanisms in the body; therefore, ligand-modified drug carriers have been developed for active targeting based on receptor-mediated endocytosis. Among the various ligands reported thus far, sugar recognition is a promising approach for active targeting because of their high affinity and expression. Glycosylation has been applied for both macromolecular and liposomal carriers for cell-selective drug targeting.Recently, the combination of ultrasound exposure and glycosylated bubble liposomes has been developed. In this review, recent advances of glycosylation-mediated targeted drug delivery systems are discussed.

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Effect of the physicochemical properties of initially injected liposomes on the clearance of subsequently injected PEGylated liposomes in mice

Cited by 109 publications

References 36 publications

Influence of phospholipid types and animal models on the accelerated blood clearance phenomenon of PEGylated liposomes upon repeated injection

Influence of phospholipid types and animal models on the accelerated blood clearance phenomenon of PEGylated liposomes upon repeated injection

Repeated injection of PEGylated solid lipid nanoparticles induces accelerated blood clearance in mice and beagles

Glycosylation-mediated targeting of carriers

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